AAH19334
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,387 Da
NCBI Official Full Name
Serine/threonine kinase 11
NCBI Official Synonym Full Names
serine/threonine kinase 11
NCBI Protein Information
serine/threonine-protein kinase STK11; liver kinase B1; polarization-related protein LKB1; renal carcinoma antigen NY-REN-19; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1
UniProt Protein Name
Serine/threonine-protein kinase STK11
UniProt Synonym Protein Names
Liver kinase B1; LKB1; hLKB1; Renal carcinoma antigen NY-REN-19
UniProt Synonym Gene Names
UniProt Entry Name
STK11_HUMAN
NCBI Summary for STK11
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for STK11
LKB1: a S/T protein kinase of the CAMKL family. A tumor suppressor that helps control cell structure, polarity, apoptosis and energy homeostasis. Phosphorylates AGS3 (activator of G-protein signaling 3) GPR domains, regulating the interaction of GPR-containing proteins with G-proteins. A cytosolic protein complex comprised of LKB1, the pseudokinase STRAD, and the MO25 scaffold protein. Activates AMPK and several related protein kinases. AMPK plays a predominant role as the master regulator of cellular energy homeostasis, controlling downstream effectors that regulate cell growth and apoptosis in response to cellular ATP concentrations. The Lkb1/Strad/Mo25 complex can polarize single epithelial cells, leading to the formation of a brush border containing microvilli on the apical surface. Mutation in the corresponding gene causes Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by benign GI tract polyps and dark skin lesions of the mouth, hands and feet. A variety of other LKB1 gene mutations have been associated with the formation of sporadic cancers in several tissues.
Protein type: Tumor suppressor; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; Kinase, protein; Autophagy; EC 2.7.11.1; CAMK group; CAMKL family; LKB subfamily
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: mitochondrion; membrane; cytoplasm; nucleus; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; p53 binding; magnesium ion binding; protein complex binding; protein kinase activator activity; ATP binding; LRR domain binding
Biological Process: response to glucagon stimulus; Golgi localization; protein heterooligomerization; protein amino acid autophosphorylation; Wnt receptor signaling pathway through beta-catenin; response to lipid; glucose homeostasis; T cell receptor signaling pathway; protein amino acid phosphorylation; anoikis; positive regulation of gluconeogenesis; negative regulation of cell proliferation; regulation of fatty acid biosynthetic process; vasculature development; tissue homeostasis; regulation of cell growth; cell cycle arrest; positive thymic T cell selection; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of Wnt receptor signaling pathway; regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; axonogenesis; establishment of cell polarity; activation of protein kinase activity; energy reserve metabolic process; insulin receptor signaling pathway; autophagy; positive regulation of axonogenesis; response to ionizing radiation; negative regulation of cell growth; response to DNA damage stimulus; spermatid development
Disease: Pancreatic Cancer; Testicular Germ Cell Tumor; Peutz-jeghers Syndrome
Research Articles on STK11
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Products associated with STK11 blocking peptide
Pathways associated with STK11 blocking peptide
Diseases associated with STK11 blocking peptide
Organs/Tissues associated with STK11 blocking peptide
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