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Map2k4 blocking peptide

Scan QR to view Datasheet Catalog #    MBS9221232 Map2k4 blocking peptide
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Map2k4, Blocking Peptide

 Also Known As   

Mouse Map2k4 Antibody (C-term) Blocking Peptide

 Product Synonym Names    Dual specificity mitogen-activated protein kinase kinase 4; MAP kinase kinase 4; MAPKK 4; C-JUN N-terminal kinase kinase 1; JNK kinase 1; JNKK 1; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Map2k4; Jnkk1; Mek4; Mkk4; Prkmk4; Sek1; Serk1; Skk1
 Product Gene Name   

Map2k4 blocking peptide

[Similar Products]
 Product Synonym Gene Name    Jnkk1; Mek4; Mkk4; Prkmk4; Sek1; Serk1 [Similar Products]
 Antibody/Peptide Pairs    Map2k4 peptide (MBS9221232) is used for blocking the activity of Map2k4 antibody (MBS9206343)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P47809
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 Form/Format    Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
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 Cellular Location    Cytoplasm. Nucleus
 Tissue Location    Strong expression is detected in most of the central nervous system and in liver and thymus during early stages of development. While expression in nervous system increases over time, expression in fetal liver and thymus gradually decreases as embryogenesis proceeds. High level of expression in the central nervous system persists throughout postnatal development and remained at a stable level in adult brain
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of Map2k4 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Map2k4 blocking peptide

   Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.
NCBI/Uniprot data below describe general gene information for Map2k4. It may not necessarily be applicable to this product.
 NCBI GI #    2507202
 NCBI GeneID    26398
 NCBI Accession #    P47809.2 [Other Products]
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 UniProt Primary Accession #    P47809 [Other Products]
 UniProt Related Accession #    P47809 [Other Products]
 Molecular Weight    44,114 Da
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 NCBI Official Full Name    Dual specificity mitogen-activated protein kinase kinase 4
 NCBI Official Synonym Full Names    mitogen-activated protein kinase kinase 4
 NCBI Official Symbol    Map2k4 [Similar Products]
 NCBI Official Synonym Symbols   
MEK4; MKK4; Sek1; JNKK1; Serk1; PRKMK4
[Similar Products]
 NCBI Protein Information    dual specificity mitogen-activated protein kinase kinase 4
 UniProt Protein Name    Dual specificity mitogen-activated protein kinase kinase 4
 UniProt Synonym Protein Names   
C-JUN N-terminal kinase kinase 1; JNK kinase 1; JNKK 1; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1
 Protein Family    Dual specificity mitogen-activated protein kinase kinase
 UniProt Gene Name    Map2k4 [Similar Products]
 UniProt Synonym Gene Names    Jnkk1; Mek4; Mkk4; Prkmk4; Sek1; Serk1; Skk1; MAP kinase kinase 4; MAPKK 4; JNK kinase 1; JNKK 1; MEK 4; SEK1 [Similar Products]
 UniProt Entry Name    MP2K4_MOUSE
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 UniProt Comments for Map2k4    MKK4: dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38 but not ERK1 or -2. Mediates cellular responses to various cellular stresses and inflammatory cytokines. Phosphorylation by Akt inhibits MKK4 and suppresses stress-activated signal transduction.

Protein type: Protein kinase, dual-specificity (non-receptor); Protein kinase, STE; EC 2.7.12.2; Kinase, protein; STE group; STE7 family

Cellular Component: axon; cytoplasm; cytosol; dendrite cytoplasm; nucleus; perikaryon

Molecular Function: ATP binding; JUN kinase kinase activity; MAP kinase kinase activity; mitogen-activated protein kinase kinase kinase binding; protein binding; receptor signaling protein serine/threonine kinase activity

Biological Process: activation of JNK activity; JNK cascade; MAPKKK cascade; positive regulation of apoptosis; positive regulation of DNA replication; positive regulation of neuron apoptosis; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of protein amino acid phosphorylation; protein amino acid phosphorylation; response to wounding
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 Research Articles on Map2k4    1. Demonstrate that Mkk4 is a negative regulator of the TGF-beta1 signaling associated with atrial remodeling and arrhythmogenesis with age.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Map2k4 blocking peptideDiseases associated with Map2k4 blocking peptide
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >57 publications with Map2k4 and Necrosis
 Adenocarcinoma Antibodies  >21 publications with Map2k4 and Adenocarcinoma
 Inflammation Antibodies  >21 publications with Map2k4 and Inflammation
 Breast Neoplasms Antibodies  >21 publications with Map2k4 and Breast Neoplasms
 Lung Neoplasms Antibodies  >14 publications with Map2k4 and Lung Neoplasms
 Pancreatic Neoplasms Antibodies  >13 publications with Map2k4 and Pancreatic Neoplasms
 Prostatic Neoplasms Antibodies  >12 publications with Map2k4 and Prostatic Neoplasms
 Brain Diseases Antibodies  >12 publications with Map2k4 and Brain Diseases
 Lung Diseases Antibodies  >12 publications with Map2k4 and Lung Diseases
 Neoplasms, Experimental Antibodies  >11 publications with Map2k4 and Neoplasms, Experimental
Organs/Tissues associated with Map2k4 blocking peptide
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >49 publications with Map2k4 and Blood
 Brain Antibodies  >25 publications with Map2k4 and Brain
 Lung Antibodies  >22 publications with Map2k4 and Lung
 Liver Antibodies  >20 publications with Map2k4 and Liver
 Kidney Antibodies  >14 publications with Map2k4 and Kidney
 Skin Antibodies  >11 publications with Map2k4 and Skin
 Bone Antibodies  >10 publications with Map2k4 and Bone
 Lymph Node Antibodies  >6 publications with Map2k4 and Lymph Node
 Heart Antibodies  >6 publications with Map2k4 and Heart
 Embryonic Tissue Antibodies  >6 publications with Map2k4 and Embryonic Tissue
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