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PRKDC blocking peptide :: DNA-PKcs Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS8243983 PRKDC blocking peptide
Unit / Price
1 mg  /  $195 +1 FREE 8GB USB
5 mg  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DNA-PKcs (PRKDC), Blocking Peptide

 Also Known As   

DNA-PKcs (pT2647) Blocking Peptide

 Product Synonym Names    HYRC; HYRC1; DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; p460
 Product Gene Name   

PRKDC blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    DNA-PKcs peptide (MBS8243983) is used for blocking the activity of DNA-PKcs antibody (MBS8242701)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600899
 3D Structure    ModBase 3D Structure for P78527
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 Host    Synthetic
 Species Reactivity    Human, Monkey
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 Purity/Purification    >85%
 Form/Format    Lyophilized Powder
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 Quality Control    The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Other Notes    Small volumes of PRKDC blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PRKDC blocking peptide

   The peptide is used to block Anti-DNA-PKcs reactivity.
 Applications Tested/Suitable for PRKDC blocking peptide   

Blocking (BL)

 Application Notes for PRKDC blocking peptide    Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
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NCBI/Uniprot data below describe general gene information for PRKDC. It may not necessarily be applicable to this product.
 NCBI GI #    38258929
 NCBI GeneID    5591
 NCBI Accession #    P78527.3 [Other Products]
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 UniProt Primary Accession #    P78527 [Other Products]
 UniProt Secondary Accession #    P78528; Q13327; Q13337; Q14175; Q59H99; Q7Z611; Q96SE6; Q9UME3 [Other Products]
 UniProt Related Accession #    P78527 [Other Products]
 Molecular Weight    465,501 Da
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 NCBI Official Full Name    DNA-dependent protein kinase catalytic subunit
 NCBI Official Synonym Full Names    protein kinase, DNA-activated, catalytic polypeptide
 NCBI Official Symbol    PRKDC [Similar Products]
 NCBI Official Synonym Symbols   
HYRC; p350; DNAPK; DNPK1; HYRC1; IMD26; XRCC7; DNA-PKcs
[Similar Products]
 NCBI Protein Information    DNA-dependent protein kinase catalytic subunit
 UniProt Protein Name    DNA-dependent protein kinase catalytic subunit
 UniProt Synonym Protein Names   
DNPK1; p460
 UniProt Gene Name    PRKDC [Similar Products]
 UniProt Synonym Gene Names    HYRC; HYRC1; DNA-PK catalytic subunit; DNA-PKcs [Similar Products]
 UniProt Entry Name    PRKDC_HUMAN
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 NCBI Summary for PRKDC    This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]
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 UniProt Comments for PRKDC    DNAPK: an atypical protein kinase of the PIKK family. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. and modulation of transcription. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Defects cause severe combined immune deficiency (SCID) which is characterized by a lack of mature functional lymphocytes and a high susceptibility to lethal opportunistic infections. Required for repair of radiation-induced dsDNA breaks. Loss of function in mice or horses leads to the SCID (severe combined immune deficiency) phenotype due to failure of immunoglobulin rearrangement. Target of mutation in mismatch repair-deficient colorectal cancer. Inhibitor: KU-7059. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, atypical; Nucleolus; Kinase, protein; DNA repair, damage; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); ATYPICAL group; PIKK family; DNAPK subfamily

Chromosomal Location of Human Ortholog: 8q11

Cellular Component: cytosol; DNA-dependent protein kinase complex; membrane; nuclear chromosome, telomeric region; nucleolus; nucleoplasm; transcription factor complex

Molecular Function: ATP binding; DNA-dependent protein kinase activity; double-stranded DNA binding; enzyme binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transcription factor binding

