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IL27 blocking peptide :: IL-27 Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS152856 IL27 blocking peptide
Unit / Price
0.05 mg  /  $135 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL-27 (IL27), Blocking Peptide

 Also Known As   

IL-27 Peptide

 Product Synonym Names    p28; IL30; IL-27; IL27A; IL-27A; IL27p28; Interleukin-27 subunit alpha; p28; IL-27 subunit alpha; interleukin 27
 Product Gene Name   

IL27 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    IL-27 peptide (MBS152856) is used for blocking the activity of IL-27 antibody (MBS150576)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Western Blot Protocol    Western Blot Peptide Blocking Protocol
 OMIM    608273
 3D Structure    ModBase 3D Structure for Q8NEV9
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 Form/Format    Liquid
 Concentration    200 ug/mL (lot specific)
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 Species    Human
 Buffer    PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
 Location    14 amino acids near the center of human IL-27.
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 Preparation and Storage    Store IL-27 peptide at -20 degree C, stable for one year.
 Other Notes    Small volumes of IL27 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for IL27 blocking peptide   

Blocking (BL)

 Application Notes for IL27 blocking peptide    IL-27 peptide is used for blocking activity of IL-27 antibody.
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NCBI/Uniprot data below describe general gene information for IL27. It may not necessarily be applicable to this product.
 NCBI GI #    28416913
 NCBI GeneID    246778
 NCBI Accession #    NP_663634 [Other Products]
 NCBI GenBank Nucleotide #    NM_145659.3 [Other Products]
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 UniProt Primary Accession #    Q8NEV9 [Other Products]
 UniProt Secondary Accession #    Q6P676; A0N0L2 [Other Products]
 UniProt Related Accession #    Q8NEV9 [Other Products]
 Molecular Weight    27,493 Da
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 NCBI Official Full Name    interleukin-27 subunit alpha
 NCBI Official Synonym Full Names    interleukin 27
 NCBI Official Symbol    IL27 [Similar Products]
 NCBI Official Synonym Symbols   
p28; IL30; IL-27; IL27A; IL-27A; IL27p28
[Similar Products]
 NCBI Protein Information    interleukin-27 subunit alpha; IL27-A; IL-27-A; interleukin 30; interleukin-30; IL-27 p28 subunit; IL-27 subunit alpha
 UniProt Protein Name    Interleukin-27 subunit alpha
 UniProt Synonym Protein Names   
Interleukin-30; p28
 Protein Family    Interleukin
 UniProt Gene Name    IL27 [Similar Products]
 UniProt Synonym Gene Names    IL27A; IL30; IL-27 subunit alpha; IL-27-A; IL27-A [Similar Products]
 UniProt Entry Name    IL27A_HUMAN
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 NCBI Summary for IL27    The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008]
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 UniProt Comments for IL27    IL27-alpha: Cytokine with pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon- gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK- dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells development. In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL-27 subunit p28 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of proinflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27 has also an effect on cytokine production, it suppresses proinflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP- 10/CXCL10 and MIG/CXCL9. In vein endothelial cells, it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II. IL-27 also demonstrates antiviral activity with inhibitory properties on HIV-1 replivation. Belongs to the IL-6 superfamily.

Protein type: Secreted, signal peptide; Cytokine; Secreted

Chromosomal Location of Human Ortholog: 16p11

Cellular Component: extracellular space

Molecular Function: interleukin-27 receptor binding; cytokine activity; receptor binding

Biological Process: regulation of T-helper 1 cell differentiation; response to bacterium; regulation of T cell proliferation; regulation of defense response to virus; innate immune response; inflammatory response; positive regulation of interferon-gamma biosynthetic process
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 Research Articles on IL27    1. plasma IL-27 level was significantly upregulated in HIV-mono-infected and HIV/HCV-co-infected Chinese
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IL27 blocking peptidePathways associated with IL27 blocking peptide
 Reference Product  PubMed Publications
 EBI3 blocking peptide  >74 publications with IL27 and EBI3
 IL27RA blocking peptide  >66 publications with IL27 and IL27RA
 TBX21 blocking peptide  >20 publications with IL27 and TBX21
 IL23A blocking peptide  >13 publications with IL27 and IL23A
 IL6ST blocking peptide  >8 publications with IL27 and IL6ST
 IL23R blocking peptide  >2 publications with IL27 and IL23R
 DMBT1 blocking peptide  >2 publications with IL27 and DMBT1
 STAT6 blocking peptide  >2 publications with IL27 and STAT6
 IL12RB2 blocking peptide  >1 publications with IL27 and IL12RB2
 IDO1 blocking peptide  >1 publications with IL27 and IDO1
 Products by Pathway  Pathway Diagram
 IL27-mediated Signaling Events Pathway antibodies  IL27-mediated Signaling Events Pathway Diagram
Diseases associated with IL27 blocking peptideOrgans/Tissues associated with IL27 blocking peptide
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >161 publications with IL27 and Inflammation
 Necrosis Antibodies  >48 publications with IL27 and Necrosis
 Encephalomyelitis, Autoimmune, Experimental Antibodies  >31 publications with IL27 and Encephalomyelitis, Autoimmune, Experimental
 Liver Diseases Antibodies  >21 publications with IL27 and Liver Diseases
 Colitis Antibodies  >17 publications with IL27 and Colitis
 Arthritis, Experimental Antibodies  >13 publications with IL27 and Arthritis, Experimental
 Death Antibodies  >10 publications with IL27 and Death
 Heart Diseases Antibodies  >8 publications with IL27 and Heart Diseases
 Kidney Diseases Antibodies  >8 publications with IL27 and Kidney Diseases
 Diabetes Mellitus, Type 1 Antibodies  >7 publications with IL27 and Diabetes Mellitus, Type 1
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >30 publications with IL27 and Lung
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