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MEIS1 blocking peptide

Scan QR to view Datasheet Catalog #    MBS8243268 MEIS1 blocking peptide
Unit / Price
1 mg  /  $160 +1 FREE 8GB USB
5 mg  /  $305 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MEIS1, Blocking Peptide

 Also Known As   

MEIS1 Blocking Peptide

 Product Synonym Names    Homeobox protein Meis1
 Product Gene Name   

MEIS1 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    MEIS1 peptide (MBS8243268) is used for blocking the activity of MEIS1 antibody (MBS8242584)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601739
 3D Structure    ModBase 3D Structure for O00470
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 Host    Synthetic
 Species Reactivity    Human, Mouse
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 Purity/Purification    >85%
 Form/Format    Lyophilized Powder
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 Quality Control    The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Other Notes    Small volumes of MEIS1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for MEIS1 blocking peptide

   The peptide is used to block Anti-MEIS1 Antibody reactivity.
 Applications Tested/Suitable for MEIS1 blocking peptide   

Blocking (BL)

 Application Notes for MEIS1 blocking peptide    Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
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NCBI/Uniprot data below describe general gene information for MEIS1. It may not necessarily be applicable to this product.
 NCBI GI #    3024112
 NCBI GeneID    4211
 NCBI Accession #    O00470.1 [Other Products]
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 UniProt Primary Accession #    O00470 [Other Products]
 UniProt Secondary Accession #    A8MV50 [Other Products]
 UniProt Related Accession #    O00470 [Other Products]
 Molecular Weight    50,576 Da
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 NCBI Official Full Name    Homeobox protein Meis1
 NCBI Official Synonym Full Names    Meis homeobox 1
 NCBI Official Symbol    MEIS1 [Similar Products]
 NCBI Protein Information    homeobox protein Meis1
 UniProt Protein Name    Homeobox protein Meis1
 Protein Family    Homeobox protein
 UniProt Gene Name    MEIS1 [Similar Products]
 UniProt Entry Name    MEIS1_HUMAN
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 NCBI Summary for MEIS1    Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MEIS1    MEIS1: Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias. Defects in MEIS1 could be a cause of susceptibility to restless legs syndrome type 7 (RLS7). Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. Belongs to the TALE/MEIS homeobox family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 2p14

Cellular Component: nucleus; transcription factor complex

Molecular Function: chromatin binding; protein binding; protein heterodimerization activity; RNA polymerase II transcription factor activity, enhancer binding

Biological Process: angiogenesis; lens morphogenesis in camera-type eye; locomotory behavior; negative regulation of myeloid cell differentiation; negative regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter

Disease: Restless Legs Syndrome, Susceptibility To, 7
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 Research Articles on MEIS1    1. The NK AML patients with NPM1 mutations exhibited elevated HOXA4 methylation and expression levels of HOXA5 and MEIS1 compared with the NPM1 wildtype patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MEIS1 blocking peptidePathways associated with MEIS1 blocking peptide
 Reference Product  PubMed Publications
 HOXA9 blocking peptide  >142 publications with MEIS1 and HOXA9
 PBX1 blocking peptide  >68 publications with MEIS1 and PBX1
 HOXA10 blocking peptide  >25 publications with MEIS1 and HOXA10
 MYB blocking peptide  >13 publications with MEIS1 and MYB
 HOXA5 blocking peptide  >12 publications with MEIS1 and HOXA5
 HOXA11 blocking peptide  >4 publications with MEIS1 and HOXA11
 CREB1 blocking peptide  >3 publications with MEIS1 and CREB1
 STAT5A blocking peptide  >1 publications with MEIS1 and STAT5A
 STAT5B blocking peptide  >1 publications with MEIS1 and STAT5B
 Products by Pathway  Pathway Diagram
 Activation Of HOX Genes During Differentiation Pathway antibodies  Activation Of HOX Genes During Differentiation Pathway Diagram
 Activation Of Anterior HOX Genes In Hindbrain Development During Early Embryogenesis Pathway antibodies  Activation Of Anterior HOX Genes In Hindbrain Development During Early Embryogenesis Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
Diseases associated with MEIS1 blocking peptideOrgans/Tissues associated with MEIS1 blocking peptide
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >31 publications with MEIS1 and Disease Models, Animal
 Restless Legs Syndrome Antibodies  >29 publications with MEIS1 and Restless Legs Syndrome
 Immune System Diseases Antibodies  >27 publications with MEIS1 and Immune System Diseases
 Nervous System Diseases Antibodies  >24 publications with MEIS1 and Nervous System Diseases
 Chromosome Aberrations Antibodies  >16 publications with MEIS1 and Chromosome Aberrations
 Neoplasms, Experimental Antibodies  >9 publications with MEIS1 and Neoplasms, Experimental
 Congenital Abnormalities Antibodies  >9 publications with MEIS1 and Congenital Abnormalities
 Anemia Antibodies  >7 publications with MEIS1 and Anemia
 Kidney Diseases Antibodies  >5 publications with MEIS1 and Kidney Diseases
 Abnormalities, Multiple Antibodies  >4 publications with MEIS1 and Abnormalities, Multiple
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >77 publications with MEIS1 and Bone
 Brain Antibodies  >28 publications with MEIS1 and Brain
 Eye Antibodies  >19 publications with MEIS1 and Eye
 Heart Antibodies  >18 publications with MEIS1 and Heart
 Embryonic Tissue Antibodies  >17 publications with MEIS1 and Embryonic Tissue
 Vascular Antibodies  >15 publications with MEIS1 and Vascular
 Liver Antibodies  >11 publications with MEIS1 and Liver
 Muscle Antibodies  >10 publications with MEIS1 and Muscle
 Kidney Antibodies  >9 publications with MEIS1 and Kidney
 Lung Antibodies  >8 publications with MEIS1 and Lung
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