NP_001025186.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,822 Da
NCBI Official Full Name
melanopsin isoform 2
NCBI Official Synonym Full Names
opsin 4
NCBI Official Synonym Symbols
NCBI Protein Information
melanopsin; opsin-4
UniProt Protein Name
Melanopsin
UniProt Synonym Protein Names
Opsin-4
UniProt Synonym Gene Names
UniProt Entry Name
OPN4_HUMAN
NCBI Summary for OPN4
Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for OPN4
melanopsin: Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all- trans retinal back to 11-cis retinal. Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1
Chromosomal Location of Human Ortholog: 10q22
Cellular Component: integral to membrane; plasma membrane
Molecular Function: 11-cis retinal binding; G-protein coupled photoreceptor activity
Biological Process: rhodopsin mediated signaling; visual perception; rhythmic process; phototransduction; regulation of circadian rhythm; protein-chromophore linkage
Research Articles on OPN4
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Pathways associated with OPN4 blocking peptide
Diseases associated with OPN4 blocking peptide
Organs/Tissues associated with OPN4 blocking peptide
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