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PELI2 blocking peptide

Scan QR to view Datasheet Catalog #    MBS9219445 PELI2 blocking peptide
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PELI2, Blocking Peptide

 Also Known As   

PELI2 Antibody (N-term) Blocking peptide

 Product Synonym Names    E3 ubiquitin-protein ligase pellino homolog 2; Pellino-2; 632-; PELI2
 Product Gene Name   

PELI2 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    PELI2 peptide (MBS9219445) is used for blocking the activity of PELI2 antibody (MBS9205376)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    614798
 3D Structure    ModBase 3D Structure for Q9HAT8
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 Form/Format    Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of PELI2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PELI2 blocking peptide

   E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7- dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.
NCBI/Uniprot data below describe general gene information for PELI2. It may not necessarily be applicable to this product.
 NCBI GI #    37999785
 NCBI GeneID    57161
 NCBI Accession #    Q9HAT8.1 [Other Products]
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 UniProt Primary Accession #    Q9HAT8 [Other Products]
 UniProt Secondary Accession #    B2RDY5 [Other Products]
 UniProt Related Accession #    Q9HAT8 [Other Products]
 Molecular Weight    46,435 Da
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 NCBI Official Full Name    E3 ubiquitin-protein ligase pellino homolog 2
 NCBI Official Synonym Full Names    pellino E3 ubiquitin protein ligase family member 2
 NCBI Official Symbol    PELI2 [Similar Products]
 NCBI Protein Information    E3 ubiquitin-protein ligase pellino homolog 2
 UniProt Protein Name    E3 ubiquitin-protein ligase pellino homolog 2
 Protein Family    E3 ubiquitin-protein ligase
 UniProt Gene Name    PELI2 [Similar Products]
 UniProt Synonym Gene Names    Pellino-2 [Similar Products]
 UniProt Entry Name    PELI2_HUMAN
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 UniProt Comments for PELI2    PELI2: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. Not required for NF-kappa-B activation. Belongs to the pellino family.

Protein type: Ubiquitin conjugating system; Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 14q21

Cellular Component: cytosol

Molecular Function: protein binding

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of MAPKKK cascade; positive regulation of protein amino acid phosphorylation
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 Research Articles on PELI2    1. A high-affinity Pellino2 e3 ubiquitin ligase binding domain is specific for phosphothreonine motifs.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PELI2 blocking peptideDiseases associated with PELI2 blocking peptide
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 IRAK1 Recruits IKK Complex Pathway antibodies  IRAK1 Recruits IKK Complex Pathway Diagram
 IRAK1 Recruits IKK Complex Upon TLR7/8 Or 9 Stimulation Pathway antibodies  IRAK1 Recruits IKK Complex Upon TLR7/8 Or 9 Stimulation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Interleukin-1 Signaling Pathway antibodies  Interleukin-1 Signaling Pathway Diagram
 MyD88 Cascade Initiated On Plasma Membrane Pathway antibodies  MyD88 Cascade Initiated On Plasma Membrane Pathway Diagram
 MyD88 Dependent Cascade Initiated On Endosome Pathway antibodies  MyD88 Dependent Cascade Initiated On Endosome Pathway Diagram
 MyD88:Mal Cascade Initiated On Plasma Membrane Pathway antibodies  MyD88:Mal Cascade Initiated On Plasma Membrane Pathway Diagram
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1 publications with PELI2 and Necrosis
Organs/Tissues associated with PELI2 blocking peptide
 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >2 publications with PELI2 and Bone Marrow
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