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MS4A1 blocking peptide

Scan QR to view Datasheet Catalog #    MBS9222151 MS4A1 blocking peptide
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MS4A1, Blocking Peptide

 Also Known As   

MS4A1 Antibody (C-term) Blocking Peptide

 Product Synonym Names    B-lymphocyte antigen CD20; B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD20; MS4A1; CD20
 Product Gene Name   

MS4A1 blocking peptide

[Similar Products]
 Product Synonym Gene Name    CD20 [Similar Products]
 Antibody/Peptide Pairs    MS4A1 peptide (MBS9222151) is used for blocking the activity of MS4A1 antibody (MBS9211573)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    112210
 3D Structure    ModBase 3D Structure for P11836
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 Form/Format    Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
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 Cellular Location    Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor
 Tissue Location    Expressed on B-cells.
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of MS4A1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for MS4A1 blocking peptide

   This protein may be involved in the regulation of B-cell activation and proliferation.
NCBI/Uniprot data below describe general gene information for MS4A1. It may not necessarily be applicable to this product.
 NCBI GI #    115968
 NCBI GeneID    931
 NCBI Accession #    P11836.1 [Other Products]
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 UniProt Primary Accession #    P11836 [Other Products]
 UniProt Secondary Accession #    P08984; Q13963; A6NMS4; B4DT24 [Other Products]
 UniProt Related Accession #    P11836 [Other Products]
 Molecular Weight    14,581 Da
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 NCBI Official Full Name    B-lymphocyte antigen CD20
 NCBI Official Synonym Full Names    membrane spanning 4-domains A1
 NCBI Official Symbol    MS4A1 [Similar Products]
 NCBI Official Synonym Symbols   
B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16
[Similar Products]
 NCBI Protein Information    B-lymphocyte antigen CD20
 UniProt Protein Name    B-lymphocyte antigen CD20
 UniProt Synonym Protein Names   
B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD_antigen: CD20
 Protein Family    B-lymphocyte antigen
 UniProt Gene Name    MS4A1 [Similar Products]
 UniProt Synonym Gene Names    CD20 [Similar Products]
 UniProt Entry Name    CD20_HUMAN
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 NCBI Summary for MS4A1    This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MS4A1    MS4A1: This protein may be involved in the regulation of B-cell activation and proliferation. Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5); also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. Belongs to the MS4A family.

Protein type: Cell surface; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: extracellular space

Molecular Function: protein binding

Disease: Immunodeficiency, Common Variable, 5
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 Research Articles on MS4A1    1. Case Report: aberrant CD20 expression by skin-infiltrating T cells using multispectral imaging.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with MS4A1 blocking peptideDiseases associated with MS4A1 blocking peptide
 Products by Pathway  Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >3 publications with MS4A1 and Adenocarcinoma
 Carcinoma Antibodies  >2 publications with MS4A1 and Carcinoma
 Atherosclerosis Antibodies  >2 publications with MS4A1 and Atherosclerosis
 Inflammation Antibodies  >2 publications with MS4A1 and Inflammation
 Carcinoma, Squamous Cell Antibodies  >1 publications with MS4A1 and Carcinoma, Squamous Cell
 Neoplasms, Experimental Antibodies  >1 publications with MS4A1 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >1 publications with MS4A1 and Breast Neoplasms
 Lung Diseases Antibodies  >1 publications with MS4A1 and Lung Diseases
 Heart Diseases Antibodies  >1 publications with MS4A1 and Heart Diseases
 Lung Neoplasms Antibodies  >1 publications with MS4A1 and Lung Neoplasms
Organs/Tissues associated with MS4A1 blocking peptide
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >15 publications with MS4A1 and Blood
 Kidney Antibodies  >3 publications with MS4A1 and Kidney
 Lung Antibodies  >3 publications with MS4A1 and Lung
 Vascular Antibodies  >1 publications with MS4A1 and Vascular
 Lymph Antibodies  >1 publications with MS4A1 and Lymph
 Pancreas Antibodies  >1 publications with MS4A1 and Pancreas
 Prostate Antibodies  >1 publications with MS4A1 and Prostate
 Connective Tissue Antibodies  >1 publications with MS4A1 and Connective Tissue
 Pharynx Antibodies  >1 publications with MS4A1 and Pharynx
 Tonsil Antibodies  >1 publications with MS4A1 and Tonsil
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