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MGST1 blocking peptide

Scan QR to view Datasheet Catalog #    MBS9224793 MGST1 blocking peptide
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MGST1, Blocking Peptide

 Also Known As   

MGST1 Antibody (Center) Blocking Peptide

 Product Synonym Names    Microsomal glutathione S-transferase 1; Microsomal GST-1; Microsomal GST-I; MGST1; GST12; MGST
 Product Gene Name   

MGST1 blocking peptide

[Similar Products]
 Product Synonym Gene Name    GST12; MGST [Similar Products]
 Antibody/Peptide Pairs    MGST1 peptide (MBS9224793) is used for blocking the activity of MGST1 antibody (MBS9206548)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    138330
 3D Structure    ModBase 3D Structure for P10620
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 Specificity    The synthetic peptide sequence used to generate the antibody was selected from the Center region of human MGST1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
 Form/Format    Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
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 Cellular Location    Microsome. Mitochondrion outer membrane; Peripheral membrane protein Endoplasmic reticulum membrane; Multi-pass membrane protein
 Tissue Location    Highly expressed in liver.
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of MGST1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for MGST1 blocking peptide

   Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.
NCBI/Uniprot data below describe general gene information for MGST1. It may not necessarily be applicable to this product.
 NCBI GI #    121740
 NCBI GeneID    4257
 NCBI Accession #    P10620.1 [Other Products]
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 UniProt Primary Accession #    P10620 [Other Products]
 UniProt Secondary Accession #    A8K533; G5EA53 [Other Products]
 UniProt Related Accession #    P10620 [Other Products]
 Molecular Weight    9,984 Da
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 NCBI Official Full Name    Microsomal glutathione S-transferase 1
 NCBI Official Synonym Full Names    microsomal glutathione S-transferase 1
 NCBI Official Symbol    MGST1 [Similar Products]
 NCBI Official Synonym Symbols   
MGST; GST12; MGST-I
[Similar Products]
 NCBI Protein Information    microsomal glutathione S-transferase 1
 UniProt Protein Name    Microsomal glutathione S-transferase 1
 UniProt Synonym Protein Names   
Microsomal GST-I
 Protein Family    Microsomal glutathione S-transferase
 UniProt Gene Name    MGST1 [Similar Products]
 UniProt Synonym Gene Names    GST12; MGST; Microsomal GST-1 [Similar Products]
 UniProt Entry Name    MGST1_HUMAN
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 NCBI Summary for MGST1    The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]
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 UniProt Comments for MGST1    MGST1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity. Belongs to the MAPEG family.

Protein type: Xenobiotic Metabolism - metabolism by cytochrome P450; Mitochondrial; EC 2.5.1.18; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Membrane protein, multi-pass; Membrane protein, integral; Other Amino Acids Metabolism - glutathione

Chromosomal Location of Human Ortholog: 12p12.3-p12.1

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; mitochondrion; peroxisomal membrane

Molecular Function: glutathione peroxidase activity; glutathione transferase activity; protein binding

Biological Process: xenobiotic metabolic process
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 Research Articles on MGST1    1. possibly marked variations in NB mitochondrial homeostasis, they also imply that the results of these earlier studies using NB cells are not transferable to other tumor and cell types that express MGST1 at high concentrations.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with MGST1 blocking peptideDiseases associated with MGST1 blocking peptide
 Products by Pathway  Pathway Diagram
 Aflatoxin Activation And Detoxification Pathway antibodies  Aflatoxin Activation And Detoxification Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Glutathione Conjugation Pathway antibodies  Glutathione Conjugation Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >10 publications with MGST1 and Inflammation
 Necrosis Antibodies  >4 publications with MGST1 and Necrosis
 Lung Neoplasms Antibodies  >3 publications with MGST1 and Lung Neoplasms
 Fatty Liver Antibodies  >2 publications with MGST1 and Fatty Liver
 Lung Diseases Antibodies  >2 publications with MGST1 and Lung Diseases
 Disease Models, Animal Antibodies  >2 publications with MGST1 and Disease Models, Animal
 Breast Neoplasms Antibodies  >2 publications with MGST1 and Breast Neoplasms
 Liver Diseases Antibodies  >1 publications with MGST1 and Liver Diseases
 Neoplasms, Experimental Antibodies  >1 publications with MGST1 and Neoplasms, Experimental
 Abnormalities, Drug-Induced Antibodies  >1 publications with MGST1 and Abnormalities, Drug-Induced
Organs/Tissues associated with MGST1 blocking peptide
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >49 publications with MGST1 and Liver
 Lung Antibodies  >7 publications with MGST1 and Lung
 Eye Antibodies  >5 publications with MGST1 and Eye
 Muscle Antibodies  >5 publications with MGST1 and Muscle
 Intestine Antibodies  >4 publications with MGST1 and Intestine
 Kidney Antibodies  >4 publications with MGST1 and Kidney
 Blood Antibodies  >4 publications with MGST1 and Blood
 Brain Antibodies  >4 publications with MGST1 and Brain
 Embryonic Tissue Antibodies  >4 publications with MGST1 and Embryonic Tissue
 Mammary Gland Antibodies  >4 publications with MGST1 and Mammary Gland
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