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RYK blocking peptide

Scan QR to view Datasheet Catalog #    MBS9227156 RYK blocking peptide
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RYK, Blocking Peptide

 Also Known As   

RYK Antibody Blocking Peptide

 Product Synonym Names    Tyrosine-protein kinase RYK; RYK; JTK5A
 Product Gene Name   

RYK blocking peptide

[Similar Products]
 Product Synonym Gene Name    JTK5A [Similar Products]
 Antibody/Peptide Pairs    RYK peptide (MBS9227156) is used for blocking the activity of RYK antibody (MBS9212723)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600524
 3D Structure    ModBase 3D Structure for P34925
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 Specificity    The synthetic peptide sequence is selected from aa 175~191 of human RYK.
 Form/Format    The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
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 Cellular Location    Membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm. Note: In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus.
 Tissue Location    Observed in all the tissues examined.
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of RYK blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for RYK blocking peptide

   May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C- terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.
NCBI/Uniprot data below describe general gene information for RYK. It may not necessarily be applicable to this product.
 NCBI GI #    1710811
 NCBI GeneID    6259
 NCBI Accession #    P34925.2 [Other Products]
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 UniProt Primary Accession #    P34925 [Other Products]
 UniProt Secondary Accession #    Q04696 [Other Products]
 UniProt Related Accession #    P34925 [Other Products]
 Molecular Weight    67,764 Da
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 NCBI Official Full Name    Tyrosine-protein kinase RYK
 NCBI Official Synonym Full Names    receptor-like tyrosine kinase
 NCBI Official Symbol    RYK [Similar Products]
 NCBI Official Synonym Symbols   
JTK5; RYK1; JTK5A; D3S3195
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase RYK
 UniProt Protein Name    Tyrosine-protein kinase RYK
 Protein Family    Tyrosine-protein kinase
 UniProt Gene Name    RYK [Similar Products]
 UniProt Synonym Gene Names    JTK5A [Similar Products]
 UniProt Entry Name    RYK_HUMAN
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 NCBI Summary for RYK    The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]
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 UniProt Comments for RYK    RYK: a receptor tyrosine kinase of the Ryk family. Associates with, and may modulate the signaling of, EphB2 and EphB3. Expressed in nestin-positive progenitor cells and neurons, some oligodendrocytes, O-2A progenitor cells, and type-2 astrocytes in developing CNS.

Protein type: EC 2.7.10.1; Protein kinase, TK; Kinase, protein; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; Ryk family

Chromosomal Location of Human Ortholog: 3q22

Cellular Component: cytoplasm; integral to plasma membrane; membrane; nucleus; plasma membrane

Molecular Function: frizzled binding; protein binding; protein-tyrosine kinase activity; transmembrane receptor activity; transmembrane receptor protein tyrosine kinase activity; Wnt receptor activity; Wnt-protein binding

Biological Process: axon guidance; axonogenesis; cell proliferation in midbrain; corpus callosum development; neurite development; neuron differentiation; positive regulation of MAPKKK cascade; protein amino acid phosphorylation; signal transduction; Wnt receptor signaling pathway
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 Research Articles on RYK    1. Early treatment with HGF/IgG complexes after myocardial ischaemia with reperfusion may rescue tissue through vasoprotection conferred by c-Met and RYK signalling
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with RYK blocking peptideDiseases associated with RYK blocking peptide
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Beta-catenin Independent WNT Signaling Pathway antibodies  Beta-catenin Independent WNT Signaling Pathway Diagram
 PCP/CE Pathway antibodies  PCP/CE Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Wnt Pathway antibodies  Signaling By Wnt Pathway Diagram
 TCF Dependent Signaling In Response To WNT Pathway antibodies  TCF Dependent Signaling In Response To WNT Pathway Diagram
 Wnt Signaling Network Pathway antibodies  Wnt Signaling Network Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >20 publications with RYK and Nervous System Diseases
 Kidney Diseases Antibodies  >6 publications with RYK and Kidney Diseases
 Adenocarcinoma Antibodies  >6 publications with RYK and Adenocarcinoma
 Disease Models, Animal Antibodies  >6 publications with RYK and Disease Models, Animal
 Glioblastoma Antibodies  >5 publications with RYK and Glioblastoma
 Inflammation Antibodies  >5 publications with RYK and Inflammation
 Breast Neoplasms Antibodies  >4 publications with RYK and Breast Neoplasms
 Craniofacial Abnormalities Antibodies  >4 publications with RYK and Craniofacial Abnormalities
 Proteinuria Antibodies  >3 publications with RYK and Proteinuria
 Carcinoma, Hepatocellular Antibodies  >3 publications with RYK and Carcinoma, Hepatocellular
Organs/Tissues associated with RYK blocking peptide
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >40 publications with RYK and Brain
 Blood Antibodies  >38 publications with RYK and Blood
 Embryonic Tissue Antibodies  >29 publications with RYK and Embryonic Tissue
 Nerve Antibodies  >21 publications with RYK and Nerve
 Lung Antibodies  >18 publications with RYK and Lung
 Heart Antibodies  >18 publications with RYK and Heart
 Vascular Antibodies  >17 publications with RYK and Vascular
 Bone Antibodies  >16 publications with RYK and Bone
 Bladder Antibodies  >13 publications with RYK and Bladder
 Kidney Antibodies  >10 publications with RYK and Kidney
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