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MMP19 blocking peptide

Scan QR to view Datasheet Catalog #    MBS9225956 MMP19 blocking peptide
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MMP19, Blocking Peptide

 Also Known As   

MMP19 Antibody (C-term) Blocking Peptide

 Product Synonym Names    Matrix metalloproteinase-19; MMP-19; 3424-; Matrix metalloproteinase RASI; Matrix metalloproteinase-18; MMP-18; MMP19; MMP18; RASI
 Product Gene Name   

MMP19 blocking peptide

[Similar Products]
 Product Synonym Gene Name    MMP18; RASI [Similar Products]
 Antibody/Peptide Pairs    MMP19 peptide (MBS9225956) is used for blocking the activity of MMP19 antibody (MBS9208985)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601807
 3D Structure    ModBase 3D Structure for Q99542
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 Specificity    The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human MMP19. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
 Form/Format    The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
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 Cellular Location    Secreted, extracellular space, extracellular matrix
 Tissue Location    Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of MMP19 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for MMP19 blocking peptide

   Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.
NCBI/Uniprot data below describe general gene information for MMP19. It may not necessarily be applicable to this product.
 NCBI GI #    4505213
 NCBI GeneID    4327
 NCBI Accession #    NP_002420 [Other Products]
 NCBI GenBank Nucleotide #    NM_002429.5 [Other Products]
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 UniProt Primary Accession #    Q99542 [Other Products]
 UniProt Secondary Accession #    O15278; O95606; Q99580; B4E030 [Other Products]
 UniProt Related Accession #    Q99542 [Other Products]
 Molecular Weight    33,793 Da
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 NCBI Official Full Name    matrix metalloproteinase-19 isoform 1 preproprotein
 NCBI Official Synonym Full Names    matrix metallopeptidase 19
 NCBI Official Symbol    MMP19 [Similar Products]
 NCBI Official Synonym Symbols   
CODA; MMP18; RASI-1
[Similar Products]
 NCBI Protein Information    matrix metalloproteinase-19
 UniProt Protein Name    Matrix metalloproteinase-19
 UniProt Synonym Protein Names   
Matrix metalloproteinase RASI; Matrix metalloproteinase-18; MMP-18
 Protein Family    Matrix metalloproteinase
 UniProt Gene Name    MMP19 [Similar Products]
 UniProt Synonym Gene Names    MMP18; RASI; MMP-19; MMP-18 [Similar Products]
 UniProt Entry Name    MMP19_HUMAN
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 NCBI Summary for MMP19    This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]
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 UniProt Comments for MMP19    MMP19: Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin. May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients. Belongs to the peptidase M10A family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.-; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q14

Cellular Component: extracellular region

Molecular Function: serine-type endopeptidase activity

Biological Process: extracellular matrix disassembly

Disease: Cavitary Optic Disc Anomalies
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 Research Articles on MMP19    1. Triplication of an enhancer may lead to overexpression of MMP19 in the optic nerve that causes cavitary optic disc anomaly.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with MMP19 blocking peptideDiseases associated with MMP19 blocking peptide
 Products by Pathway  Pathway Diagram
 Collagen Degradation Pathway antibodies  Collagen Degradation Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Matrix Metalloproteinases Pathway antibodies  Matrix Metalloproteinases Pathway Diagram
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >5 publications with MMP19 and Lung Diseases
 Inflammation Antibodies  >5 publications with MMP19 and Inflammation
 Necrosis Antibodies  >5 publications with MMP19 and Necrosis
 Lung Neoplasms Antibodies  >3 publications with MMP19 and Lung Neoplasms
 Breast Neoplasms Antibodies  >3 publications with MMP19 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >2 publications with MMP19 and Cardiovascular Diseases
 Fibrosis Antibodies  >2 publications with MMP19 and Fibrosis
 Nervous System Diseases Antibodies  >2 publications with MMP19 and Nervous System Diseases
 Kidney Diseases Antibodies  >1 publications with MMP19 and Kidney Diseases
 Hypertrophy Antibodies  >1 publications with MMP19 and Hypertrophy
Organs/Tissues associated with MMP19 blocking peptide
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >8 publications with MMP19 and Lung
 Skin Antibodies  >5 publications with MMP19 and Skin
 Blood Antibodies  >5 publications with MMP19 and Blood
 Brain Antibodies  >4 publications with MMP19 and Brain
 Ovary Antibodies  >3 publications with MMP19 and Ovary
 Uterus Antibodies  >3 publications with MMP19 and Uterus
 Embryonic Tissue Antibodies  >3 publications with MMP19 and Embryonic Tissue
 Bone Antibodies  >3 publications with MMP19 and Bone
 Heart Antibodies  >1 publications with MMP19 and Heart
 Eye Antibodies  >1 publications with MMP19 and Eye
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