AAH17247.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,445 Da
NCBI Official Full Name
FUBP1 protein
NCBI Official Synonym Full Names
far upstream element binding protein 1
NCBI Protein Information
far upstream element-binding protein 1
UniProt Protein Name
Syntaxin-10
UniProt Synonym Gene Names
UniProt Entry Name
STX10_HUMAN
NCBI Summary for FYN
The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
UniProt Comments for FYN
STX10: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. Belongs to the syntaxin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Vesicle
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: cytosol; integral to membrane; perinuclear region of cytoplasm; SNARE complex; trans-Golgi network; trans-Golgi network membrane; vesicle
Molecular Function: protein binding; SNAP receptor activity; syntaxin binding
Biological Process: intracellular protein transport; regulation of protein localization; retrograde transport, endosome to Golgi; vesicle docking; vesicle fusion
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Diseases associated with FYN blocking peptide
Organs/Tissues associated with FYN blocking peptide
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