NP_056989
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
113,018 Da
NCBI Official Full Name
transcription intermediary factor 1-alpha isoform a
NCBI Official Synonym Full Names
tripartite motif containing 24
NCBI Official Synonym Symbols
PTC6; TF1A; TIF1; RNF82; TIF1A; hTIF1; TIF1ALPHA [Similar Products]
NCBI Protein Information
transcription intermediary factor 1-alpha; TIF1-alpha; RING finger protein 82; tripartite motif-containing 24; E3 ubiquitin-protein ligase TRIM24; transcriptional intermediary factor 1
UniProt Protein Name
Transcription intermediary factor 1-alpha
UniProt Synonym Protein Names
E3 ubiquitin-protein ligase TRIM24; RING finger protein 82; Tripartite motif-containing protein 24
UniProt Synonym Gene Names
UniProt Entry Name
TIF1A_HUMAN
NCBI Summary for TRIM24
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for TRIM24
TRIM24: an atypical protein kinase that functions as a transcriptional coactivator. Originally identified as a mammalian protein that enhances the AF-2 activity of the retinoid X receptor (RXR) in a yeast genetic screen. Binds to nuclear receptors in an agonist and AF2-activating domain (AF2-AD) dependent manner. Binding to the agonist-nuclear receptor complex induces its own hyperphosphorylation as well as the phosphorylation of TFIIEa, TAFII28, and TAFII55. Belongs to a family of nuclear proteins that includes TIF1b and TIF1g. TIF1 proteins are characterized by an N-terminal region that contains a RING finger-B boxes-coiled coil (RBCC) motif, a poorly conserved central region, a C-terminal region that contains a PHD finger, and a bromodomain. Interacts with the heterochromatin-associated proteins HP1a, MOD1 (HP1b), and MOD2 (HP1g) and with the transcriptional repression domain KRAB, which is present in many Kruppel-type (C2H2) zinc finger proteins. May act as a repressor through the formation of transcriptionally inactive heterochromatin. Two splice variant isoforms have been described.
Protein type: Ubiquitin conjugating system; Transcription, coactivator/corepressor; Nuclear receptor co-regulator; Protein kinase, atypical; Kinase, protein; EC 6.3.2.-; Tumor suppressor; ATYPICAL group; TIF1 family
Chromosomal Location of Human Ortholog: 7q32-q34
Cellular Component: nucleoplasm; perichromatin fibrils; nucleus; cytosol
Molecular Function: ligand-dependent nuclear receptor binding; protein binding; zinc ion binding; sequence-specific DNA binding; p53 binding; transcription coactivator activity; ubiquitin-protein ligase activity; estrogen response element binding; chromatin binding; methylated histone residue binding; protein kinase activity; receptor binding; ligase activity
Biological Process: transcription from RNA polymerase II promoter; calcium ion homeostasis; regulation of apoptosis; negative regulation of cell proliferation; response to peptide hormone stimulus; protein amino acid autophosphorylation; positive regulation of transcription, DNA-dependent; regulation of protein stability; protein ubiquitination; protein catabolic process; negative regulation of transcription, DNA-dependent
Disease: Thyroid Carcinoma, Papillary
Research Articles on TRIM24
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Products associated with TRIM24 blocking peptide
Pathways associated with TRIM24 blocking peptide
Diseases associated with TRIM24 blocking peptide
Organs/Tissues associated with TRIM24 blocking peptide
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