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TET3 blocking peptide

Scan QR to view Datasheet Catalog #    MBS152112
Western Blot (WB)
Unit / Price
0.05 mg  /  $140 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TET3, Blocking Peptide

★Popular Item★
 Also Known As   

TET3 Peptide

 Product Synonym Names    hCG_40738; KIAA0401; Methylcytosine dioxygenase TET3; TET methylcytosine dioxygenase 3
 Product Gene Name   

TET3 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    TET3 peptide (MBS152112) is used for blocking the activity of TET3 antibody (MBS151041)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Western Blot Protocol    Western Blot Peptide Blocking Protocol
 OMIM    613555
 3D Structure    ModBase 3D Structure for O43151
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 Form/Format    Liquid
 Concentration    200 ug/mL (lot specific)
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 Species    Human
 Buffer    PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
 Location    17 amino acid peptide near the carboxy terminus of human TET3.
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 Preparation and Storage    Store TET3 peptide at -20 degree C, stable for one year.
 Other Notes    Small volumes of TET3 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for TET3 blocking peptide   

Blocking (BL)

 Application Notes for TET3 blocking peptide    TET3 peptide is used for blocking the activity of TET3 antibody.
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 Western Blot (WB) of TET3 blocking peptide    Western blot analysis of TET3 in SK-N-SH cell lysate with TET3 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
TET3 blocking peptide Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TET3. It may not necessarily be applicable to this product.
 NCBI GI #    149944516
 NCBI GeneID    200424
 NCBI Accession #    NP_659430 [Other Products]
 NCBI GenBank Nucleotide #    NM_144993.1 [Other Products]
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 UniProt Primary Accession #    O43151 [Other Products]
 UniProt Secondary Accession #    Q86Z24; Q8TBM9; A6NEI3 [Other Products]
 UniProt Related Accession #    O43151 [Other Products]
 Molecular Weight    77,471 Da
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 NCBI Official Synonym Full Names    tet methylcytosine dioxygenase 3
 NCBI Official Symbol    TET3 [Similar Products]
 NCBI Official Synonym Symbols   
hCG_40738
[Similar Products]
 NCBI Protein Information    methylcytosine dioxygenase TET3
 UniProt Protein Name    Methylcytosine dioxygenase TET3
 Protein Family    Tetraspanin
 UniProt Gene Name    TET3 [Similar Products]
 UniProt Synonym Gene Names    KIAA0401 [Similar Products]
 UniProt Entry Name    TET3_HUMAN
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 NCBI Summary for TET3    Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009 [PubMed 19923888]).[supplied by OMIM, Nov 2010]
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 UniProt Comments for TET3    TET3: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Conversion into 5hmC initiates a process leading to cytosine demethylation through deamination into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin. Belongs to the TET family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.11.n2; Oxidoreductase

Chromosomal Location of Human Ortholog: 2p13.1

Cellular Component: male pronucleus; cytoplasm; female pronucleus

Molecular Function: protein binding; DNA binding; metal ion binding

Biological Process: protein amino acid O-linked glycosylation; gene expression; positive regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic
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 Research Articles on TET3    1. In hepatic stellate cells, cell proliferation rise significantly and cell apoptosis reduce obviously after knockdown of TET3.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TET3 blocking peptidePathways associated with TET3 blocking peptide
 Reference Product  PubMed Publications
 NANOG blocking peptide  >5 publications with TET3 and NANOG
 Products by Pathway  Pathway Diagram
 Epigenetic Regulation Of Gene Expression Pathway antibodies  Epigenetic Regulation Of Gene Expression Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 TET1,2,3 And TDG Demethylate DNA Pathway antibodies  TET1,2,3 And TDG Demethylate DNA Pathway Diagram
Diseases associated with TET3 blocking peptideOrgans/Tissues associated with TET3 blocking peptide
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >2 publications with TET3 and Kidney Diseases
 Adenocarcinoma Antibodies  >1 publications with TET3 and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >1 publications with TET3 and Cell Transformation, Neoplastic
 Adenoma Antibodies  >1 publications with TET3 and Adenoma
 Necrosis Antibodies  >1 publications with TET3 and Necrosis
 Intestinal Neoplasms Antibodies  >1 publications with TET3 and Intestinal Neoplasms
 Death Antibodies  >1 publications with TET3 and Death
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >17 publications with TET3 and Brain
 Embryonic Tissue Antibodies  >7 publications with TET3 and Embryonic Tissue
 Bone Antibodies  >5 publications with TET3 and Bone
 Liver Antibodies  >5 publications with TET3 and Liver
 Blood Antibodies  >4 publications with TET3 and Blood
 Prostate Antibodies  >2 publications with TET3 and Prostate
 Lung Antibodies  >2 publications with TET3 and Lung
 Pancreas Antibodies  >1 publications with TET3 and Pancreas
 Eye Antibodies  >1 publications with TET3 and Eye
 Testis Antibodies  >1 publications with TET3 and Testis
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