Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Blocking Peptide rightarrow NR1H3  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • RPS27L Antibody
 • ARRD4 Antibody
 • M2-Cholinergic Receptor Antibodies (CHRM2) ELISA Kit
 • alpha2 Macroglobulin Precursor (PRE-alpha2 MG) ELISA Kit
 • Azurocidin 1 (AZU1) ELISA Kit
 • Alcohol Dehydrogenase (ADH) ELISA Kit
 • Fatty Acid Binding Protein 7, Brain (FABP7) ELISA Kit
 • A Proliferation Inducing Ligand (APRIL) ELISA Kit
 • Centriole and Centrosome Antibody (ACA) ELISA Kit
 • Heat Shock Protein 40 (HSP40) ELISA Kit
 • Growth Differentiation Factor 7 (GDF7) ELISA Kit
 • Serum Amyloid A (SAA) ELISA Kit
 • High-Temperature Requirement Factor A3 (HTRA3) ELISA Kit
 • Map Kinase Phosphatase 1 (MKP-1) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

NR1H3 blocking peptide :: LXR-A Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS153024 NR1H3 blocking peptide
Unit / Price
0.05 mg  /  $135 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LXR-A (NR1H3), Blocking Peptide

 Also Known As   

LXR-A Peptide

 Product Synonym Names    LXRA; LXR-a; RLD-1; LXRA; Oxysterols receptor LXR-alpha; Liver X receptor alpha; nuclear receptor subfamily 1, group H, member 3
 Product Gene Name   

NR1H3 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    LXR-A peptide (MBS153024) is used for blocking the activity of LXR-A antibody (MBS150555)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Western Blot Protocol    Western Blot Peptide Blocking Protocol
 OMIM    602423
 3D Structure    ModBase 3D Structure for Q13133
Section Bar
Section Bar
 Form/Format    Liquid
 Concentration    200 ug/mL (lot specific)
Section Bar
 Species    Human
 Buffer    PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
 Location    15 amino acids near the carboxy terminus of human LXR-A.
Section Bar
 Preparation and Storage    Store LXR-A peptide at -20 degree C, stable for one year.
 Other Notes    Small volumes of NR1H3 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Applications Tested/Suitable for NR1H3 blocking peptide   

Blocking (BL)

 Application Notes for NR1H3 blocking peptide    LXR-A peptide is used for blocking the activity of LXR-A antibody.
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for NR1H3. It may not necessarily be applicable to this product.
 NCBI GI #    194294517
 NCBI GeneID    10062
 NCBI Accession #    NP_005684 [Other Products]
 NCBI GenBank Nucleotide #    NM_005693.3 [Other Products]
Section Bar
 UniProt Primary Accession #    Q13133 [Other Products]
 UniProt Secondary Accession #    Q8IW13; Q96H87; A8K3J9; D3DQR1 [Other Products]
 UniProt Related Accession #    Q13133 [Other Products]
 Molecular Weight    45,692 Da
Table BarTOPTable Bar
 NCBI Official Full Name    oxysterols receptor LXR-alpha isoform 1
 NCBI Official Synonym Full Names    nuclear receptor subfamily 1, group H, member 3
 NCBI Official Symbol    NR1H3 [Similar Products]
 NCBI Official Synonym Symbols   
LXRA; LXR-a; RLD-1
[Similar Products]
 NCBI Protein Information    oxysterols receptor LXR-alpha; liver X nuclear receptor alpha variant 1
 UniProt Protein Name    Oxysterols receptor LXR-alpha
 UniProt Synonym Protein Names   
Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3
 Protein Family    Oxysterols receptor
 UniProt Gene Name    NR1H3 [Similar Products]
 UniProt Synonym Gene Names    LXRA [Similar Products]
 UniProt Entry Name    NR1H3_HUMAN
Section Bar
 NCBI Summary for NR1H3    The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Section Bar
 UniProt Comments for NR1H3    LXR-alpha: Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor; DNA-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: nucleoplasm; nuclear chromatin; nucleus; receptor complex

