Q8N201.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
244,297 Da
NCBI Official Full Name
Integrator complex subunit 1
NCBI Official Synonym Full Names
integrator complex subunit 1
NCBI Official Synonym Symbols
NCBI Protein Information
integrator complex subunit 1
UniProt Protein Name
Integrator complex subunit 1
UniProt Synonym Gene Names
UniProt Entry Name
INT1_HUMAN
NCBI Summary for INTS1
INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
UniProt Comments for INTS1
INTS1: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Belongs to the Integrator subunit 1 family.
Protein type: RNA processing; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7p22.3
Cellular Component: integrator complex; membrane; nucleoplasm
Biological Process: snRNA processing; snRNA transcription from RNA polymerase II promoter
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Pathways associated with INTS1 blocking peptide
Diseases associated with INTS1 blocking peptide
Organs/Tissues associated with INTS1 blocking peptide
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