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TRAF2 blocking peptide

Scan QR to view Datasheet Catalog #    MBS153259 TRAF2 blocking peptide
Unit / Price
0.05 mg  /  $135 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TRAF2, Blocking Peptide

 Also Known As   

TRAF2 Peptide

 Product Synonym Names    TRAP; TRAP3; MGC:45012; TNF receptor-associated factor 2; E3 ubiquitin-protein ligase TRAF2; TNF receptor-associated factor 2
 Product Gene Name   

TRAF2 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    TRAF2 peptide (MBS153259) is used for blocking the activity of TRAF2 antibody (MBS150982)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Western Blot Protocol    Western Blot Peptide Blocking Protocol
 OMIM    601895
 3D Structure    ModBase 3D Structure for Q12933
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 Form/Format    Liquid
 Concentration    200 ug/mL (lot specific)
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 Species    Human
 Buffer    PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
 Location    17 amino acids near the carboxy terminus of human TRAF2.
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 Preparation and Storage    Store TRAF2 peptide at -20 degree C, stable for one year.
 Other Notes    Small volumes of TRAF2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for TRAF2 blocking peptide   

Blocking (BL)

 Application Notes for TRAF2 blocking peptide    TRAF2 peptide is used for blocking the activity of TRAF2 antibody.
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NCBI/Uniprot data below describe general gene information for TRAF2. It may not necessarily be applicable to this product.
 NCBI GI #    55959980
 NCBI GeneID    7186
 NCBI Accession #    CAI15106 [Other Products]
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 UniProt Primary Accession #    Q12933 [Other Products]
 UniProt Secondary Accession #    Q7Z337; Q96NT2; A8K107; B4DPJ7 [Other Products]
 UniProt Related Accession #    Q12933 [Other Products]
 Molecular Weight    53,055 Da
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 NCBI Official Synonym Full Names    TNF receptor-associated factor 2
 NCBI Official Symbol    TRAF2 [Similar Products]
 NCBI Official Synonym Symbols   
TRAP; TRAP3; MGC:45012
[Similar Products]
 NCBI Protein Information    TNF receptor-associated factor 2
 UniProt Protein Name    TNF receptor-associated factor 2
 UniProt Synonym Protein Names   
E3 ubiquitin-protein ligase TRAF2; Tumor necrosis factor type 2 receptor-associated protein 3
 Protein Family    TNF receptor-associated factor
 UniProt Gene Name    TRAF2 [Similar Products]
 UniProt Synonym Gene Names    TRAP3 [Similar Products]
 UniProt Entry Name    TRAF2_HUMAN
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 NCBI Summary for TRAF2    The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TRAF2    TRAF2: Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'- linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin- protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Homotrimer, and heterotrimer with TRAF1 and TRAF3 (via TRAF domain). The domain containing the RING-type and the first TRAF-type zinc finger can also form homodimers (in vitro). Interacts with TNFRSF1B/TNFR2, TNFRSF4, TNFRSF5/CD40, CD27/TNFRSF7, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF16/NGFR, TNFRSF17/BCMA, TNFRSF18/AITR, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1 and IL15RA. Interacts with CDK9, CSK, MAP3K1, MAP3K5, MAP3K11, MAP3K14, MAP4K2, RIPK1, RIPK2, TNIK, TBK1, SPHK1, TRADD, TRAFD1, TRAIP, TANK/ITRAF, TNFAIP3, TDP2, MAVS/IPS1, TICAM1 and TRPC4AP. Interacts with CASP8AP2, NFATC2IP, PEG3 and HIVEP3. Interacts with BIRC2 and BIRC3 N- terminus; a single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed by TRAF1 and TRAF2, or a TRAF2 homotrimer. Identified in a complex composed of TRAF2, TRAF3, BIRC2 and BIRC3. Interaction with BIRC2 and/or BIRC3 is essential for degradation of NFKBIA and activation of NF-kappa-B. Interacts with CYLD, USP48, DAB2IP, IKKA and IKKB. Identified in a complex with TNFRSF1A, RIPK1 and IKKB. Interacts (via 'Lys-63'-linked polyubiquitin chains) with TAB2 and TAB3. Interacts with ERN1 and TAOK3. Interaction with TAOK3 is facilitated under ER stress conditions, such as treatment with tunicamycin, and may promote TRAF2 phosphorylation. Has very low E3 ubiquitin ligase activity in the absence of sphingosine-1-phosphate. E3 ubiquitin ligase activity is strongly activated by cytoplasmic sphingosine-1- phosphate. Belongs to the TNF receptor-associated factor family. A subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin ligase; Autophagy; Ligase; Ubiquitin conjugating system; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: internal side of plasma membrane; cytoplasm; cell cortex; vesicle membrane; cytosol; ubiquitin ligase complex; lipid raft

