NP_003827
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,067 Da
NCBI Official Full Name
protein delta homolog 1
NCBI Official Synonym Full Names
delta-like 1 homolog (Drosophila)
NCBI Official Synonym Symbols
DLK; FA1; ZOG; pG2; DLK-1; PREF1; Delta1; Pref-1 [Similar Products]
NCBI Protein Information
protein delta homolog 1; secredeltin; fetal antigen 1; preadipocyte factor 1
UniProt Protein Name
Protein delta homolog 1
UniProt Synonym Protein Names
pG2Fetal antigen 1; FA1
UniProt Synonym Gene Names
UniProt Entry Name
DLK1_HUMAN
NCBI Summary for DLK1
This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass. [provided by RefSeq, Mar 2010]
UniProt Comments for DLK1
DLK1: May have a role in neuroendocrine differentiation. Monomer. Found within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult pancreas. Found also in some forms of neuroendocrine lung tumor tissue. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 14q32
Cellular Component: extracellular space; integral to membrane; external side of plasma membrane
Biological Process: Notch signaling pathway; regulation of gene expression; embryonic skeletal development; multicellular organismal development; negative regulation of Notch signaling pathway; cell differentiation; post-embryonic development
Research Articles on DLK1
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Products associated with DLK1 blocking peptide
Pathways associated with DLK1 blocking peptide
Diseases associated with DLK1 blocking peptide
Organs/Tissues associated with DLK1 blocking peptide
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