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OSM blocking peptide

Scan QR to view Datasheet Catalog #    MBS9220859 OSM blocking peptide
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

OSM, Blocking Peptide

 Also Known As   

OSM Antibody (C-term) Blocking Peptide

 Product Synonym Names    Oncostatin-M; OSM; OSM
 Product Gene Name   

OSM blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    OSM peptide (MBS9220859) is used for blocking the activity of OSM antibody (MBS9209905)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    165095
 3D Structure    ModBase 3D Structure for P13725
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 Form/Format    Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
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 Cellular Location    Secreted.
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of OSM blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for OSM blocking peptide

   Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).
NCBI/Uniprot data below describe general gene information for OSM. It may not necessarily be applicable to this product.
 NCBI GI #    129168
 NCBI GeneID    5008
 NCBI Accession #    P13725.2 [Other Products]
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 UniProt Primary Accession #    P13725 [Other Products]
 UniProt Secondary Accession #    Q6FHP8; Q9UCP6 [Other Products]
 UniProt Related Accession #    P13725 [Other Products]
 Molecular Weight    28,484 Da
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 NCBI Official Full Name    Oncostatin-M
 NCBI Official Synonym Full Names    oncostatin M
 NCBI Official Symbol    OSM [Similar Products]
 NCBI Protein Information    oncostatin-M
 UniProt Protein Name    Oncostatin-M
 Protein Family    Osmin
 UniProt Gene Name    OSM [Similar Products]
 UniProt Synonym Gene Names    OSM [Similar Products]
 UniProt Entry Name    ONCM_HUMAN
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 NCBI Summary for OSM    This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
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 UniProt Comments for OSM    OSM: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. Belongs to the LIF/OSM family.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: extracellular region

Molecular Function: cytokine activity; growth factor activity; oncostatin-M receptor binding

Biological Process: cell proliferation; multicellular organismal development; negative regulation of cell proliferation; negative regulation of hormone secretion; positive regulation of acute inflammatory response; positive regulation of cell proliferation; positive regulation of MAPKKK cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat3 protein
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 Research Articles on OSM    1. Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with OSM blocking peptidePathways associated with OSM blocking peptide
 Reference Product  PubMed Publications
 LIFR blocking peptide  >403 publications with OSM and LIFR
 STAT3 blocking peptide  >279 publications with OSM and STAT3
 CNTF blocking peptide  >188 publications with OSM and CNTF
 IL6ST blocking peptide  >182 publications with OSM and IL6ST
 IL11 blocking peptide  >84 publications with OSM and IL11
 OSMR blocking peptide  >80 publications with OSM and OSMR
 JAK2 blocking peptide  >49 publications with OSM and JAK2
 IL6 blocking peptide  >32 publications with OSM and IL6
 CTF1 blocking peptide  >1 publications with OSM and CTF1
 EPOR blocking peptide  >1 publications with OSM and EPOR
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL-6-type Cytokine Receptor Ligand Interactions Pathway antibodies  IL-6-type Cytokine Receptor Ligand Interactions Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-6 Family Signaling Pathway antibodies  Interleukin-6 Family Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Oncostatin M Signaling Pathway antibodies  Oncostatin M Signaling Pathway Diagram
Diseases associated with OSM blocking peptideOrgans/Tissues associated with OSM blocking peptide
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >230 publications with OSM and Inflammation
 Necrosis Antibodies  >159 publications with OSM and Necrosis
 Disease Models, Animal Antibodies  >78 publications with OSM and Disease Models, Animal
 Kidney Diseases Antibodies  >56 publications with OSM and Kidney Diseases
 Fibrosis Antibodies  >52 publications with OSM and Fibrosis
 Breast Neoplasms Antibodies  >49 publications with OSM and Breast Neoplasms
 Liver Neoplasms Antibodies  >45 publications with OSM and Liver Neoplasms
 Lung Diseases Antibodies  >44 publications with OSM and Lung Diseases
 Carcinoma, Hepatocellular Antibodies  >38 publications with OSM and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >29 publications with OSM and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >479 publications with OSM and Blood
 Kidney Antibodies  >130 publications with OSM and Kidney
 Lung Antibodies  >106 publications with OSM and Lung
 Intestine Antibodies  >24 publications with OSM and Intestine
 Ovary Antibodies  >17 publications with OSM and Ovary
 Thymus Antibodies  >17 publications with OSM and Thymus
 Uncharacterized Tissue Antibodies  >2 publications with OSM and Uncharacterized Tissue
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