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GREM1 blocking peptide

Scan QR to view Datasheet Catalog #    MBS9218966 GREM1 blocking peptide
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GREM1, Blocking Peptide

★Popular Item★
 Also Known As   

GREM1 Antibody (C-term) Blocking peptide

 Product Synonym Names    Gremlin-1; Cell proliferation-inducing gene 2 protein; Cysteine knot superfamily 1; BMP antagonist 1; DAN domain family member 2; Down-regulated in Mos-transformed cells protein; Increased in high glucose protein 2; IHG-2; GREM1; CKTSF1B1; DAND2; DRM
 Product Gene Name   

GREM1 blocking peptide

[Similar Products]
 Product Synonym Gene Name    CKTSF1B1; DAND2; DRM [Similar Products]
 Antibody/Peptide Pairs    GREM1 peptide (MBS9218966) is used for blocking the activity of GREM1 antibody (MBS9208833)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601228
 3D Structure    ModBase 3D Structure for O60565
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 Clone Number    101008305
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 Form/Format    Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
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 Cellular Location    Secreted.
    
 Tissue Location    Highly expressed in small intestine, fetal brain and colon. Expression is restricted to intestinal subepithelial myofibroblasts (ISEMFs) at the crypt base. In subjects with HMPS1, by contrast, GREM1 is expressed, not only in basal ISEMFs, but also at very high levels in epithelial cells (predominantly colonocytes), with expression extending most of the way up the sides of the crypt. Weakly expressed in brain, ovary, prostate, pancreas and skeletal muscle. In brain found in the region localized around the internal capsule in the large subcortical nuclei, including caudate, putamen, substantia nigra, thalamus and subthalamus. Predominantly expressed in normal cells including neurons, astrocytes and fibroblasts
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of GREM1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for GREM1 blocking peptide

   Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis (By similarity).
NCBI/Uniprot data below describe general gene information for GREM1. It may not necessarily be applicable to this product.
 NCBI GI #    62510668
 NCBI GeneID    26585
 NCBI Accession #    O60565.1 [Other Products]
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 UniProt Primary Accession #    O60565 [Other Products]
 UniProt Secondary Accession #    Q52LV3; Q8N914; Q8N936 [Other Products]
 UniProt Related Accession #    O60565 [Other Products]
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 NCBI Official Full Name    Gremlin-1
 NCBI Official Synonym Full Names    gremlin 1, DAN family BMP antagonist
 NCBI Official Symbol    GREM1 [Similar Products]
 NCBI Official Synonym Symbols   
DRM; HMPS; MPSH; PIG2; CRAC1; CRCS4; DAND2; HMPS1; IHG-2; DUP15q; C15DUPq; GREMLIN; CKTSF1B1
[Similar Products]
 NCBI Protein Information    gremlin-1
 UniProt Protein Name    Gremlin-1
 UniProt Synonym Protein Names   
Cell proliferation-inducing gene 2 protein; Cysteine knot superfamily 1, BMP antagonist 1; DAN domain family member 2; Down-regulated in Mos-transformed cells protein; Increased in high glucose protein 2; IHG-2
 Protein Family    Gremlin
 UniProt Gene Name    GREM1 [Similar Products]
 UniProt Synonym Gene Names    CKTSF1B1; DAND2; DRM; IHG-2 [Similar Products]
 UniProt Entry Name    GREM1_HUMAN
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 NCBI Summary for GREM1    This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
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 UniProt Comments for GREM1    GREM1: Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis. Interacts with SLIT1 and SLIT2 in a glycosylation- dependent manner. By high glucose through TGFB1-mediated pathways in mesangial cell. Down-regulated in tumor cell lines. Highly expressed in small intestine, fetal brain and colon. Weakly expressed in brain, ovary, prostate, pancreas and skeletal muscle. In brain found in the region localized around the internal capsule in the large subcortical nuclei, including caudate, putamen, substantia nigra, thalamus and subthalamus. Predominantly expressed in normal cells including neurons, astrocytes and fibroblasts. Belongs to the DAN family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 15q13.3

Molecular Function: morphogen activity; protein binding; receptor agonist activity; transmembrane receptor protein tyrosine kinase activator activity; vascular endothelial growth factor receptor 2 binding

Biological Process: cell migration during sprouting angiogenesis; cell morphogenesis; collagen fibril organization; determination of dorsal identity; limb development; negative regulation of apoptosis; negative regulation of BMP signaling pathway; negative regulation of bone mineralization; negative regulation of bone remodeling; negative regulation of chondrocyte differentiation; negative regulation of osteoblast proliferation; positive regulation of cell proliferation; positive regulation of receptor internalization; positive regulation of telomerase activity; positive regulation of transcription from RNA polymerase II promoter; regulation of stress-activated MAPK cascade; signal transduction
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 Research Articles on GREM1    1. Data suggest that the hereditary mixed polyposis syndrome (HMPS) 40 kb duplication upstream of the gremlin 1 protein (GREM1) gene is present at low rates in Jewish Ashkenazi individuals of a familial predisposition to colorectal cancer (CRC).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GREM1 blocking peptidePathways associated with GREM1 blocking peptide
 Reference Product  PubMed Publications
 BMP4 blocking peptide  >45 publications with GREM1 and BMP4
 BMP2 blocking peptide  >22 publications with GREM1 and BMP2
 BMP7 blocking peptide  >13 publications with GREM1 and BMP7
 BMPR2 blocking peptide  >8 publications with GREM1 and BMPR2
 BMPR1A blocking peptide  >8 publications with GREM1 and BMPR1A
 FMN1 blocking peptide  >6 publications with GREM1 and FMN1
 BAMBI blocking peptide  >2 publications with GREM1 and BAMBI
 YWHAH blocking peptide  >1 publications with GREM1 and YWHAH
 BMPR1B blocking peptide  >1 publications with GREM1 and BMPR1B
 Products by Pathway  Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
Diseases associated with GREM1 blocking peptideOrgans/Tissues associated with GREM1 blocking peptide
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >30 publications with GREM1 and Fibrosis
 Kidney Diseases Antibodies  >28 publications with GREM1 and Kidney Diseases
 Carcinoma Antibodies  >25 publications with GREM1 and Carcinoma
 Congenital Abnormalities Antibodies  >24 publications with GREM1 and Congenital Abnormalities
 Colorectal Neoplasms Antibodies  >22 publications with GREM1 and Colorectal Neoplasms
 Disease Models, Animal Antibodies  >17 publications with GREM1 and Disease Models, Animal
 Inflammation Antibodies  >16 publications with GREM1 and Inflammation
 Hypertension Antibodies  >14 publications with GREM1 and Hypertension
 Adenocarcinoma Antibodies  >10 publications with GREM1 and Adenocarcinoma
 Lung Neoplasms Antibodies  >9 publications with GREM1 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >143 publications with GREM1 and Bone
 Kidney Antibodies  >46 publications with GREM1 and Kidney
 Lung Antibodies  >29 publications with GREM1 and Lung
 Embryonic Tissue Antibodies  >27 publications with GREM1 and Embryonic Tissue
 Vascular Antibodies  >22 publications with GREM1 and Vascular
 Muscle Antibodies  >21 publications with GREM1 and Muscle
 Connective Tissue Antibodies  >20 publications with GREM1 and Connective Tissue
 Brain Antibodies  >12 publications with GREM1 and Brain
 Skin Antibodies  >10 publications with GREM1 and Skin
 Intestine Antibodies  >8 publications with GREM1 and Intestine
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