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IKBKE blocking peptide :: IKK epsilon (IKKE) Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS9227571
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IKK epsilon (IKKE) (IKBKE), Blocking Peptide

 Also Known As   

IKK epsilon (IKKE) Antibody (C-term) Blocking peptide

 Product Synonym Names    Inhibitor of nuclear factor kappa-B kinase subunit epsilon; I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IkBKE; Inducible I kappa-B kinase; IKK-i; IKBKE; IKKE; IKKI; KIAA0151
 Product Gene Name   

IKBKE blocking peptide

[Similar Products]
 Product Synonym Gene Name    IKKE; IKKI; KIAA0151 [Similar Products]
 Antibody/Peptide Pairs    IKK epsilon (IKKE) peptide (MBS9227571) is used for blocking the activity of IKK epsilon (IKKE) antibody (MBS9212797)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605048
 3D Structure    ModBase 3D Structure for Q14164
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 Specificity    The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human IKKE. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
 Form/Format    The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
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 Cellular Location    Cytoplasm. Nucleus. Nucleus, PML body. Note: Targeting to PML nuclear bodies upon DNA damage is TOPORS- dependent
 Tissue Location    Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary and colon
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of IKBKE blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IKBKE blocking peptide

   Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG- I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1.
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NCBI/Uniprot data below describe general gene information for IKBKE. It may not necessarily be applicable to this product.
 NCBI GI #    14548079
 NCBI GeneID    9641
 NCBI Accession #    Q14164.1 [Other Products]
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 UniProt Primary Accession #    Q14164 [Other Products]
 UniProt Secondary Accession #    Q3B754; Q3KR43; Q5JTS6; D3DT78 [Other Products]
 UniProt Related Accession #    Q14164 [Other Products]
 Molecular Weight    70,816 Da
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 NCBI Official Full Name    Inhibitor of nuclear factor kappa-B kinase subunit epsilon
 NCBI Official Synonym Full Names    inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
 NCBI Official Symbol    IKBKE [Similar Products]
 NCBI Official Synonym Symbols   
IKKE; IKKI; IKK-E; IKK-i
[Similar Products]
 NCBI Protein Information    inhibitor of nuclear factor kappa-B kinase subunit epsilon
 UniProt Protein Name    Inhibitor of nuclear factor kappa-B kinase subunit epsilon
 UniProt Synonym Protein Names   
Inducible I kappa-B kinase; IKK-i
 Protein Family    Inhibitor of nuclear factor kappa-B kinase
 UniProt Gene Name    IKBKE [Similar Products]
 UniProt Synonym Gene Names    IKKE; IKKI; KIAA0151; I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IkBKE; IKK-i [Similar Products]
 UniProt Entry Name    IKKE_HUMAN
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IKBKE blocking peptidePathways associated with IKBKE blocking peptide
 Reference Product  PubMed Publications
 TNF blocking peptide  >308 publications with IKBKE and TNF
 NFKBIA blocking peptide  >178 publications with IKBKE and NFKBIA
 RELA blocking peptide  >122 publications with IKBKE and RELA
 IRF3 blocking peptide  >28 publications with IKBKE and IRF3
 TANK blocking peptide  >21 publications with IKBKE and TANK
 STAT3 blocking peptide  >10 publications with IKBKE and STAT3
 TICAM1 blocking peptide  >8 publications with IKBKE and TICAM1
 IFNB1 blocking peptide  >2 publications with IKBKE and IFNB1
 FOXO3 blocking peptide  >1 publications with IKBKE and FOXO3
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies  Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with IKBKE blocking peptideOrgans/Tissues associated with IKBKE blocking peptide
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >439 publications with IKBKE and Necrosis
 Inflammation Antibodies  >192 publications with IKBKE and Inflammation
 Breast Neoplasms Antibodies  >34 publications with IKBKE and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >29 publications with IKBKE and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >27 publications with IKBKE and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >25 publications with IKBKE and Cardiovascular Diseases
 Atherosclerosis Antibodies  >16 publications with IKBKE and Atherosclerosis
 Liver Diseases Antibodies  >14 publications with IKBKE and Liver Diseases
 Neoplasms, Experimental Antibodies  >13 publications with IKBKE and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >12 publications with IKBKE and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >181 publications with IKBKE and Blood
 Vascular Antibodies  >59 publications with IKBKE and Vascular
 Lung Antibodies  >57 publications with IKBKE and Lung
 Skin Antibodies  >46 publications with IKBKE and Skin
 Bone Antibodies  >33 publications with IKBKE and Bone
 Embryonic Tissue Antibodies  >33 publications with IKBKE and Embryonic Tissue
 Kidney Antibodies  >30 publications with IKBKE and Kidney
 Muscle Antibodies  >27 publications with IKBKE and Muscle
 Intestine Antibodies  >21 publications with IKBKE and Intestine
 Heart Antibodies  >21 publications with IKBKE and Heart
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