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KAL1 blocking peptide

Scan QR to view Datasheet Catalog #    MBS9224077 KAL1 blocking peptide
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KAL1, Blocking Peptide

 Also Known As   

KAL1 Antibody (N-term) Blocking Peptide

 Product Synonym Names    Anosmin-1; Adhesion molecule-like X-linked; Kallmann syndrome protein; KAL1; ADMLX; KAL; KALIG1
 Product Gene Name   

KAL1 blocking peptide

[Similar Products]
 Product Synonym Gene Name    ADMLX; KAL; KALIG1 [Similar Products]
 Antibody/Peptide Pairs    KAL1 peptide (MBS9224077) is used for blocking the activity of KAL1 antibody (MBS9212093)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    300836
 3D Structure    ModBase 3D Structure for P23352
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 Form/Format    Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
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 Cellular Location    Cell membrane; Peripheral membrane protein. Secreted. Note: Proteolytic cleavage may release it from the cell surface into the extracellular space
 Tissue Location    Expressed in the cerebellum (at protein level).
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of KAL1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for KAL1 blocking peptide

   Has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex (By similarity). Chemoattractant for fetal olfactory epithelial cells.
NCBI/Uniprot data below describe general gene information for KAL1. It may not necessarily be applicable to this product.
 NCBI GI #    134048661
 NCBI GeneID    3730
 NCBI Accession #    P23352.3 [Other Products]
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 UniProt Primary Accession #    P23352 [Other Products]
 UniProt Secondary Accession #    B2RPF8 [Other Products]
 UniProt Related Accession #    P23352 [Other Products]
 Molecular Weight    76,112 Da
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 NCBI Official Full Name    Anosmin-1
 NCBI Official Synonym Full Names    anosmin 1
 NCBI Official Symbol    ANOS1 [Similar Products]
 NCBI Official Synonym Symbols   
HH1; HHA; KAL; KMS; KAL1; ADMLX; WFDC19; KALIG-1
[Similar Products]
 NCBI Protein Information    anosmin-1
 UniProt Protein Name    Anosmin-1
 UniProt Synonym Protein Names   
Adhesion molecule-like X-linked; Kallmann syndrome protein
 UniProt Gene Name    ANOS1 [Similar Products]
 UniProt Entry Name    KALM_HUMAN
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 NCBI Summary for KAL1    Mutations in this gene cause the X-linked Kallmann syndrome. The encoded protein is similar in sequence to proteins known to function in neural cell adhesion and axonal migration. In addition, this cell surface protein is N-glycosylated and may have anti-protease activity. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KAL1    KAL1: Has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex. Chemoattractant for fetal olfactory epithelial cells. Defects in KAL1 are the cause of Kallmann syndrome type 1 (KAL1); also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin- releasing hormone-synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous.

Protein type: Motility/polarity/chemotaxis; Extracellular matrix

Chromosomal Location of Human Ortholog: Xp22.32

Cellular Component: extracellular region; extracellular space; proteinaceous extracellular matrix

Molecular Function: extracellular matrix structural constituent; protein binding

Biological Process: axon guidance; cell motility; chemotaxis; fibroblast growth factor receptor signaling pathway

Disease: Hypogonadotropic Hypogonadism 1 With Or Without Anosmia
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 Research Articles on KAL1    1. data indicated KAL1 plays potential suppressive role on OSCC initiation and progression. KAL1 gene may serve as adjuvant biomarker for identification of pathological grade.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with KAL1 blocking peptideDiseases associated with KAL1 blocking peptide
 Products by Pathway  Pathway Diagram
 FGFR1 Ligand Binding And Activation Pathway antibodies  FGFR1 Ligand Binding And Activation Pathway Diagram
 FGFR1c Ligand Binding And Activation Pathway antibodies  FGFR1c Ligand Binding And Activation Pathway Diagram
 Negative Regulation Of FGFR1 Signaling Pathway antibodies  Negative Regulation Of FGFR1 Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By FGFR Pathway antibodies  Signaling By FGFR Pathway Diagram
 Signaling By FGFR1 Pathway antibodies  Signaling By FGFR1 Pathway Diagram
 Disease Name  Pubmed Publications
 Kallmann Syndrome Antibodies  >1 publications with KAL1 and Kallmann Syndrome
Organs/Tissues associated with KAL1 blocking peptide
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1 publications with KAL1 and Brain
 Embryonic Tissue Antibodies  >1 publications with KAL1 and Embryonic Tissue
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