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CXCR3 blocking peptide

Scan QR to view Datasheet Catalog #    MBS9217458 CXCR3 blocking peptide
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CXCR3, Blocking Peptide

★Popular Item★
 Also Known As   

CXCR3 Antibody (Center) Blocking peptide

 Product Synonym Names    C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; CKR-L2; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor; IP-10 receptor; CD183; CXCR3; GPR9
 Product Gene Name   

CXCR3 blocking peptide

[Similar Products]
 Product Synonym Gene Name    GPR9 [Similar Products]
 Antibody/Peptide Pairs    CXCR3 peptide (MBS9217458) is used for blocking the activity of CXCR3 antibody (MBS9210391)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    300574
 3D Structure    ModBase 3D Structure for P49682
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 Form/Format    Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
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 Cellular Location    Isoform 1: Cell membrane; Multi-pass membrane protein
 Clone Names    90921058
 Function    Isoform 1: Receptor for the C-X-C chem okine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogen icactivity of human mesangial cells (HMC) through a heterotrimeric G-protein signali ngpathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. Isoform 3: Mediates the activity of CXCL11
 Cellular Location    Isoform 1: Cell membrane; Multi-pass membrane protein
 Tissue Location    Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level)
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of CXCR3 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for CXCR3 blocking peptide

   This gene encodes a G protein-coupled receptor withselectivity for three chemokines, termed IP10(interferon-g-inducible 10 kDa protein), Mig (monokine induced byinterferon-g) and I-TAC (interferon-inducible T cella-chemoattractant). IP10, Mig and I-TAC belong to the structuralsubfamily of CXC chemokines, in which a single amino acid residueseparates the first two of four highly conserved Cys residues.Binding of chemokines to this protein induces cellular responsesthat are involved in leukocyte traffic, most notably integrinactivation, cytoskeletal changes and chemotactic migration.Inhibition by Bordetella pertussis toxin suggests thatheterotrimeric G protein of the Gi-subclass couple to this protein.Signal transduction has not been further analyzed but may includethe same enzymes that were identified in the signaling cascadeinduced by other chemokine receptors. As a consequence ofchemokine-induced cellular desensitization(phosphorylation-dependent receptor internalization), cellularresponses are typically rapid and short in duration. Cellularresponsiveness is restored after dephosphorylation of intracellularreceptors and subsequent recycling to the cell surface. This geneis prominently expressed in in vitro cultured effector/memory Tcells, and in T cells present in many types of inflamed tissues. Inaddition, IP10, Mig and I-TAC are commonly produced by local cellsin inflammatory lesion, suggesting th at this gene and itschemokines participate in the recruitment of inflammatory cells.Therefore, this protein is a target for the development of smallmolecular weight antagonists, which may be used in the treatment ofdiverse inflammatory diseases. Multiple transcript variantsencoding different isoforms have been found for this gene
NCBI/Uniprot data below describe general gene information for CXCR3. It may not necessarily be applicable to this product.
 NCBI GI #    4504099
 NCBI GeneID    2833
 NCBI Accession #    NP_001495.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001504.1 [Other Products]
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 UniProt Primary Accession #    P49682 [Other Products]
 UniProt Secondary Accession #    O15185; Q7Z710; Q9P2T4; Q9P2T5; B2R982 [Other Products]
 UniProt Related Accession #    P49682 [Other Products]
 Molecular Weight    28,715 Da
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 NCBI Official Full Name    C-X-C chemokine receptor type 3 isoform 1
 NCBI Official Synonym Full Names    C-X-C motif chemokine receptor 3
 NCBI Official Symbol    CXCR3 [Similar Products]
 NCBI Official Synonym Symbols   
GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R
[Similar Products]
 NCBI Protein Information    C-X-C chemokine receptor type 3
 UniProt Protein Name    C-X-C chemokine receptor type 3
 UniProt Synonym Protein Names   
CKR-L2; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor; IP-10 receptor; CD_antigen: CD183
 Protein Family    C-X-C chemokine receptor
 UniProt Gene Name    CXCR3 [Similar Products]
 UniProt Synonym Gene Names    GPR9; CXC-R3; CXCR-3; IP-10 receptor [Similar Products]
 UniProt Entry Name    CXCR3_HUMAN
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 NCBI Summary for CXCR3    This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
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 UniProt Comments for CXCR3    CXCR3: Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC). Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: Xq13

Cellular Component: cytoplasm; integral to plasma membrane; plasma membrane

Molecular Function: chemokine binding; chemokine receptor activity

Biological Process: cell adhesion; cell motility; cell surface receptor linked signal transduction; chemotaxis
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 Research Articles on CXCR3    1. congruent with the concept that inflammation plays a key role in the pathogenesis of LV dysfunction, MIG, IP10 and I-TAC add diagnostic accuracy over and beyond NT-pro BNP.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CXCR3 blocking peptidePathways associated with CXCR3 blocking peptide
 Reference Product  PubMed Publications
 CXCL10 blocking peptide  >962 publications with CXCR3 and CXCL10
 CXCL9 blocking peptide  >545 publications with CXCR3 and CXCL9
 CXCL11 blocking peptide  >356 publications with CXCR3 and CXCL11
 CCL5 blocking peptide  >169 publications with CXCR3 and CCL5
 CXCL12 blocking peptide  >140 publications with CXCR3 and CXCL12
 CCL21 blocking peptide  >54 publications with CXCR3 and CCL21
 CXCL13 blocking peptide  >32 publications with CXCR3 and CXCL13
 CCL19 blocking peptide  >30 publications with CXCR3 and CCL19
 CCL11 blocking peptide  >27 publications with CXCR3 and CCL11
 PF4 blocking peptide  >14 publications with CXCR3 and PF4
 Products by Pathway  Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
Diseases associated with CXCR3 blocking peptideOrgans/Tissues associated with CXCR3 blocking peptide
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >662 publications with CXCR3 and Inflammation
 Autoimmune Diseases Antibodies  >350 publications with CXCR3 and Autoimmune Diseases
 Necrosis Antibodies  >227 publications with CXCR3 and Necrosis
 Lung Diseases Antibodies  >200 publications with CXCR3 and Lung Diseases
 Hypersensitivity Antibodies  >146 publications with CXCR3 and Hypersensitivity
 Liver Diseases Antibodies  >140 publications with CXCR3 and Liver Diseases
 Carcinoma Antibodies  >122 publications with CXCR3 and Carcinoma
 Cardiovascular Diseases Antibodies  >111 publications with CXCR3 and Cardiovascular Diseases
 Death Antibodies  >92 publications with CXCR3 and Death
 Fibrosis Antibodies  >91 publications with CXCR3 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1667 publications with CXCR3 and Blood
 Brain Antibodies  >155 publications with CXCR3 and Brain
 Spleen Antibodies  >133 publications with CXCR3 and Spleen
 Intestine Antibodies  >78 publications with CXCR3 and Intestine
 Muscle Antibodies  >68 publications with CXCR3 and Muscle
 Connective Tissue Antibodies  >18 publications with CXCR3 and Connective Tissue
 Uncharacterized Tissue Antibodies  >2 publications with CXCR3 and Uncharacterized Tissue
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