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UIMC1 blocking peptide :: RAP80 Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS152851 UIMC1 blocking peptide
Unit / Price
0.05 mg  /  $135 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RAP80 (UIMC1), Blocking Peptide

 Also Known As   

RAP80 Peptide

 Product Synonym Names    RAP80; X2HRIP110; RAP80; RXRIP110; BRCA1-A complex subunit RAP80; Receptor-associated protein 80; ubiquitin interaction motif containing 1
 Product Gene Name   

UIMC1 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    RAP80 peptide (MBS152851) is used for blocking the activity of RAP80 antibody (MBS150198)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Western Blot Protocol    Western Blot Peptide Blocking Protocol
 OMIM    609433
 3D Structure    ModBase 3D Structure for Q96RL1
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 Form/Format    Liquid
 Concentration    200 ug/mL (lot specific)
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 Species    Human
 Buffer    PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
 Location    17 amino acids near the carboxy terminus of human RAP80.
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 Preparation and Storage    Store RAP80 peptide at -20 degree C, stable for one year.
 Other Notes    Small volumes of UIMC1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for UIMC1 blocking peptide   

Blocking (BL)

 Application Notes for UIMC1 blocking peptide    RAP80 peptide is used for blocking the activity of RAP80 antibody.
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NCBI/Uniprot data below describe general gene information for UIMC1. It may not necessarily be applicable to this product.
 NCBI GI #    119605449
 NCBI GeneID    51720
 NCBI Accession #    EAW85043 [Other Products]
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 UniProt Primary Accession #    Q96RL1 [Other Products]
 UniProt Secondary Accession #    Q5XKQ1; Q7Z3W7; Q8N5B9; Q9BZR1; Q9BZR5; Q9UHX7; A8MSA1; B3KMZ1; B4E3N2 [Other Products]
 UniProt Related Accession #    Q96RL1 [Other Products]
 Molecular Weight    17,412 Da
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 NCBI Official Full Name    receptor associated protein 80, isoform CRA_c
 NCBI Official Synonym Full Names    ubiquitin interaction motif containing 1
 NCBI Official Symbol    UIMC1 [Similar Products]
 NCBI Official Synonym Symbols   
RAP80; X2HRIP110
[Similar Products]
 NCBI Protein Information    BRCA1-A complex subunit RAP80; receptor associated protein 80; receptor-associated protein 80; retinoid x receptor interacting protein; retinoid X receptor-interacting protein 110; ubiquitin interaction motif-containing protein 1
 UniProt Protein Name    BRCA1-A complex subunit RAP80
 UniProt Synonym Protein Names   
Receptor-associated protein 80; Retinoid X receptor-interacting protein 110; Ubiquitin interaction motif-containing protein 1
 Protein Family    BRCA1-A complex
 UniProt Gene Name    UIMC1 [Similar Products]
 UniProt Synonym Gene Names    RAP80; RXRIP110 [Similar Products]
 UniProt Entry Name    UIMC1_HUMAN
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 UniProt Comments for UIMC1    RAP80: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly Act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. Interacts with TSP57. Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with FAM175A/Abraxas. Interacts with ESR1, NR6A1 and UBE2I. Expressed in testis, ovary, thymus and heart. Expressed in germ cells of the testis. Belongs to the RAP80 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 5q35.2

Cellular Component: nucleus

Molecular Function: retinoid X receptor binding; protein binding; histone binding

Biological Process: positive regulation of DNA repair; transcription, DNA-dependent; double-strand break repair; response to ionizing radiation; G2/M transition DNA damage checkpoint; negative regulation of transcription, DNA-dependent
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 Research Articles on UIMC1    1. Data indicate that a single point deletion (DeltaE81) in RAP80 abrogates multivalent interactions with polyubiquitin.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with UIMC1 blocking peptideOrgans/Tissues associated with UIMC1 blocking peptide
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >1 publications with UIMC1 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1 publications with UIMC1 and Blood
 Testis Antibodies  >1 publications with UIMC1 and Testis
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