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FBXL2 (HGNC:13598) blocking peptide :: FBXL2 Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS9225481 FBXL2 (HGNC:13598) blocking peptide
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FBXL2 (FBXL2 (HGNC:13598)), Blocking Peptide

 Also Known As   

FBXL2 Antibody (C-term) Blocking Peptide

 Product Synonym Names    F-box/LRR-repeat protein 2; F-box and leucine-rich repeat protein 2 ; F-box protein FBL2/FBL3; FBXL2
 Product Gene Name   

FBXL2 (HGNC:13598) blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    FBXL2 peptide (MBS9225481) is used for blocking the activity of FBXL2 antibody (MBS9212225)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605652
 3D Structure    ModBase 3D Structure for Q9UKC9
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 Form/Format    Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
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 Cellular Location    Membrane; Lipid-anchor
 Tissue Location    Expressed in brain, heart, kidney, liver, lung, pancreas and placenta.
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of FBXL2 (HGNC:13598) blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for FBXL2 (HGNC:13598) blocking peptide

   Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation may induce cell-cycle arrest in G(0). SCF(FBXL2) may also mediate PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and indirectly autophagy (PubMed:22323446, PubMed:22020328, PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation may regulate synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity).
NCBI/Uniprot data below describe general gene information for FBXL2 (HGNC:13598). It may not necessarily be applicable to this product.
 NCBI GI #    145559475
 NCBI GeneID    25827
 NCBI Accession #    Q9UKC9.3 [Other Products]
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 UniProt Primary Accession #    Q9UKC9 [Other Products]
 UniProt Secondary Accession #    Q6IAN3; Q9NVQ8; Q9UK27; Q9UKA5; Q9Y3Y9; B4DQV0; E9PD06 [Other Products]
 UniProt Related Accession #    Q9UKC9 [Other Products]
 Molecular Weight    39,613 Da
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 NCBI Official Full Name    F-box/LRR-repeat protein 2
 NCBI Official Synonym Full Names    F-box and leucine rich repeat protein 2
 NCBI Official Symbol    FBXL2 [Similar Products]
 NCBI Official Synonym Symbols   
FBL2; FBL3
[Similar Products]
 NCBI Protein Information    F-box/LRR-repeat protein 2
 UniProt Protein Name    F-box/LRR-repeat protein 2
 UniProt Synonym Protein Names   
F-box and leucine-rich repeat protein 2
 UniProt Gene Name    FBXL2 [Similar Products]
 UniProt Entry Name    FBXL2_HUMAN
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 NCBI Summary for FBXL2 (HGNC:13598)    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
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 UniProt Comments for FBXL2 (HGNC:13598)    FBXL2: Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized by calmodulin. Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation, leading to cell-cycle arrest in G(0), also antagonized by calmodulin. Binds to hepatitis C virus non-structural protein 5A (NS5A) in a reaction crucial for hepatitis C virus RNA replication.

Protein type: Ubiquitin ligase

Chromosomal Location of Human Ortholog: 3p22.3

Cellular Component: cytoplasm; membrane; SCF ubiquitin ligase complex

Molecular Function: protein binding; protein phosphatase binding; ubiquitin-protein ligase activity

Biological Process: protein modification process; protein ubiquitination; proteolysis; regulation of autophagy; regulation of phosphoinositide 3-kinase cascade; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
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 Research Articles on FBXL2 (HGNC:13598)    1. FBXL2 recognizes Trp-73 within NALP3 for interaction and targets Lys-689 within NALP3 for ubiquitin ligation and degradation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with FBXL2 (HGNC:13598) blocking peptideOrgans/Tissues associated with FBXL2 (HGNC:13598) blocking peptide
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >4 publications with FBXL2 (HGNC:13598) and Inflammation
 Necrosis Antibodies  >4 publications with FBXL2 (HGNC:13598) and Necrosis
 Disease Models, Animal Antibodies  >1 publications with FBXL2 (HGNC:13598) and Disease Models, Animal
 Urogenital Abnormalities Antibodies  >1 publications with FBXL2 (HGNC:13598) and Urogenital Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >9 publications with FBXL2 (HGNC:13598) and Lung
 Nerve Antibodies  >2 publications with FBXL2 (HGNC:13598) and Nerve
 Liver Antibodies  >2 publications with FBXL2 (HGNC:13598) and Liver
 Intestine Antibodies  >1 publications with FBXL2 (HGNC:13598) and Intestine
 Brain Antibodies  >1 publications with FBXL2 (HGNC:13598) and Brain
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