CAB58363.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,991 Da
NCBI Official Full Name
GCN2 eIF2alpha kinase
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 2 alpha kinase 4
NCBI Protein Information
eIF-2-alpha kinase GCN2
UniProt Protein Name
eIF-2-alpha kinase GCN2
UniProt Synonym Protein Names
Eukaryotic translation initiation factor 2-alpha kinase 4
UniProt Synonym Gene Names
UniProt Entry Name
E2AK4_MOUSE
UniProt Comments for GCN2
GCN2: a kinase of the PEK family. Phosphorylates and inhibits eukaryotic initiation factor (eIF)-2 alpha, providing an important protective mechanism during various cellular stress conditions including endoplasmic reticulum (ER) stress.
Protein type: Protein kinase, Other; Translation; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Other group; PEK family; GCN2 subfamily
Cellular Component: cytoplasm; intracellular; polysome
Molecular Function: ATP binding; eukaryotic translation initiation factor 2alpha kinase activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; RNA binding; transferase activity; tRNA binding
Biological Process: adaptive immune response; cell cycle; cell cycle arrest; cell differentiation; cellular response to amino acid starvation; cellular response to starvation; defense response to virus; immune system process; inhibition of CREB transcription factor; learning; long-term memory; negative regulation of neuron differentiation; negative regulation of translation; negative regulation of translation initiation in response to stress; negative regulation of translational initiation; nervous system development; phosphorylation; positive regulation of adaptive immune response; positive regulation of defense response to virus by host; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of translation; regulation of translation initiation in response to stress; regulation of translational initiation; T cell activation during immune response; unfolded protein response; viral protein biosynthetic process; viral reproduction
Research Articles on GCN2
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Pathways associated with GCN2 blocking peptide
Diseases associated with GCN2 blocking peptide
Organs/Tissues associated with GCN2 blocking peptide
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