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PDCD1LG2 blocking peptide :: PDL-2 Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS153072 PDCD1LG2 blocking peptide
Unit / Price
0.05 mg  /  $140 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PDL-2 (PDCD1LG2), Blocking Peptide

 Also Known As   

PDL-2 Peptide

 Product Synonym Names    B7DC; Btdc; PDL2; CD273; PD-L2; PDCD1L2; bA574F11.2; B7DC; Programmed cell death 1 ligand 2; Butyrophilin B7-DC; PD-1 ligand 2; programmed cell death 1 ligand 2
 Product Gene Name   

PDCD1LG2 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    PDL-2 peptide (MBS153072) is used for blocking the activity of PDL-2 antibody (MBS151188)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Western Blot Protocol    Western Blot Peptide Blocking Protocol
 OMIM    605723
 3D Structure    ModBase 3D Structure for Q9BQ51
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 Form/Format    Liquid
 Concentration    200 ug/mL (lot specific)
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 Species    Human
 Buffer    PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
 Location    16 amino acids near the center of human PDL-2
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 Preparation and Storage    Store PDL-2 peptide at -20 degree C, stable for one year.
 Other Notes    Small volumes of PDCD1LG2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for PDCD1LG2 blocking peptide   

Blocking (BL)

 Application Notes for PDCD1LG2 blocking peptide    The peptide is used for blocking the activity of PDL-2 antibody.
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NCBI/Uniprot data below describe general gene information for PDCD1LG2. It may not necessarily be applicable to this product.
 NCBI GI #    190014605
 NCBI GeneID    80380
 NCBI Accession #    NP_079515 [Other Products]
 NCBI GenBank Nucleotide #    NM_025239.3 [Other Products]
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 UniProt Primary Accession #    Q9BQ51 [Other Products]
 UniProt Secondary Accession #    Q14CN8; Q5T7Z6; Q6JXL8; Q6JXL9 [Other Products]
 UniProt Related Accession #    Q9BQ51 [Other Products]
 Molecular Weight    20,745 Da
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 NCBI Official Full Name    programmed cell death 1 ligand 2
 NCBI Official Synonym Full Names    programmed cell death 1 ligand 2
 NCBI Official Symbol    PDCD1LG2 [Similar Products]
 NCBI Official Synonym Symbols   
B7DC; Btdc; PDL2; CD273; PD-L2; PDCD1L2; bA574F11.2
[Similar Products]
 NCBI Protein Information    programmed cell death 1 ligand 2; B7-DC; PD-1 ligand 2; PD-1-ligand 2; PDCD1 ligand 2; butyrophilin B7-DC; programmed death ligand 2; B7 dendritic cell molecule
 UniProt Protein Name    Programmed cell death 1 ligand 2
 UniProt Synonym Protein Names   
Butyrophilin B7-DC; B7-DC; CD_antigen: CD273
 Protein Family    Programmed cell death
 UniProt Gene Name    PDCD1LG2 [Similar Products]
 UniProt Synonym Gene Names    B7DC; CD273; PDCD1L2; PDL2; PD-1 ligand 2; PD-L2; PDCD1 ligand 2; Programmed death ligand 2; B7-DC [Similar Products]
 UniProt Entry Name    PD1L2_HUMAN
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 UniProt Comments for PDCD1LG2    PDCD1LG2: Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9p24.2

Cellular Component: plasma membrane; integral to membrane; endomembrane system

Biological Process: negative regulation of interleukin-10 production; negative regulation of interferon-gamma production; negative regulation of activated T cell proliferation; T cell costimulation; positive regulation of T cell proliferation; immune response
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 Research Articles on PDCD1LG2    1. conclude that PD-L2 protein is robustly expressed by the majority of primary mediastinal (thymic) large B-cell lymphomas
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PDCD1LG2 blocking peptidePathways associated with PDCD1LG2 blocking peptide
 Reference Product  PubMed Publications
 PDCD1 blocking peptide  >98 publications with PDCD1LG2 and PDCD1
 CD4 blocking peptide  >66 publications with PDCD1LG2 and CD4
 CTLA4 blocking peptide  >21 publications with PDCD1LG2 and CTLA4
 CD40 blocking peptide  >15 publications with PDCD1LG2 and CD40
 BTLA blocking peptide  >2 publications with PDCD1LG2 and BTLA
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 PD-1 Signaling Pathway antibodies  PD-1 Signaling Pathway Diagram
Diseases associated with PDCD1LG2 blocking peptideOrgans/Tissues associated with PDCD1LG2 blocking peptide
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >28 publications with PDCD1LG2 and Inflammation
 Necrosis Antibodies  >16 publications with PDCD1LG2 and Necrosis
 Carcinoma Antibodies  >13 publications with PDCD1LG2 and Carcinoma
 Nervous System Diseases Antibodies  >12 publications with PDCD1LG2 and Nervous System Diseases
 Lung Diseases Antibodies  >12 publications with PDCD1LG2 and Lung Diseases
 Adenocarcinoma Antibodies  >8 publications with PDCD1LG2 and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >7 publications with PDCD1LG2 and Cardiovascular Diseases
 Liver Neoplasms Antibodies  >5 publications with PDCD1LG2 and Liver Neoplasms
 Kidney Diseases Antibodies  >4 publications with PDCD1LG2 and Kidney Diseases
 Lung Neoplasms Antibodies  >4 publications with PDCD1LG2 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >20 publications with PDCD1LG2 and Lung
 Brain Antibodies  >9 publications with PDCD1LG2 and Brain
 Vascular Antibodies  >8 publications with PDCD1LG2 and Vascular
 Heart Antibodies  >7 publications with PDCD1LG2 and Heart
 Placenta Antibodies  >4 publications with PDCD1LG2 and Placenta
 Thymus Antibodies  >2 publications with PDCD1LG2 and Thymus
 Uterus Antibodies  >2 publications with PDCD1LG2 and Uterus
 Ganglia Antibodies  >1 publications with PDCD1LG2 and Ganglia
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