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KLK8 blocking peptide :: Kallikrein 8 Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS9226062 KLK8 blocking peptide
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Kallikrein 8 (KLK8), Blocking Peptide

 Also Known As   

Kallikrein 8 Antibody (Center) Blocking peptide

 Product Synonym Names    Kallikrein-8; hK8; Neuropsin; NP; Ovasin; Serine protease 19; Serine protease TADG-14; Tumor-associated differentially expressed gene 14 protein; KLK8; NRPN; PRSS19; TADG14
 Product Gene Name   

KLK8 blocking peptide

[Similar Products]
 Product Synonym Gene Name    NRPN; PRSS19; TADG14 [Similar Products]
 Antibody/Peptide Pairs    Kallikrein 8 peptide (MBS9226062) is used for blocking the activity of Kallikrein 8 antibody (MBS9215041)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605644
 3D Structure    ModBase 3D Structure for O60259
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 Specificity    The synthetic peptide sequence used to generate the antibody was selected from the Center region of human KLK8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
 Form/Format    The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
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 Cellular Location    Secreted. Cytoplasm. Note: Shows a cytoplasmic distribution in the keratinocytes
 Tissue Location    Isoform 1 is predominantly expressed in the pancreas. Isoform 2 is expressed in adult brain and hippocampus Isoform 1 and isoform 2 are found in fetal brain and placenta Detected in salivary gland, uterus, thymus, breast, testis and kidney but not in spleen, liver, lung or normal ovarian tissue Displays an 11.5-fold increase in Alzheimer disease hippocampus compared to controls and is overexpressed in some ovarian carcinomas. Expressed at low levels in normal skin while high levels are found in psoriasis vulgaris, seborrheic keratosis, lichen planus and squamous cell carcinoma skin samples. Expressed in the keratinocytes.
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of KLK8 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for KLK8 blocking peptide

   Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer- collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.
NCBI/Uniprot data below describe general gene information for KLK8. It may not necessarily be applicable to this product.
 NCBI GI #    6093536
 NCBI GeneID    11202
 NCBI Accession #    O60259.1 [Other Products]
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 UniProt Primary Accession #    O60259 [Other Products]
 UniProt Secondary Accession #    Q5V9X1; Q5V9X2; Q8IW69; Q9HCB3; Q9NR68; Q9NR69; Q9UIL9; Q9UQ47 [Other Products]
 UniProt Related Accession #    O60259 [Other Products]
 Molecular Weight    3,653 Da
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 NCBI Official Full Name    Kallikrein-8
 NCBI Official Synonym Full Names    kallikrein related peptidase 8
 NCBI Official Symbol    KLK8 [Similar Products]
 NCBI Official Synonym Symbols   
NP; HNP; NRPN; PRSS19; TADG14
[Similar Products]
 NCBI Protein Information    kallikrein-8
 UniProt Protein Name    Kallikrein-8
 UniProt Synonym Protein Names   
Neuropsin; NP; Ovasin; Serine protease 19; Serine protease TADG-14; Tumor-associated differentially expressed gene 14 protein
 Protein Family    Kallikrein
 UniProt Gene Name    KLK8 [Similar Products]
 UniProt Synonym Gene Names    NRPN; PRSS19; TADG14; hK8; NP [Similar Products]
 UniProt Entry Name    KLK8_HUMAN
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 NCBI Summary for KLK8    Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
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 UniProt Comments for KLK8    KLK8: Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer- collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. Belongs to the peptidase S1 family. Kallikrein subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; EC 3.4.21.118; Cell development/differentiation; Secreted; Protease

Chromosomal Location of Human Ortholog: 19q13

Cellular Component: cytoplasm; extracellular space

Molecular Function: protein binding; serine-type endopeptidase activity

Biological Process: cell death; keratinocyte proliferation; memory; negative regulation of axon regeneration; negative regulation of myelination; neurite morphogenesis; regulation of synapse organization and biogenesis; response to wounding
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 Research Articles on KLK8    1. KLK8 mRNA expression is associated with aggressive tumor characteristics and it can serve as a novel independent biomarker of unfavorable prognosis for BC patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with KLK8 blocking peptideDiseases associated with KLK8 blocking peptide
 Products by Pathway  Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >17 publications with KLK8 and Carcinoma
 Breast Neoplasms Antibodies  >6 publications with KLK8 and Breast Neoplasms
 Adenocarcinoma Antibodies  >6 publications with KLK8 and Adenocarcinoma
 Inflammation Antibodies  >6 publications with KLK8 and Inflammation
 Lung Neoplasms Antibodies  >4 publications with KLK8 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >2 publications with KLK8 and Neoplasms, Experimental
 Seizures Antibodies  >2 publications with KLK8 and Seizures
 Hypertrophy Antibodies  >2 publications with KLK8 and Hypertrophy
 Uterine Cervical Neoplasms Antibodies  >1 publications with KLK8 and Uterine Cervical Neoplasms
 Memory Disorders Antibodies  >1 publications with KLK8 and Memory Disorders
Organs/Tissues associated with KLK8 blocking peptide
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >50 publications with KLK8 and Brain
 Skin Antibodies  >35 publications with KLK8 and Skin
 Lung Antibodies  >5 publications with KLK8 and Lung
 Esophagus Antibodies  >5 publications with KLK8 and Esophagus
 Uterus Antibodies  >4 publications with KLK8 and Uterus
 Placenta Antibodies  >2 publications with KLK8 and Placenta
 Mammary Gland Antibodies  >2 publications with KLK8 and Mammary Gland
 Liver Antibodies  >2 publications with KLK8 and Liver
 Lymph Node Antibodies  >1 publications with KLK8 and Lymph Node
 Stomach Antibodies  >1 publications with KLK8 and Stomach
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