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PKLR blocking peptide

Scan QR to view Datasheet Catalog #    MBS9226527 PKLR blocking peptide
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PKLR, Blocking Peptide

 Also Known As   

PKLR Antibody (C-term) Blocking Peptide

 Product Synonym Names    Pyruvate kinase PKLR; Pyruvate kinase 1; Pyruvate kinase isozymes L/R; R-type/L-type pyruvate kinase; Red cell/liver pyruvate kinase; PKLR; PK1; PKL
 Product Gene Name   

PKLR blocking peptide

[Similar Products]
 Product Synonym Gene Name    PK1; PKL [Similar Products]
 Antibody/Peptide Pairs    PKLR peptide (MBS9226527) is used for blocking the activity of PKLR antibody (MBS9213690)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    102900
 3D Structure    ModBase 3D Structure for P30613
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 Specificity    The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human PKLR. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
 Form/Format    The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of PKLR blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PKLR blocking peptide

   Plays a key role in glycolysis.
NCBI/Uniprot data below describe general gene information for PKLR. It may not necessarily be applicable to this product.
 NCBI GI #    8247933
 NCBI GeneID    5313
 NCBI Accession #    P30613.2 [Other Products]
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 UniProt Primary Accession #    P30613 [Other Products]
 UniProt Secondary Accession #    O75758; P11973 [Other Products]
 UniProt Related Accession #    P30613 [Other Products]
 Molecular Weight    58,494 Da
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 NCBI Official Full Name    Pyruvate kinase PKLR
 NCBI Official Synonym Full Names    pyruvate kinase, liver and RBC
 NCBI Official Symbol    PKLR [Similar Products]
 NCBI Official Synonym Symbols   
PK1; PKL; PKR; RPK; PKRL
[Similar Products]
 NCBI Protein Information    pyruvate kinase PKLR
 UniProt Protein Name    Pyruvate kinase PKLR
 UniProt Synonym Protein Names   
Pyruvate kinase 1; Pyruvate kinase isozymes L/R; R-type/L-type pyruvate kinase; Red cell/liver pyruvate kinase
 Protein Family    Pyruvate kinase
 UniProt Gene Name    PKLR [Similar Products]
 UniProt Synonym Gene Names    PK1; PKL [Similar Products]
 UniProt Entry Name    KPYR_HUMAN
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 NCBI Summary for PKLR    The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PKLR    PKLR: one of three rate-limiting enzymes in glycolysis. It catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to ADP, yielding one molecule ATP and a pyruvate molecule, which is a central metabolic intermediate that can be used as a building block or oxidized further. There are several mammalian isozymes of pyruvate kinase encoded by different genes. The L type predominates in liver, and the M type in muscle and brain. Two alternatively spliced human isoforms have been described: the R- and L-types.

Protein type: Nucleotide Metabolism - purine; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; Kinase, other; EC 2.7.1.40

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: cytosol

Molecular Function: pyruvate kinase activity

Disease: Adenosine Triphosphate, Elevated, Of Erythrocytes; Pyruvate Kinase Deficiency Of Red Cells
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 Research Articles on PKLR    1. PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PKLR blocking peptideDiseases associated with PKLR blocking peptide
 Products by Pathway  Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 ChREBP Activates Metabolic Gene Expression Pathway antibodies  ChREBP Activates Metabolic Gene Expression Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Glucose Metabolism Pathway antibodies  Glucose Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Anemia Antibodies  >50 publications with PKLR and Anemia
 Pyruvate Kinase Deficiency of Red Cells Antibodies  >11 publications with PKLR and Pyruvate Kinase Deficiency of Red Cells
 Liver Diseases Antibodies  >10 publications with PKLR and Liver Diseases
 Fatty Liver Antibodies  >8 publications with PKLR and Fatty Liver
 Inflammation Antibodies  >7 publications with PKLR and Inflammation
 Jaundice Antibodies  >4 publications with PKLR and Jaundice
 Liver Neoplasms Antibodies  >3 publications with PKLR and Liver Neoplasms
 Necrosis Antibodies  >2 publications with PKLR and Necrosis
 Hypertrophy Antibodies  >2 publications with PKLR and Hypertrophy
 Weight Loss Antibodies  >1 publications with PKLR and Weight Loss
Organs/Tissues associated with PKLR blocking peptide
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >37 publications with PKLR and Liver
 Kidney Antibodies  >3 publications with PKLR and Kidney
 Skin Antibodies  >1 publications with PKLR and Skin
 Lung Antibodies  >1 publications with PKLR and Lung
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