AAH10492
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
112,149 Da
NCBI Official Full Name
signal-induced proliferation-associated protein 1
NCBI Official Synonym Full Names
signal-induced proliferation-associated 1
NCBI Official Synonym Symbols
NCBI Protein Information
signal-induced proliferation-associated protein 1; sipa-1; p130 SPA-1; GTPase-activating protein Spa-1; signal-induced proliferation-associated gene 1
UniProt Protein Name
Signal-induced proliferation-associated protein 1
UniProt Synonym Protein Names
GTPase-activating protein Spa-1; p130 SPA-1
UniProt Synonym Gene Names
UniProt Entry Name
SIPA1_HUMAN
NCBI Summary for SIPA1
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]
UniProt Comments for SIPA1
SIPA1: GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state.
Protein type: GAPs; GAPs, Ras
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: Golgi apparatus; transport vesicle; protein complex; perinuclear region of cytoplasm; nucleolus; plasma membrane; cytosol; nucleus
Molecular Function: protein C-terminus binding; protein binding; GTPase activator activity
Biological Process: cell proliferation; cellular response to water deprivation; cytoskeleton organization and biogenesis; negative regulation of cell adhesion; negative regulation of cell growth; signal transduction; negative regulation of cell cycle; positive regulation of GTPase activity
Research Articles on SIPA1
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Products associated with SIPA1 blocking peptide
Pathways associated with SIPA1 blocking peptide
Diseases associated with SIPA1 blocking peptide
Organs/Tissues associated with SIPA1 blocking peptide
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