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NCK1 blocking peptide

Scan QR to view Datasheet Catalog #    MBS9220140 NCK1 blocking peptide
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NCK1, Blocking Peptide

 Also Known As   

NCK1 Antibody (N-term) Blocking peptide

 Product Synonym Names    Cytoplasmic protein NCK1; NCK adaptor protein 1; Nck-1; SH2/SH3 adaptor protein NCK-alpha; NCK1; NCK
 Product Gene Name   

NCK1 blocking peptide

[Similar Products]
 Product Synonym Gene Name    NCK [Similar Products]
 Antibody/Peptide Pairs    NCK1 peptide (MBS9220140) is used for blocking the activity of NCK1 antibody (MBS9214889)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600508
 3D Structure    ModBase 3D Structure for P16333
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 Specificity    The synthetic peptide sequence used to generate the antibody was selected from the N-term region of NCK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
 Form/Format    Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
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 Cellular Location    Cytoplasm. Endoplasmic reticulum. Nucleus. Note: Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of NCK1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for NCK1 blocking peptide

   Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.
NCBI/Uniprot data below describe general gene information for NCK1. It may not necessarily be applicable to this product.
 NCBI GI #    127962
 NCBI GeneID    4690
 NCBI Accession #    P16333.1 [Other Products]
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 UniProt Primary Accession #    P16333 [Other Products]
 UniProt Secondary Accession #    B7Z751; D3DNE3 [Other Products]
 UniProt Related Accession #    P16333 [Other Products]
 Molecular Weight    35,511 Da
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 NCBI Official Full Name    Cytoplasmic protein NCK1
 NCBI Official Synonym Full Names    NCK adaptor protein 1
 NCBI Official Symbol    NCK1 [Similar Products]
 NCBI Official Synonym Symbols   
NCK; nck-1; NCKalpha
[Similar Products]
 NCBI Protein Information    cytoplasmic protein NCK1
 UniProt Protein Name    Cytoplasmic protein NCK1
 UniProt Synonym Protein Names   
NCK adaptor protein 1; Nck-1; SH2/SH3 adaptor protein NCK-alpha
 Protein Family    Cytoplasmic protein
 UniProt Gene Name    NCK1 [Similar Products]
 UniProt Synonym Gene Names    NCK; Nck-1 [Similar Products]
 UniProt Entry Name    NCK1_HUMAN
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 NCBI Summary for NCK1    The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]
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 UniProt Comments for NCK1    NCK1: adapter protein containing Src homology 2 and 3 (SH2 and SH3) domains. Transduces signals from tyrosine-phosphorylated growth factor receptors to their cellular substrates.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3q21

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; plasma membrane; protein phosphatase type 1 complex; ribosome; trans-Golgi network

Molecular Function: ARF guanyl-nucleotide exchange factor activity; protein binding; protein binding, bridging; protein kinase inhibitor activity; receptor binding; receptor tyrosine kinase binding

Biological Process: negative regulation of peptidyl-serine phosphorylation; positive regulation of actin filament polymerization; positive regulation of T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; T cell activation; T cell receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; vesicle-mediated transport
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 Research Articles on NCK1    1. Results demonstrate that Nck acts as an important hub integrating angiogenic cues with cytoskeletal changes that enable endothelial apical-basal polarization and lumen formation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NCK1 blocking peptidePathways associated with NCK1 blocking peptide
 Reference Product  PubMed Publications
 EGFR blocking peptide  >2 publications with NCK1 and EGFR
 PDGFRB blocking peptide  >2 publications with NCK1 and PDGFRB
 WASL blocking peptide  >1 publications with NCK1 and WASL
 CBL blocking peptide  >1 publications with NCK1 and CBL
 PAK1 blocking peptide  >1 publications with NCK1 and PAK1
 Products by Pathway  Pathway Diagram
 Activation Of Rac Pathway antibodies  Activation Of Rac Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
Diseases associated with NCK1 blocking peptideOrgans/Tissues associated with NCK1 blocking peptide
 Disease Name  Pubmed Publications
 Carcinoma, Hepatocellular Antibodies  >5 publications with NCK1 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >4 publications with NCK1 and Liver Diseases
 Kidney Diseases Antibodies  >4 publications with NCK1 and Kidney Diseases
 Proteinuria Antibodies  >3 publications with NCK1 and Proteinuria
 Fever Antibodies  >2 publications with NCK1 and Fever
 Nervous System Diseases Antibodies  >2 publications with NCK1 and Nervous System Diseases
 Neoplasm Metastasis Antibodies  >2 publications with NCK1 and Neoplasm Metastasis
 Pain Antibodies  >1 publications with NCK1 and Pain
 Atrophy Antibodies  >1 publications with NCK1 and Atrophy
 Lung Neoplasms Antibodies  >1 publications with NCK1 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >1 publications with NCK1 and Eye
 Pancreas Antibodies  >1 publications with NCK1 and Pancreas
 Lung Antibodies  >1 publications with NCK1 and Lung
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