Molecular Function: identical protein binding; sphingolipid binding; zinc ion binding; ubiquitin-protein ligase activity; CD40 receptor binding; mitogen-activated protein kinase kinase kinase binding; protein phosphatase binding; tumor necrosis factor receptor binding; protein binding; signal transducer activity; enzyme binding; thioesterase binding; ubiquitin protein ligase binding; protein complex binding; ligase activity

Biological Process: caspase activation; positive regulation of JNK activity; protein autoubiquitination; apoptosis; protein heterooligomerization; activation of NF-kappaB-inducing kinase; positive regulation of T cell cytokine production; signal transduction; activation of NF-kappaB transcription factor; regulation of apoptosis; cellular protein complex assembly; tumor necrosis factor-mediated signaling pathway; positive regulation of interleukin-2 production; innate immune response; positive regulation of transcription factor activity; protein complex assembly; protein catabolic process; positive regulation of T cell activation; regulation of immunoglobulin secretion
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 Research Articles on TRAF2    1. Knockdown of IRE1alpha by siRNA dramatically abrogated CXC195-induced activation of TRAF2, ASK and JNK, formation of an IRE1alpha-TRAF2-ASK1 complex and caspase- and mitochondrial-dependent apoptosis in T24 cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TRAF2 blocking peptidePathways associated with TRAF2 blocking peptide
 Reference Product  PubMed Publications
 TRADD blocking peptide  >213 publications with TRAF2 and TRADD
 CD40 blocking peptide  >175 publications with TRAF2 and CD40
 RIPK1 blocking peptide  >46 publications with TRAF2 and RIPK1
 MAP3K5 blocking peptide  >23 publications with TRAF2 and MAP3K5
 BIRC2 blocking peptide  >22 publications with TRAF2 and BIRC2
 BIRC3 blocking peptide  >21 publications with TRAF2 and BIRC3
 TNFRSF1A blocking peptide  >13 publications with TRAF2 and TNFRSF1A
 TNFRSF1B blocking peptide  >4 publications with TRAF2 and TNFRSF1B
 UBC blocking peptide  >3 publications with TRAF2 and UBC
 Products by Pathway  Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Caspase-8 Activation By Cleavage Pathway antibodies  Caspase-8 Activation By Cleavage Pathway Diagram
 Ceramide Signaling Pathway antibodies  Ceramide Signaling Pathway Diagram
Diseases associated with TRAF2 blocking peptideOrgans/Tissues associated with TRAF2 blocking peptide
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >848 publications with TRAF2 and Necrosis
 Inflammation Antibodies  >167 publications with TRAF2 and Inflammation
 Cardiovascular Diseases Antibodies  >34 publications with TRAF2 and Cardiovascular Diseases
 Liver Diseases Antibodies  >26 publications with TRAF2 and Liver Diseases
 Nervous System Diseases Antibodies  >26 publications with TRAF2 and Nervous System Diseases
 Lung Diseases Antibodies  >21 publications with TRAF2 and Lung Diseases
 Neoplasms, Experimental Antibodies  >20 publications with TRAF2 and Neoplasms, Experimental
 Brain Diseases Antibodies  >20 publications with TRAF2 and Brain Diseases
 Breast Neoplasms Antibodies  >19 publications with TRAF2 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >15 publications with TRAF2 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >224 publications with TRAF2 and Blood
 Vascular Antibodies  >68 publications with TRAF2 and Vascular
 Kidney Antibodies  >49 publications with TRAF2 and Kidney
 Liver Antibodies  >47 publications with TRAF2 and Liver
 Brain Antibodies  >43 publications with TRAF2 and Brain
 Lung Antibodies  >39 publications with TRAF2 and Lung
 Bone Antibodies  >38 publications with TRAF2 and Bone
 Muscle Antibodies  >34 publications with TRAF2 and Muscle
 Heart Antibodies  >32 publications with TRAF2 and Heart
 Spleen Antibodies  >27 publications with TRAF2 and Spleen
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