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KRT1 blocking peptide

Scan QR to view Datasheet Catalog #    MBS9228346 KRT1 blocking peptide
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KRT1, Blocking Peptide

 Also Known As   

KRT1 Antibody (Center) Blocking Peptide

 Product Synonym Names    Keratin; type II cytoskeletal 1; 67 kDa cytokeratin; Cytokeratin-1; CK-1; Hair alpha protein; Keratin-1; K1; Type-II keratin Kb1; KRT1; KRTA
 Product Gene Name   

KRT1 blocking peptide

[Similar Products]
 Product Synonym Gene Name    KRTA [Similar Products]
 Antibody/Peptide Pairs    KRT1 peptide (MBS9228346) is used for blocking the activity of KRT1 antibody (MBS9212937)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    113800
 3D Structure    ModBase 3D Structure for P04264
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 Form/Format    Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
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 Cellular Location    Cell membrane. Note: Located on plasma membrane of neuroblastoma NMB7 cells
 Tissue Location    The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of KRT1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for KRT1 blocking peptide

   May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.
NCBI/Uniprot data below describe general gene information for KRT1. It may not necessarily be applicable to this product.
 NCBI GI #    238054406
 NCBI GeneID    3848
 NCBI Accession #    P04264.6 [Other Products]
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 UniProt Primary Accession #    P04264 [Other Products]
 UniProt Secondary Accession #    P85925; P86104; Q14720; Q6GSJ0; Q9H298; B2RA01 [Other Products]
 UniProt Related Accession #    P04264 [Other Products]
 Molecular Weight    66,039 Da
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 NCBI Official Full Name    Keratin, type II cytoskeletal 1
 NCBI Official Synonym Full Names    keratin 1
 NCBI Official Symbol    KRT1 [Similar Products]
 NCBI Official Synonym Symbols   
K1; CK1; EHK; EHK1; EPPK; KRT1A; NEPPK
[Similar Products]
 NCBI Protein Information    keratin, type II cytoskeletal 1
 UniProt Protein Name    Keratin, type II cytoskeletal 1
 UniProt Synonym Protein Names   
67 kDa cytokeratin; Cytokeratin-1; CK-1; Hair alpha protein; Keratin-1; K1; Type-II keratin Kb1
 Protein Family    Keratin
 UniProt Gene Name    KRT1 [Similar Products]
 UniProt Synonym Gene Names    KRTA; CK-1; K1 [Similar Products]
 UniProt Entry Name    K2C1_HUMAN
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 NCBI Summary for KRT1    The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KRT1    K1: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K10.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: cytoskeleton; extracellular matrix; extracellular space; membrane; nucleus

Molecular Function: carbohydrate binding; protein binding

Biological Process: complement activation, lectin pathway; retinal homeostasis

Disease: Epidermolytic Hyperkeratosis; Ichthyosis Hystrix, Curth-macklin Type; Ichthyosis, Cyclic, With Epidermolytic Hyperkeratosis; Keratosis Palmoplantaris Striata Iii; Palmoplantar Keratoderma, Epidermolytic; Palmoplantar Keratoderma, Nonepidermolytic
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 Research Articles on KRT1    1. Complete structure of an epithelial keratin 1/keratin 10 dimer has been presented.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with KRT1 blocking peptidePathways associated with KRT1 blocking peptide
 Reference Product  PubMed Publications
 KRT10 blocking peptide  >66 publications with KRT1 and KRT10
 CTNNB1 blocking peptide  >11 publications with KRT1 and CTNNB1
 KRT2 blocking peptide  >10 publications with KRT1 and KRT2
 UBC blocking peptide  >1 publications with KRT1 and UBC
 IVL blocking peptide  >1 publications with KRT1 and IVL
 LOR blocking peptide  >1 publications with KRT1 and LOR
 LEF1 blocking peptide  >1 publications with KRT1 and LEF1
 Products by Pathway  Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies  Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
Diseases associated with KRT1 blocking peptideOrgans/Tissues associated with KRT1 blocking peptide
 Disease Name  Pubmed Publications
 Skin Neoplasms Antibodies  >49 publications with KRT1 and Skin Neoplasms
 Hyperkeratosis, Epidermolytic Antibodies  >42 publications with KRT1 and Hyperkeratosis, Epidermolytic
 Inflammation Antibodies  >36 publications with KRT1 and Inflammation
 Carcinoma, Squamous Cell Antibodies  >27 publications with KRT1 and Carcinoma, Squamous Cell
 Hyperplasia Antibodies  >26 publications with KRT1 and Hyperplasia
 Keratoderma, Palmoplantar, Epidermolytic Antibodies  >23 publications with KRT1 and Keratoderma, Palmoplantar, Epidermolytic
 Immune System Diseases Antibodies  >20 publications with KRT1 and Immune System Diseases
 Necrosis Antibodies  >12 publications with KRT1 and Necrosis
 Cell Transformation, Neoplastic Antibodies  >12 publications with KRT1 and Cell Transformation, Neoplastic
 Lung Diseases Antibodies  >10 publications with KRT1 and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >256 publications with KRT1 and Skin
 Blood Antibodies  >55 publications with KRT1 and Blood
 Mouth Antibodies  >35 publications with KRT1 and Mouth
 Thymus Antibodies  >14 publications with KRT1 and Thymus
 Lung Antibodies  >12 publications with KRT1 and Lung
 Brain Antibodies  >7 publications with KRT1 and Brain
 Mammary Gland Antibodies  >7 publications with KRT1 and Mammary Gland
 Bladder Antibodies  >4 publications with KRT1 and Bladder
 Uterus Antibodies  >3 publications with KRT1 and Uterus
 Heart Antibodies  >2 publications with KRT1 and Heart
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