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IRF4 blocking peptide

Scan QR to view Datasheet Catalog #    MBS151926
Western Blot (WB)
Unit / Price
0.05 mg  /  $140 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IRF4, Blocking Peptide

★Popular Item★
 Also Known As   

IRF4 Peptide

 Product Synonym Names    MUM1; LSIRF; NF-EM5; MUM1; Interferon regulatory factor 4; Lymphocyte-specific interferon regulatory factor; IRF-4; interferon regulatory factor 4
 Product Gene Name   

IRF4 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    IRF4 peptide (MBS151926) is used for blocking the activity of IRF4 antibody (MBS151469)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Western Blot Protocol    Western Blot Peptide Blocking Protocol
 OMIM    phenotype 601900
 3D Structure    ModBase 3D Structure for Q15306
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 Form/Format    Liquid
 Concentration    200 ug/mL (lot specific)
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 Species    Human
 Buffer    PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
 Location    16 amino acids near the carboxy terminus of human IRF4.
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 Preparation and Storage    Store IRF4 peptide at -20 degree C, stable for one year.
 Other Notes    Small volumes of IRF4 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for IRF4 blocking peptide   

Blocking (BL)

 Application Notes for IRF4 blocking peptide    IRF4 peptide is used for blocking the activity of IRF4 antibody.
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 Western Blot (WB) of IRF4 blocking peptide    Western blot analysis of TYW4 in rat brain tissue lysate with TYW4 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
IRF4 blocking peptide Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for IRF4. It may not necessarily be applicable to this product.
 NCBI GI #    167555104
 NCBI GeneID    3662
 NCBI Accession #    NP_002451 [Other Products]
 NCBI GenBank Nucleotide #    NM_002460.3 [Other Products]
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 UniProt Primary Accession #    Q15306 [Other Products]
 UniProt Secondary Accession #    Q5VUI7; Q99660 [Other Products]
 UniProt Related Accession #    Q15306 [Other Products]
 Molecular Weight    51,644 Da
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 NCBI Official Full Name    interferon regulatory factor 4 isoform 1
 NCBI Official Synonym Full Names    interferon regulatory factor 4
 NCBI Official Symbol    IRF4 [Similar Products]
 NCBI Official Synonym Symbols   
MUM1; LSIRF; SHEP8; NF-EM5
[Similar Products]
 NCBI Protein Information    interferon regulatory factor 4; multiple myeloma oncogene 1; lymphocyte-specific interferon regulatory factor
 UniProt Protein Name    Interferon regulatory factor 4
 UniProt Synonym Protein Names   
Lymphocyte-specific interferon regulatory factor; LSIRF; Multiple myeloma oncogene 1; NF-EM5
 Protein Family    Interferon regulatory factor
 UniProt Gene Name    IRF4 [Similar Products]
 UniProt Synonym Gene Names    MUM1; IRF-4; LSIRF [Similar Products]
 UniProt Entry Name    IRF4_HUMAN
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 NCBI Summary for IRF4    The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]
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 UniProt Comments for IRF4    IRF4: Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Interacts with SPIB and DEF6. Not induced by interferons. Lymphoid cells. Belongs to the IRF family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Oncoprotein; DNA-binding

Chromosomal Location of Human Ortholog: 6p25-p23

Cellular Component: nucleoplasm; membrane; cytoplasm; cytosol; nucleus

Molecular Function: protein binding; sequence-specific DNA binding; protein-lysine N-methyltransferase activity; transcription factor binding; transcription factor activity

Biological Process: transcription, DNA-dependent; T cell activation; positive regulation of interleukin-2 biosynthetic process; positive regulation of transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; regulation of T-helper cell differentiation; myeloid dendritic cell differentiation; defense response to protozoan; peptidyl-lysine methylation; positive regulation of interleukin-10 biosynthetic process; positive regulation of interleukin-4 biosynthetic process; positive regulation of interleukin-13 biosynthetic process; negative regulation of toll-like receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of DNA binding

Disease: Skin/hair/eye Pigmentation, Variation In, 8
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 Research Articles on IRF4    1. Increased IRF4 expression correlates with childhood leukemia severity and relapse.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IRF4 blocking peptidePathways associated with IRF4 blocking peptide
 Reference Product  PubMed Publications
 BCL6 blocking peptide  >73 publications with IRF4 and BCL6
 PRDM1 blocking peptide  >40 publications with IRF4 and PRDM1
 MYD88 blocking peptide  >7 publications with IRF4 and MYD88
 STAT6 blocking peptide  >7 publications with IRF4 and STAT6
 MAF blocking peptide  >5 publications with IRF4 and MAF
 SPI1 blocking peptide  >4 publications with IRF4 and SPI1
 CIITA blocking peptide  >3 publications with IRF4 and CIITA
 NFATC2 blocking peptide  >3 publications with IRF4 and NFATC2
 STAT2 blocking peptide  >1 publications with IRF4 and STAT2
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Alpha/beta Signaling Pathway antibodies  Interferon Alpha/beta Signaling Pathway Diagram
 Interferon Gamma Signaling Pathway antibodies  Interferon Gamma Signaling Pathway Diagram
 TCR Signaling Pathway antibodies  TCR Signaling Pathway Diagram
 Type II Interferon Signaling (IFNG) Pathway antibodies  Type II Interferon Signaling (IFNG) Pathway Diagram
Diseases associated with IRF4 blocking peptideOrgans/Tissues associated with IRF4 blocking peptide
 Disease Name  Pubmed Publications
 Multiple Myeloma Antibodies  >63 publications with IRF4 and Multiple Myeloma
 Inflammation Antibodies  >46 publications with IRF4 and Inflammation
 Skin Neoplasms Antibodies  >27 publications with IRF4 and Skin Neoplasms
 Leukemia, Lymphocytic, Chronic, B-Cell Antibodies  >21 publications with IRF4 and Leukemia, Lymphocytic, Chronic, B-Cell
 Disease Models, Animal Antibodies  >18 publications with IRF4 and Disease Models, Animal
 Cell Transformation, Neoplastic Antibodies  >16 publications with IRF4 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >15 publications with IRF4 and Neoplasms, Experimental
 Necrosis Antibodies  >14 publications with IRF4 and Necrosis
 Colitis Antibodies  >10 publications with IRF4 and Colitis
 Hyperplasia Antibodies  >6 publications with IRF4 and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >259 publications with IRF4 and Blood
 Lymph Node Antibodies  >71 publications with IRF4 and Lymph Node
 Skin Antibodies  >40 publications with IRF4 and Skin
 Lymph Antibodies  >34 publications with IRF4 and Lymph
 Spleen Antibodies  >27 publications with IRF4 and Spleen
 Lung Antibodies  >18 publications with IRF4 and Lung
 Eye Antibodies  >15 publications with IRF4 and Eye
 Heart Antibodies  >12 publications with IRF4 and Heart
 Kidney Antibodies  >11 publications with IRF4 and Kidney
 Pharynx Antibodies  >9 publications with IRF4 and Pharynx
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