NP_001267724.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,498 Da
NCBI Official Full Name
ephrin type-B receptor 6 isoform b
NCBI Official Synonym Full Names
EPH receptor B6
NCBI Official Synonym Symbols
NCBI Protein Information
ephrin type-B receptor 6; tyrosine-protein kinase-defective receptor EPH-6; human kinase-defective Eph-family receptor protein
UniProt Protein Name
Ephrin type-B receptor 6
UniProt Synonym Protein Names
HEP; Tyrosine-protein kinase-defective receptor EPH-6
UniProt Entry Name
EPHB6_HUMAN
NCBI Summary for EPHB6
This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Comments for EPHB6
EphB6: Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; EC 2.7.10.1; Protein kinase, TK; Kinase, protein; Protein kinase, tyrosine (receptor); TK group; Eph family
Chromosomal Location of Human Ortholog: 7q33-q35
Cellular Component: integral to plasma membrane; plasma membrane; extracellular region; cytosol
Molecular Function: ephrin receptor activity; receptor activity; ATP binding
Biological Process: axon guidance; ephrin receptor signaling pathway; protein amino acid phosphorylation
Research Articles on EPHB6
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Products associated with EPHB6 blocking peptide
Pathways associated with EPHB6 blocking peptide
Diseases associated with EPHB6 blocking peptide
Organs/Tissues associated with EPHB6 blocking peptide
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