Q8NEB9.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
101,549 Da
NCBI Official Full Name
Phosphatidylinositol 3-kinase catalytic subunit type 3
NCBI Official Synonym Full Names
phosphatidylinositol 3-kinase catalytic subunit type 3
NCBI Protein Information
phosphatidylinositol 3-kinase catalytic subunit type 3
UniProt Protein Name
Phosphatidylinositol 3-kinase catalytic subunit type 3
UniProt Synonym Protein Names
Phosphatidylinositol 3-kinase p100 subunit; Phosphoinositide-3-kinase class 3; hVps34
UniProt Synonym Gene Names
VPS34; PI3-kinase type 3; PI3K type 3; PtdIns-3-kinase type 3 [Similar Products]
UniProt Entry Name
PK3C3_HUMAN
UniProt Comments for PIK3C3
PIK3C3: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes. Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4. Forms a complex with BECN1, PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. In this complex, presence of UVRAG and ATG14 are mutually exclusive. Part of a complex composed of PIK3R4 and PIK3CB. Interacts with RAB7A in the presence of PIK3R4. Ubiquitously expressed, with a highest expression in skeletal muscle. Belongs to the PI3/PI4-kinase family.
Protein type: Motility/polarity/chemotaxis; Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.137; Kinase, lipid
Chromosomal Location of Human Ortholog: 18q12.3
Cellular Component: axoneme; cytosol; late endosome; membrane; midbody; phagocytic vesicle membrane; phosphoinositide 3-kinase complex
Molecular Function: 1-phosphatidylinositol-3-kinase activity; protein binding
Biological Process: cellular response to glucose starvation; cytokinesis; early endosome to late endosome transport; macroautophagy; phosphatidylinositol biosynthetic process; regulation of cytokinesis; toll-like receptor 9 signaling pathway
Research Articles on PIK3C3
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Products associated with PIK3C3 blocking peptide
Pathways associated with PIK3C3 blocking peptide
Diseases associated with PIK3C3 blocking peptide
Organs/Tissues associated with PIK3C3 blocking peptide
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