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CASP7 blocking peptide :: Caspase-7 Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS151986 CASP7 blocking peptide
Unit / Price
0.05 mg  /  $135 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Caspase-7 (CASP7), Blocking Peptide

 Also Known As   

Caspase-7 Peptide

 Product Synonym Names    MCH3; CMH-1; LICE2; CASP-7; ICE-LAP3; MCH3; Caspase-7; Apoptotic protease Mch-3; caspase 7, apoptosis-related cysteine peptidase
 Product Gene Name   

CASP7 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    Caspase-7 peptide (MBS151986) is used for blocking the activity of Caspase-7 antibody (MBS151144)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Western Blot Protocol    Western Blot Peptide Blocking Protocol
 OMIM    601761
 3D Structure    ModBase 3D Structure for P55210
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 Form/Format    Liquid
 Concentration    200 ug/mL (lot specific)
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 Species    Human
 Buffer    PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
 Location    16 amino acids near the amino terminus of human caspase-7.
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 Preparation and Storage    Store Caspase-7 peptide at -20 degree C, stable for one year.
 Other Notes    Small volumes of CASP7 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for CASP7 blocking peptide   

Blocking (BL)

 Application Notes for CASP7 blocking peptide    Caspase-7 peptide is used for blocking the activity of caspase-7 antibody.
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NCBI/Uniprot data below describe general gene information for CASP7. It may not necessarily be applicable to this product.
 NCBI GI #    1730092
 NCBI GeneID    840
 NCBI Accession #    P55210.1 [Other Products]
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 UniProt Primary Accession #    P55210 [Other Products]
 UniProt Secondary Accession #    Q13364; Q53YD5; Q5SVL0; Q5SVL3; Q96BA0; B4DQU7; B5BU45; D3DRB8 [Other Products]
 UniProt Related Accession #    P55210 [Other Products]
 Molecular Weight    31,614 Da
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 NCBI Official Full Name    Caspase-7
 NCBI Official Synonym Full Names    caspase 7, apoptosis-related cysteine peptidase
 NCBI Official Symbol    CASP7 [Similar Products]
 NCBI Official Synonym Symbols   
MCH3; CMH-1; LICE2; CASP-7; ICE-LAP3
[Similar Products]
 NCBI Protein Information    caspase-7; apoptotic protease MCH-3; ICE-like apoptotic protease 3; caspase 7, apoptosis-related cysteine protease
 UniProt Protein Name    Caspase-7
 UniProt Synonym Protein Names   
Apoptotic protease Mch-3; CMH-1; ICE-like apoptotic protease 3; ICE-LAP3
 Protein Family    Caspase
 UniProt Gene Name    CASP7 [Similar Products]
 UniProt Synonym Gene Names    MCH3; CASP-7; ICE-LAP3 [Similar Products]
 UniProt Entry Name    CASP7_HUMAN
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 NCBI Summary for CASP7    This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
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 UniProt Comments for CASP7    CASP7: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly- 217' bond. Overexpression promotes programmed cell death. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain. Inhibited by isatin sulfonamides. Belongs to the peptidase C14A family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; Mitochondrial; Apoptosis; EC 3.4.22.60; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 10q25

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol

Molecular Function: protein binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity

Biological Process: apoptosis; caspase activation via cytochrome c; proteolysis; cell structure disassembly during apoptosis
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 Research Articles on CASP7    1. Phosphorylate caspase-7 bu Src at multiple tyrosine sites enhanced its cellular apoptotic effect.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CASP7 blocking peptidePathways associated with CASP7 blocking peptide
 Reference Product  PubMed Publications
 CASP9 blocking peptide  >387 publications with CASP7 and CASP9
 CASP8 blocking peptide  >276 publications with CASP7 and CASP8
 XIAP blocking peptide  >80 publications with CASP7 and XIAP
 BIRC5 blocking peptide  >45 publications with CASP7 and BIRC5
 PARP1 blocking peptide  >39 publications with CASP7 and PARP1
 APAF1 blocking peptide  >33 publications with CASP7 and APAF1
 GZMB blocking peptide  >20 publications with CASP7 and GZMB
 BIRC2 blocking peptide  >7 publications with CASP7 and BIRC2
 BIRC3 blocking peptide  >5 publications with CASP7 and BIRC3
 RB1 blocking peptide  >4 publications with CASP7 and RB1
 Products by Pathway  Pathway Diagram
 Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway antibodies  Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Apoptosis Modulation By HSP70 Pathway antibodies  Apoptosis Modulation By HSP70 Pathway Diagram
Diseases associated with CASP7 blocking peptideOrgans/Tissues associated with CASP7 blocking peptide
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >267 publications with CASP7 and Necrosis
 Breast Neoplasms Antibodies  >168 publications with CASP7 and Breast Neoplasms
 Inflammation Antibodies  >99 publications with CASP7 and Inflammation
 Nervous System Diseases Antibodies  >82 publications with CASP7 and Nervous System Diseases
 Prostatic Neoplasms Antibodies  >67 publications with CASP7 and Prostatic Neoplasms
 Neoplasms, Experimental Antibodies  >60 publications with CASP7 and Neoplasms, Experimental
 Liver Diseases Antibodies  >59 publications with CASP7 and Liver Diseases
 Cardiovascular Diseases Antibodies  >58 publications with CASP7 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >33 publications with CASP7 and Kidney Diseases
 Liver Neoplasms Antibodies  >33 publications with CASP7 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >182 publications with CASP7 and Blood
 Lung Antibodies  >119 publications with CASP7 and Lung
 Brain Antibodies  >115 publications with CASP7 and Brain
 Liver Antibodies  >113 publications with CASP7 and Liver
 Prostate Antibodies  >79 publications with CASP7 and Prostate
 Muscle Antibodies  >71 publications with CASP7 and Muscle
 Kidney Antibodies  >70 publications with CASP7 and Kidney
 Vascular Antibodies  >70 publications with CASP7 and Vascular
 Nerve Antibodies  >61 publications with CASP7 and Nerve
 Bone Antibodies  >55 publications with CASP7 and Bone
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