Molecular Function: ligand-dependent nuclear receptor activity; protein binding; sterol response element binding; DNA binding; zinc ion binding; sequence-specific DNA binding; transcription coactivator activity; cholesterol binding; steroid hormone receptor activity

Biological Process: negative regulation of lipid transport; positive regulation of fatty acid biosynthetic process; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; positive regulation of transcription, DNA-dependent; positive regulation of cellular protein metabolic process; positive regulation of toll-like receptor 4 signaling pathway; lipid homeostasis; negative regulation of pinocytosis; negative regulation of transcription from RNA polymerase II promoter; regulation of circadian rhythm; positive regulation of cholesterol transport; cholesterol homeostasis; negative regulation of inflammatory response; positive regulation of lipoprotein lipase activity; steroid hormone mediated signaling; gene expression; positive regulation of transcription from RNA polymerase II promoter; negative regulation of macrophage activation; response to progesterone stimulus; sterol homeostasis; apoptotic cell clearance
Table BarTOPTable Bar
 Research Articles on NR1H3    1. LXRalpha rather than LXRbeta plays a predominant role in mediating cholesterol efflux in human macrophages.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with NR1H3 blocking peptidePathways associated with NR1H3 blocking peptide
 Reference Product  PubMed Publications
 NR1H2 blocking peptide  >42 publications with NR1H3 and NR1H2
 ABCA1 blocking peptide  >18 publications with NR1H3 and ABCA1
 FASN blocking peptide  >6 publications with NR1H3 and FASN
 CYP7A1 blocking peptide  >3 publications with NR1H3 and CYP7A1
 REN blocking peptide  >3 publications with NR1H3 and REN
 ABCG8 blocking peptide  >2 publications with NR1H3 and ABCG8
 NR0B2 blocking peptide  >2 publications with NR1H3 and NR0B2
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 Nuclear Receptors In Lipid Metabolism And Toxicity Pathway antibodies  Nuclear Receptors In Lipid Metabolism And Toxicity Pathway Diagram
Diseases associated with NR1H3 blocking peptideOrgans/Tissues associated with NR1H3 blocking peptide
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >17 publications with NR1H3 and Fatty Liver
 Inflammation Antibodies  >12 publications with NR1H3 and Inflammation
 Liver Diseases Antibodies  >11 publications with NR1H3 and Liver Diseases
 Atherosclerosis Antibodies  >8 publications with NR1H3 and Atherosclerosis
 Cardiovascular Diseases Antibodies  >7 publications with NR1H3 and Cardiovascular Diseases
 Insulin Resistance Antibodies  >6 publications with NR1H3 and Insulin Resistance
 Hypercholesterolemia Antibodies  >5 publications with NR1H3 and Hypercholesterolemia
 Hypertriglyceridemia Antibodies  >4 publications with NR1H3 and Hypertriglyceridemia
 Dyslipidemias Antibodies  >3 publications with NR1H3 and Dyslipidemias
 Prenatal Exposure Delayed Effects Antibodies  >3 publications with NR1H3 and Prenatal Exposure Delayed Effects
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >74 publications with NR1H3 and Liver
 Blood Antibodies  >20 publications with NR1H3 and Blood
 Thyroid Antibodies  >8 publications with NR1H3 and Thyroid
 Brain Antibodies  >8 publications with NR1H3 and Brain
 Intestine Antibodies  >6 publications with NR1H3 and Intestine
 Heart Antibodies  >6 publications with NR1H3 and Heart
 Adipose Tissue Antibodies  >4 publications with NR1H3 and Adipose Tissue
 Mammary Gland Antibodies  >3 publications with NR1H3 and Mammary Gland
 Kidney Antibodies  >3 publications with NR1H3 and Kidney
 Pancreas Antibodies  >3 publications with NR1H3 and Pancreas
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions