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MAP2K4 blocking peptide :: MKK4 Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS8244024 MAP2K4 blocking peptide
Unit / Price
1 mg  /  $160 +1 FREE 8GB USB
5 mg  /  $305 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MKK4 (MAP2K4), Blocking Peptide

 Also Known As   

MKK4 Blocking Peptide

 Product Synonym Names    JNKK1; MEK4; MKK4; PRKMK4; SEK1; SERK1; SKK1; Dual specificity mitogen-activated protein kinase kinase 4; MAP kinase kinase 4; MAPKK 4; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated protein kinase kinase 1; SAPK kinase 1; SAPKK-1; SAPKK1; c-Jun N-terminal kinase kinase 1; JNKK
 Product Gene Name   

MAP2K4 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    MKK4 peptide (MBS8244024) is used for blocking the activity of MKK4 antibody (MBS8241678)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601335
 3D Structure    ModBase 3D Structure for P45985
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 Host    Synthetic
 Species Reactivity    Human, Mouse, Monkey, Zebrafish
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 Purity/Purification    >85%
 Form/Format    Lyophilized Powder
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 Quality Control    The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Other Notes    Small volumes of MAP2K4 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for MAP2K4 blocking peptide

   The peptide is used to block Anti-MKK4 Antibody reactivity.
 Applications Tested/Suitable for MAP2K4 blocking peptide   

Blocking (BL)

 Application Notes for MAP2K4 blocking peptide    Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
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NCBI/Uniprot data below describe general gene information for MAP2K4. It may not necessarily be applicable to this product.
 NCBI GI #    1170596
 NCBI GeneID    6416
 NCBI Accession #    P45985.1 [Other Products]
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 UniProt Primary Accession #    P45985 [Other Products]
 UniProt Secondary Accession #    Q5U0B8; Q6FHX4; Q6P9H2; Q6PIE6; B2R7N7; B3KYB2; D3DTS5 [Other Products]
 UniProt Related Accession #    P45985 [Other Products]
 Molecular Weight    45,584 Da
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 NCBI Official Full Name    Dual specificity mitogen-activated protein kinase kinase 4
 NCBI Official Synonym Full Names    mitogen-activated protein kinase kinase 4
 NCBI Official Symbol    MAP2K4 [Similar Products]
 NCBI Official Synonym Symbols   
JNKK; MEK4; MKK4; SEK1; SKK1; JNKK1; SERK1; MAPKK4; PRKMK4; SAPKK1; SAPKK-1
[Similar Products]
 NCBI Protein Information    dual specificity mitogen-activated protein kinase kinase 4
 UniProt Protein Name    Dual specificity mitogen-activated protein kinase kinase 4
 UniProt Synonym Protein Names   
JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated protein kinase kinase 1; SAPK kinase 1; SAPKK-1; SAPKK1; c-Jun N-terminal kinase kinase 1; JNKK
 Protein Family    Dual specificity mitogen-activated protein kinase kinase
 UniProt Gene Name    MAP2K4 [Similar Products]
 UniProt Synonym Gene Names    JNKK1; MEK4; MKK4; PRKMK4; SEK1; SERK1; SKK1; MAP kinase kinase 4; MAPKK 4; MEK 4; SEK1; SAPK kinase 1; SAPKK-1; SAPKK1; JNKK [Similar Products]
 UniProt Entry Name    MP2K4_HUMAN
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 NCBI Summary for MAP2K4    This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
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 UniProt Comments for MAP2K4    MKK4: dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38 but not ERK1 or -2. Mediates cellular responses to various cellular stresses and inflammatory cytokines. Phosphorylation by Akt inhibits MKK4 and suppresses stress-activated signal transduction.

Protein type: Kinase, protein; Protein kinase, dual-specificity (non-receptor); Protein kinase, STE; EC 2.7.12.2; STE group; STE7 family

Chromosomal Location of Human Ortholog: 17p12

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: ATP binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity

Biological Process: activation of protein kinase activity; apoptosis; innate immune response; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; peptidyl-tyrosine phosphorylation; regulation of apoptosis; regulation of mitotic cell cycle; response to wounding; signal transduction; stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway
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 Research Articles on MAP2K4    1. The plasma level of protein MAP2K4 was found to suggestively associate negatively with the volume of the left entorhinal cortex in asymptomatic older twins.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with MAP2K4 blocking peptideDiseases associated with MAP2K4 blocking peptide
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Cellular Roles Of Anthrax Toxin Pathway antibodies  Cellular Roles Of Anthrax Toxin Pathway Diagram
 Ceramide Signaling Pathway antibodies  Ceramide Signaling Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >57 publications with MAP2K4 and Necrosis
 Adenocarcinoma Antibodies  >21 publications with MAP2K4 and Adenocarcinoma
 Inflammation Antibodies  >21 publications with MAP2K4 and Inflammation
 Breast Neoplasms Antibodies  >21 publications with MAP2K4 and Breast Neoplasms
 Ovarian Neoplasms Antibodies  >15 publications with MAP2K4 and Ovarian Neoplasms
 Lung Neoplasms Antibodies  >14 publications with MAP2K4 and Lung Neoplasms
 Pancreatic Neoplasms Antibodies  >13 publications with MAP2K4 and Pancreatic Neoplasms
 Brain Diseases Antibodies  >12 publications with MAP2K4 and Brain Diseases
 Lung Diseases Antibodies  >12 publications with MAP2K4 and Lung Diseases
 Neoplasms, Experimental Antibodies  >11 publications with MAP2K4 and Neoplasms, Experimental
Organs/Tissues associated with MAP2K4 blocking peptide
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >25 publications with MAP2K4 and Brain
 Lung Antibodies  >22 publications with MAP2K4 and Lung
 Liver Antibodies  >20 publications with MAP2K4 and Liver
 Muscle Antibodies  >18 publications with MAP2K4 and Muscle
 Prostate Antibodies  >16 publications with MAP2K4 and Prostate
 Kidney Antibodies  >14 publications with MAP2K4 and Kidney
 Vascular Antibodies  >10 publications with MAP2K4 and Vascular
 Skin Antibodies  >10 publications with MAP2K4 and Skin
 Bone Antibodies  >10 publications with MAP2K4 and Bone
 Nerve Antibodies  >9 publications with MAP2K4 and Nerve
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