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ERAP1 blocking peptide

Scan QR to view Datasheet Catalog #    MBS822829 ERAP1 blocking peptide
Unit / Price
1 mg  /  $160 +1 FREE 8GB USB
5 mg  /  $305 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ERAP1, Blocking Peptide

 Also Known As   

ERAP1 Blocking Peptide

 Product Synonym Names    APPILS; ARTS1; KIAA0525; Endoplasmic reticulum aminopeptidase 1; ARTS-1; Adipocyte-derived leucine aminopeptidase; A-LAP; Aminopeptidase PILS; Puromycin-insensitive leucyl-specific aminopeptidase; PILS-AP; Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
 Product Gene Name   

ERAP1 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    ERAP1 peptide (MBS822829) is used for blocking the activity of ERAP1 antibody (MBS821467)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606832
 3D Structure    ModBase 3D Structure for Q9NZ08
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 Host    Synthetic
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    >85%
 Form/Format    Lyophilized powder
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 Quality Control    The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Other Notes    Small volumes of ERAP1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for ERAP1 blocking peptide

   The peptide is used to block Anti-ERAP1 Antibody reactivity.
 Applications Tested/Suitable for ERAP1 blocking peptide   

Blocking (BL)

 Application Notes for ERAP1 blocking peptide    Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
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NCBI/Uniprot data below describe general gene information for ERAP1. It may not necessarily be applicable to this product.
 NCBI GI #    94818891
 NCBI GeneID    51752
 NCBI Accession #    NP_001035548.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001040458.1 [Other Products]
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 UniProt Primary Accession #    Q9NZ08 [Other Products]
 UniProt Secondary Accession #    O60278; Q6UWY6; Q8NEL4; Q8TAD0; Q9UHF8; Q9UKY2 [Other Products]
 UniProt Related Accession #    Q9NZ08 [Other Products]
 Molecular Weight    107,841 Da
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 NCBI Official Full Name    endoplasmic reticulum aminopeptidase 1 isoform b
 NCBI Official Synonym Full Names    endoplasmic reticulum aminopeptidase 1
 NCBI Official Symbol    ERAP1 [Similar Products]
 NCBI Official Synonym Symbols   
ALAP; A-LAP; ARTS1; ERAAP; APPILS; ARTS-1; ERAAP1; PILSAP; PILS-AP
[Similar Products]
 NCBI Protein Information    endoplasmic reticulum aminopeptidase 1; aminopeptidase PILS; adipocyte-derived leucine aminopeptidase; aminopeptidase regulator of TNFR1 shedding; puromycin-insensitive leucyl-specific aminopeptidase; endoplasmic reticulum aminopeptidase 1 delta-Exon-11 isoform; endoplasmic reticulum aminopeptidase 1 delta-Exon-13 isoform; endoplasmic reticulum aminopeptidase 1 delta-Exon-14 isoform; endoplasmic reticulum aminopeptidase 1 delta-Exon-15 isoform; endoplasmic reticulum aminopeptidase associated with antigen processing; type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
 UniProt Protein Name    Endoplasmic reticulum aminopeptidase 1
 UniProt Synonym Protein Names   
ARTS-1; Adipocyte-derived leucine aminopeptidase; A-LAP; Aminopeptidase PILS; Puromycin-insensitive leucyl-specific aminopeptidase; PILS-AP; Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
 Protein Family    Endoplasmic reticulum aminopeptidase
 UniProt Gene Name    ERAP1 [Similar Products]
 UniProt Synonym Gene Names    APPILS; ARTS1; KIAA0525; A-LAP; PILS-AP [Similar Products]
 UniProt Entry Name    ERAP1_HUMAN
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 NCBI Summary for ERAP1    The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
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 UniProt Comments for ERAP1    ARTS1: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. Belongs to the peptidase M1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.11.-; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 5q15

Cellular Component: extracellular space; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; endoplasmic reticulum lumen; extracellular region; integral to membrane; cytosol

Molecular Function: protein binding; interleukin-6 receptor binding; metalloexopeptidase activity; interleukin-1, Type II receptor binding; zinc ion binding; aminopeptidase activity

Biological Process: fat cell differentiation; antigen processing and presentation of peptide antigen via MHC class I; positive regulation of angiogenesis; response to bacterium; regulation of blood pressure; membrane protein ectodomain proteolysis; angiogenesis; antigen processing and presentation of endogenous peptide antigen via MHC class I; regulation of innate immune response
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 Research Articles on ERAP1    1. Data indicate that dimerization of endoplasmic reticulum aminopeptidases ERAP1/2 creates complexes with superior peptide-trimming efficacy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ERAP1 blocking peptidePathways associated with ERAP1 blocking peptide
 Reference Product  PubMed Publications
 HLA-B blocking peptide  >45 publications with ERAP1 and HLA-B
 HLA-A blocking peptide  >7 publications with ERAP1 and HLA-A
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies  Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with ERAP1 blocking peptideOrgans/Tissues associated with ERAP1 blocking peptide
 Disease Name  Pubmed Publications
 Spondylitis, Ankylosing Antibodies  >74 publications with ERAP1 and Spondylitis, Ankylosing
 Musculoskeletal Diseases Antibodies  >63 publications with ERAP1 and Musculoskeletal Diseases
 Psoriasis Antibodies  >32 publications with ERAP1 and Psoriasis
 Immune System Diseases Antibodies  >17 publications with ERAP1 and Immune System Diseases
 Necrosis Antibodies  >16 publications with ERAP1 and Necrosis
 Inflammation Antibodies  >6 publications with ERAP1 and Inflammation
 Uterine Cervical Neoplasms Antibodies  >5 publications with ERAP1 and Uterine Cervical Neoplasms
 Nervous System Diseases Antibodies  >4 publications with ERAP1 and Nervous System Diseases
 Behcet Syndrome Antibodies  >3 publications with ERAP1 and Behcet Syndrome
 Liver Diseases Antibodies  >2 publications with ERAP1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >37 publications with ERAP1 and Blood
 Skin Antibodies  >7 publications with ERAP1 and Skin
 Vascular Antibodies  >6 publications with ERAP1 and Vascular
 Bone Antibodies  >5 publications with ERAP1 and Bone
 Placenta Antibodies  >5 publications with ERAP1 and Placenta
 Lung Antibodies  >4 publications with ERAP1 and Lung
 Lymph Node Antibodies  >3 publications with ERAP1 and Lymph Node
 Liver Antibodies  >3 publications with ERAP1 and Liver
 Heart Antibodies  >3 publications with ERAP1 and Heart
 Uterus Antibodies  >2 publications with ERAP1 and Uterus
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