Biological Process: B cell lineage commitment; brain development; cell proliferation; cellular response to insulin stimulus; DNA damage response, signal transduction resulting in induction of apoptosis; DNA repair; double-strand break repair; double-strand break repair via nonhomologous end joining; germ cell programmed cell death; heart development; immunoglobulin V(D)J recombination; innate immune response; negative regulation of apoptosis; negative regulation of immunoglobulin production; negative regulation of protein amino acid phosphorylation; peptidyl-serine phosphorylation; positive regulation of apoptosis; positive regulation of developmental growth; positive regulation of fibroblast proliferation; positive regulation of immune system process; positive regulation of interferon type I production; positive regulation of transcription from RNA polymerase II promoter; pro-B cell differentiation; protein destabilization; protein modification process; regulation of circadian rhythm; regulation of smooth muscle cell proliferation; response to activity; response to gamma radiation; rhythmic process; somitogenesis; spleen development; T cell differentiation in the thymus; T cell lineage commitment; T cell receptor V(D)J recombination; telomere capping; thymus development

Disease: Immunodeficiency 26 With Or Without Neurologic Abnormalities
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 Research Articles on PRKDC    1. Kaposi's sarcoma-associated herpesvirus appears then to selectively activate DNA damage response pathways via the ATM and DNA-PK DNA damage response kinases.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PRKDC blocking peptidePathways associated with PRKDC blocking peptide
 Reference Product  PubMed Publications
 XRCC6 blocking peptide  >221 publications with PRKDC and XRCC6
 XRCC5 blocking peptide  >174 publications with PRKDC and XRCC5
 XRCC4 blocking peptide  >68 publications with PRKDC and XRCC4
 LIG4 blocking peptide  >28 publications with PRKDC and LIG4
 H2AFX blocking peptide  >27 publications with PRKDC and H2AFX
 DCLRE1C blocking peptide  >21 publications with PRKDC and DCLRE1C
 TP53 blocking peptide  >18 publications with PRKDC and TP53
 AKT1 blocking peptide  >6 publications with PRKDC and AKT1
 RPA2 blocking peptide  >3 publications with PRKDC and RPA2
 UBC blocking peptide  >2 publications with PRKDC and UBC
 Products by Pathway  Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Class I PI3K Signaling Events Mediated By Akt Pathway antibodies  Class I PI3K Signaling Events Mediated By Akt Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 DNA Double-Strand Break Repair Pathway antibodies  DNA Double-Strand Break Repair Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 DNA-PK Complex Pathway antibodies  DNA-PK Complex Pathway Diagram
Diseases associated with PRKDC blocking peptideOrgans/Tissues associated with PRKDC blocking peptide
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >65 publications with PRKDC and Disease Models, Animal
 Nervous System Diseases Antibodies  >53 publications with PRKDC and Nervous System Diseases
 Chromosome Aberrations Antibodies  >51 publications with PRKDC and Chromosome Aberrations
 Breast Neoplasms Antibodies  >41 publications with PRKDC and Breast Neoplasms
 Adenocarcinoma Antibodies  >33 publications with PRKDC and Adenocarcinoma
 Lung Diseases Antibodies  >29 publications with PRKDC and Lung Diseases
 Lung Neoplasms Antibodies  >28 publications with PRKDC and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >27 publications with PRKDC and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >22 publications with PRKDC and Cell Transformation, Neoplastic
 Prostatic Neoplasms Antibodies  >18 publications with PRKDC and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >143 publications with PRKDC and Blood
 Brain Antibodies  >45 publications with PRKDC and Brain
 Bone Antibodies  >44 publications with PRKDC and Bone
 Lung Antibodies  >41 publications with PRKDC and Lung
 Liver Antibodies  >39 publications with PRKDC and Liver
 Bone Marrow Antibodies  >37 publications with PRKDC and Bone Marrow
 Spleen Antibodies  >29 publications with PRKDC and Spleen
 Skin Antibodies  >24 publications with PRKDC and Skin
 Prostate Antibodies  >19 publications with PRKDC and Prostate
 Kidney Antibodies  >17 publications with PRKDC and Kidney
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