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EPHB3 blocking peptide

Scan QR to view Datasheet Catalog #    MBS822644 EPHB3 blocking peptide
Unit / Price
1 mg  /  $160 +1 FREE 8GB USB
5 mg  /  $305 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EPHB3, Blocking Peptide

★Popular Item★
 Also Known As   

EPHB3 Blocking Peptide

 Product Synonym Names    ETK2; HEK2; TYRO6; Ephrin type-B receptor 3; EPH-like tyrosine kinase 2; EPH-like kinase 2; Embryonic kinase 2; EK2; hEK2; Tyrosine-protein kinase TYRO6
 Product Gene Name   

EPHB3 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    EPHB3 peptide (MBS822644) is used for blocking the activity of EPHB3 antibody (MBS820428)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601839
 3D Structure    ModBase 3D Structure for P54753
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 Species Reactivity    Human, Mouse, Rat, Chicken, Pig
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 Purity/Purification    >85%
 Form/Format    Lyophilized powder
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 Source    Synthetic
 Quality Control    The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Other Notes    Small volumes of EPHB3 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for EPHB3 blocking peptide

   The peptide is used to block Anti-EPHB3 Antibody reactivity.
 Applications Tested/Suitable for EPHB3 blocking peptide   

Blocking (BL)

 Application Notes for EPHB3 blocking peptide    Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
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NCBI/Uniprot data below describe general gene information for EPHB3. It may not necessarily be applicable to this product.
 NCBI GI #    17975768
 NCBI GeneID    2049
 NCBI Accession #    NP_004434.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004443.3 [Other Products]
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 UniProt Primary Accession #    P54753 [Other Products]
 UniProt Secondary Accession #    Q7Z740 [Other Products]
 UniProt Related Accession #    P54753 [Other Products]
 Molecular Weight    110,330 Da
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 NCBI Official Full Name    ephrin type-B receptor 3
 NCBI Official Synonym Full Names    EPH receptor B3
 NCBI Official Symbol    EPHB3 [Similar Products]
 NCBI Official Synonym Symbols   
ETK2; HEK2; TYRO6
[Similar Products]
 NCBI Protein Information    ephrin type-B receptor 3; EK2; EPH-like kinase 2; embryonic kinase 2; human embryo kinase 2; EPH-like tyrosine kinase 2; EPH-like tyrosine kinase-2; tyrosine-protein kinase TYRO6
 UniProt Protein Name    Ephrin type-B receptor 3
 UniProt Synonym Protein Names   
EPH-like tyrosine kinase 2; EPH-like kinase 2; Embryonic kinase 2; EK2; hEK2; Tyrosine-protein kinase TYRO6
 Protein Family    Ephrin type-B receptor
 UniProt Gene Name    EPHB3 [Similar Products]
 UniProt Synonym Gene Names    ETK2; HEK2; TYRO6; EPH-like kinase 2; EK2; hEK2 [Similar Products]
 UniProt Entry Name    EPHB3_HUMAN
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 NCBI Summary for EPHB3    Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010]
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 UniProt Comments for EPHB3    EphB3: a ubiquitous receptor tyrosine kinase of the Eph family. A receptor for ephrin-B family members: ephrin-B1 and -B2. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels.EphB3 contains 1 sterile alpha motif (SAM) domain and 2 fibronectin type III domains.

Protein type: Protein kinase, tyrosine (receptor); Membrane protein, integral; EC 2.7.10.1; Kinase, protein; Protein kinase, TK; TK group; Eph family

Chromosomal Location of Human Ortholog: 3q27.1

Cellular Component: integral to plasma membrane; dendrite; plasma membrane; extracellular region; cytosol

Molecular Function: ephrin receptor activity; axon guidance receptor activity; ATP binding

Biological Process: axon guidance; cell migration; peptidyl-tyrosine phosphorylation; thymus development; protein amino acid autophosphorylation; axonal fasciculation; central nervous system projection neuron axonogenesis; digestive tract morphogenesis; palate development; regulation of axonogenesis; corpus callosum development; positive regulation of synaptogenesis; regulation of cell-cell adhesion; ephrin receptor signaling pathway; angiogenesis; urogenital system development; retinal ganglion cell axon guidance
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 Research Articles on EPHB3    1. These results uncover enhancer decommissioning as a mechanism for transcriptional silencing of the EPHB3 tumor suppressor.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with EPHB3 blocking peptidePathways associated with EPHB3 blocking peptide
 Reference Product  PubMed Publications
 EFNB3 blocking peptide  >30 publications with EPHB3 and EFNB3
 RAC1 blocking peptide  >3 publications with EPHB3 and RAC1
 EFNB1 blocking peptide  >3 publications with EPHB3 and EFNB1
 CDC42 blocking peptide  >2 publications with EPHB3 and CDC42
 MLLT4 blocking peptide  >2 publications with EPHB3 and MLLT4
 CRK blocking peptide  >1 publications with EPHB3 and CRK
 EFNB2 blocking peptide  >1 publications with EPHB3 and EFNB2
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EPH-Ephrin Signaling Pathway antibodies  EPH-Ephrin Signaling Pathway Diagram
 EPH-ephrin Mediated Repulsion Of Cells Pathway antibodies  EPH-ephrin Mediated Repulsion Of Cells Pathway Diagram
 EPHB Forward Signaling Pathway antibodies  EPHB Forward Signaling Pathway Diagram
 EPHB-mediated Forward Signaling Pathway antibodies  EPHB-mediated Forward Signaling Pathway Diagram
 Ephrin Signaling Pathway antibodies  Ephrin Signaling Pathway Diagram
 EphrinB-EPHB Pathway antibodies  EphrinB-EPHB Pathway Diagram
Diseases associated with EPHB3 blocking peptideOrgans/Tissues associated with EPHB3 blocking peptide
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >12 publications with EPHB3 and Nervous System Diseases
 Congenital Abnormalities Antibodies  >9 publications with EPHB3 and Congenital Abnormalities
 Disease Models, Animal Antibodies  >7 publications with EPHB3 and Disease Models, Animal
 Brain Diseases Antibodies  >6 publications with EPHB3 and Brain Diseases
 Cleft Palate Antibodies  >5 publications with EPHB3 and Cleft Palate
 Lung Diseases Antibodies  >5 publications with EPHB3 and Lung Diseases
 Cell Transformation, Neoplastic Antibodies  >4 publications with EPHB3 and Cell Transformation, Neoplastic
 Inflammation Antibodies  >4 publications with EPHB3 and Inflammation
 Fibrosis Antibodies  >3 publications with EPHB3 and Fibrosis
 Nervous System Malformations Antibodies  >2 publications with EPHB3 and Nervous System Malformations
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >33 publications with EPHB3 and Brain
 Intestine Antibodies  >18 publications with EPHB3 and Intestine
 Embryonic Tissue Antibodies  >16 publications with EPHB3 and Embryonic Tissue
 Eye Antibodies  >10 publications with EPHB3 and Eye
 Lung Antibodies  >8 publications with EPHB3 and Lung
 Prostate Antibodies  >6 publications with EPHB3 and Prostate
 Bone Antibodies  >6 publications with EPHB3 and Bone
 Pancreas Antibodies  >4 publications with EPHB3 and Pancreas
 Stomach Antibodies  >4 publications with EPHB3 and Stomach
 Mouth Antibodies  >3 publications with EPHB3 and Mouth
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