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SNAI2 blocking peptide :: Slug Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS153101 SNAI2 blocking peptide
Unit / Price
0.05 mg  /  $135 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Slug (SNAI2), Blocking Peptide

 Also Known As   

Slug Peptide

 Product Synonym Names    SLUG; WS2D; SLUGH1; SNAIL2; SLUG; SLUGH; Zinc finger protein SNAI2; Neural crest transcription factor Slug; snail homolog 2 (Drosophila)
 Product Gene Name   

SNAI2 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    Slug peptide (MBS153101) is used for blocking the activity of Slug antibody (MBS150130)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Western Blot Protocol    Western Blot Peptide Blocking Protocol
 OMIM    gene 608890
 3D Structure    ModBase 3D Structure for O43623
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 Form/Format    Liquid
 Concentration    200 ug/mL (lot specific)
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 Species    Human
 Buffer    PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
 Location    13 amino acids near the center of human Slug..
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 Preparation and Storage    Store Slug peptide at -20 degree C, stable for one year.
 Other Notes    Small volumes of SNAI2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for SNAI2 blocking peptide   

Blocking (BL)

 Application Notes for SNAI2 blocking peptide    Slug peptide is used for blocking activity of Slug antibody.
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NCBI/Uniprot data below describe general gene information for SNAI2. It may not necessarily be applicable to this product.
 NCBI GI #    11134406
 NCBI GeneID    6591
 NCBI Accession #    O43623.1 [Other Products]
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 UniProt Primary Accession #    O43623 [Other Products]
 UniProt Secondary Accession #    Q53FC1; B2R6P6 [Other Products]
 UniProt Related Accession #    O43623 [Other Products]
 Molecular Weight    29,986 Da
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 NCBI Official Full Name    Zinc finger protein SNAI2
 NCBI Official Synonym Full Names    snail family zinc finger 2
 NCBI Official Symbol    SNAI2 [Similar Products]
 NCBI Official Synonym Symbols   
SLUG; WS2D; SLUGH1; SNAIL2
[Similar Products]
 NCBI Protein Information    zinc finger protein SNAI2; snail homolog 2; protein snail homolog 2; neural crest transcription factor SLUG; slug (chicken homolog), zinc finger protein
 UniProt Protein Name    Zinc finger protein SNAI2
 UniProt Synonym Protein Names   
Neural crest transcription factor Slug; Protein snail homolog 2
 Protein Family    Zinc finger protein
 UniProt Gene Name    SNAI2 [Similar Products]
 UniProt Synonym Gene Names    SLUG; SLUGH [Similar Products]
 UniProt Entry Name    SNAI2_HUMAN
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 NCBI Summary for SNAI2    This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SNAI2    Snail2: Transcriptional repressor. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains). Expressed in placenta and adult heart, pancreas, liver, kidney and skeletal muscle. Belongs to the snail C2H2-type zinc-finger protein family.

Protein type: Apoptosis; Motility/polarity/chemotaxis; C2H2-type zinc finger protein; Transcription factor

Chromosomal Location of Human Ortholog: 8q11

Cellular Component: cytoplasm; nuclear chromatin; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; metal ion binding; chromatin binding

Biological Process: transcription from RNA polymerase II promoter; Notch signaling pathway; substrate-bound cell migration, cell release from substrate; regulation of osteoblast differentiation; neural crest cell development; negative regulation of chondrocyte differentiation; Wnt receptor signaling pathway through beta-catenin; negative regulation of transcription from RNA polymerase II promoter; palate development; osteoblast differentiation; negative regulation of DNA damage response, signal transduction by p53 class mediator; sensory perception of sound; pigmentation; white fat cell differentiation; epithelial to mesenchymal transition; positive regulation of fat cell differentiation; positive regulation of histone acetylation; negative regulation of cell adhesion mediated by integrin; regulation of chemokine production; positive regulation of cell migration

Disease: Waardenburg Syndrome, Type 2d; Piebald Trait
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 Research Articles on SNAI2    1. High expression of slug was correlated with salivary adenoid cystic cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SNAI2 blocking peptidePathways associated with SNAI2 blocking peptide
 Reference Product  PubMed Publications
 KITLG blocking peptide  >20 publications with SNAI2 and KITLG
 CDH1 blocking peptide  >19 publications with SNAI2 and CDH1
 CTNNB1 blocking peptide  >14 publications with SNAI2 and CTNNB1
 KIT blocking peptide  >7 publications with SNAI2 and KIT
 FN1 blocking peptide  >5 publications with SNAI2 and FN1
 TP53 blocking peptide  >3 publications with SNAI2 and TP53
 BBC3 blocking peptide  >3 publications with SNAI2 and BBC3
 MAPK3 blocking peptide  >2 publications with SNAI2 and MAPK3
 MMP14 blocking peptide  >1 publications with SNAI2 and MMP14
 LEF1 blocking peptide  >1 publications with SNAI2 and LEF1
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies  Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
 Signaling Events Mediated By Stem Cell Factor Receptor (c-Kit) Pathway antibodies  Signaling Events Mediated By Stem Cell Factor Receptor (c-Kit) Pathway Diagram
Diseases associated with SNAI2 blocking peptideOrgans/Tissues associated with SNAI2 blocking peptide
 Disease Name  Pubmed Publications
 Neoplasm Invasiveness Antibodies  >27 publications with SNAI2 and Neoplasm Invasiveness
 Neoplasm Metastasis Antibodies  >25 publications with SNAI2 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >21 publications with SNAI2 and Breast Neoplasms
 Lung Neoplasms Antibodies  >14 publications with SNAI2 and Lung Neoplasms
 Carcinoma, Squamous Cell Antibodies  >10 publications with SNAI2 and Carcinoma, Squamous Cell
 Cell Transformation, Neoplastic Antibodies  >10 publications with SNAI2 and Cell Transformation, Neoplastic
 Lung Diseases Antibodies  >9 publications with SNAI2 and Lung Diseases
 Nervous System Diseases Antibodies  >9 publications with SNAI2 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >9 publications with SNAI2 and Neoplasms, Experimental
 Prostatic Neoplasms Antibodies  >6 publications with SNAI2 and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >20 publications with SNAI2 and Lung
 Skin Antibodies  >18 publications with SNAI2 and Skin
 Embryonic Tissue Antibodies  >13 publications with SNAI2 and Embryonic Tissue
 Bone Antibodies  >12 publications with SNAI2 and Bone
 Prostate Antibodies  >11 publications with SNAI2 and Prostate
 Muscle Antibodies  >11 publications with SNAI2 and Muscle
 Brain Antibodies  >10 publications with SNAI2 and Brain
 Liver Antibodies  >7 publications with SNAI2 and Liver
 Kidney Antibodies  >5 publications with SNAI2 and Kidney
 Heart Antibodies  >5 publications with SNAI2 and Heart
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