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TPPP blocking peptide

Scan QR to view Datasheet Catalog #    MBS9222252 TPPP blocking peptide
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TPPP, Blocking Peptide

 Also Known As   

TPPP Antibody (Center) Blocking Peptide

 Product Synonym Names    Tubulin polymerization-promoting protein; TPPP; 25 kDa brain-specific protein; TPPP/p25; p24; p25-alpha; TPPP; TPPP1
 Product Gene Name   

TPPP blocking peptide

[Similar Products]
 Product Synonym Gene Name    TPPP1 [Similar Products]
 Antibody/Peptide Pairs    TPPP peptide (MBS9222252) is used for blocking the activity of TPPP antibody (MBS9206617)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608773
 3D Structure    ModBase 3D Structure for O94811
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 Form/Format    Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
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 Cellular Location    Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note: Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies
 Tissue Location    Widely expressed.
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of TPPP blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for TPPP blocking peptide

   May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.
NCBI/Uniprot data below describe general gene information for TPPP. It may not necessarily be applicable to this product.
 NCBI GI #    28380097
 NCBI GeneID    11076
 NCBI Accession #    O94811.1 [Other Products]
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 UniProt Primary Accession #    O94811 [Other Products]
 UniProt Related Accession #    O94811 [Other Products]
 Molecular Weight    23,694 Da
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 NCBI Official Full Name    Tubulin polymerization-promoting protein
 NCBI Official Synonym Full Names    tubulin polymerization promoting protein
 NCBI Official Symbol    TPPP [Similar Products]
 NCBI Official Synonym Symbols   
p24; p25; TPPP1; TPPP/p25; p25alpha
[Similar Products]
 NCBI Protein Information    tubulin polymerization-promoting protein
 UniProt Protein Name    Tubulin polymerization-promoting protein
 UniProt Synonym Protein Names   
25 kDa brain-specific protein; TPPP/p25; p24; p25-alpha
 Protein Family    TPPP family protein
 UniProt Gene Name    TPPP [Similar Products]
 UniProt Synonym Gene Names    TPPP1; TPPP [Similar Products]
 UniProt Entry Name    TPPP_HUMAN
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 UniProt Comments for TPPP    TPPP: May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown. Belongs to the TPPP family.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 5p15.3

Cellular Component: cytoplasm; microtubule; nucleus; perinuclear region of cytoplasm

Molecular Function: microtubule binding; protein binding; tubulin binding

Biological Process: microtubule bundle formation; microtubule polymerization; positive regulation of protein complex assembly; positive regulation of protein polymerization
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 Research Articles on TPPP    1. Results reveal a link between p25 and BACE1 in Alzheimer disease (AD) brains and suggest that upregulated Cdk5 activation by p25 accelerates AD pathogenesis by enhancing BACE1 activity via phosphorylation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TPPP blocking peptidePathways associated with TPPP blocking peptide
 Reference Product  PubMed Publications
 SNCA blocking peptide  >4 publications with TPPP and SNCA
 LIMK1 blocking peptide  >2 publications with TPPP and LIMK1
 GAPDH blocking peptide  >1 publications with TPPP and GAPDH
 ROCK1 blocking peptide  >1 publications with TPPP and ROCK1
 Products by Pathway  Pathway Diagram
 Glial Cell Differentiation Pathway antibodies  Glial Cell Differentiation Pathway Diagram
 Regulation Of Microtubule Cytoskeleton Pathway antibodies  Regulation Of Microtubule Cytoskeleton Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
Diseases associated with TPPP blocking peptideOrgans/Tissues associated with TPPP blocking peptide
 Disease Name  Pubmed Publications
 Atrophy Antibodies  >11 publications with TPPP and Atrophy
 Nerve Degeneration Antibodies  >8 publications with TPPP and Nerve Degeneration
 Mental Disorders Antibodies  >3 publications with TPPP and Mental Disorders
 Nervous System Malformations Antibodies  >2 publications with TPPP and Nervous System Malformations
 Neurobehavioral Manifestations Antibodies  >2 publications with TPPP and Neurobehavioral Manifestations
 Memory Disorders Antibodies  >1 publications with TPPP and Memory Disorders
 Neoplasm Metastasis Antibodies  >1 publications with TPPP and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >1 publications with TPPP and Neoplasms, Experimental
 Necrosis Antibodies  >1 publications with TPPP and Necrosis
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with TPPP and Prenatal Exposure Delayed Effects
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >47 publications with TPPP and Nerve
 Brain Antibodies  >41 publications with TPPP and Brain
 Blood Antibodies  >2 publications with TPPP and Blood
 Lung Antibodies  >2 publications with TPPP and Lung
 Pancreas Antibodies  >1 publications with TPPP and Pancreas
 Skin Antibodies  >1 publications with TPPP and Skin
 Kidney Antibodies  >1 publications with TPPP and Kidney
 Intestine Antibodies  >1 publications with TPPP and Intestine
 Ovary Antibodies  >1 publications with TPPP and Ovary
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