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TSC2 blocking peptide

Scan QR to view Datasheet Catalog #    MBS152186 TSC2 blocking peptide
Unit / Price
0.05 mg  /  $135 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TSC2, Blocking Peptide

 Also Known As   

TSC2 Peptide

 Product Synonym Names    LAM; TSC4; Tuberin; Tuberous sclerosis 2 protein; tuberous sclerosis 2
 Product Gene Name   

TSC2 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    TSC2 peptide (MBS152186) is used for blocking the activity of TSC2 antibody (MBS151308)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Western Blot Protocol    Western Blot Peptide Blocking Protocol
 OMIM    phenotype 613254
 3D Structure    ModBase 3D Structure for P49815
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 Form/Format    Liquid
 Concentration    200 ug/mL (lot specific)
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 Species    Human
 Buffer    PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
 Location    14 amino acids near the amino terminus of human TSC2.
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 Preparation and Storage    Store TSC2 peptide at -20 degree C, stable for one year.
 Other Notes    Small volumes of TSC2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for TSC2 blocking peptide   

Blocking (BL)

 Application Notes for TSC2 blocking peptide    TSC2 peptide is used for blocking the activity of the TSC2 antibody.
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NCBI/Uniprot data below describe general gene information for TSC2. It may not necessarily be applicable to this product.
 NCBI GI #    116256352
 NCBI GeneID    7249
 NCBI Accession #    NP_000539 [Other Products]
 NCBI GenBank Nucleotide #    NM_000548.3 [Other Products]
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 UniProt Primary Accession #    P49815 [Other Products]
 UniProt Secondary Accession #    O75275; Q4LE71; Q8TAZ1; A7E2E2; B4DIL8; B4DIQ7; B4DRN2; B7Z2B8; C9J378 [Other Products]
 UniProt Related Accession #    P49815 [Other Products]
 Molecular Weight    25,773 Da
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 NCBI Official Full Name    tuberin isoform 1
 NCBI Official Synonym Full Names    tuberous sclerosis 2
 NCBI Official Symbol    TSC2 [Similar Products]
 NCBI Official Synonym Symbols   
LAM; TSC4; PPP1R160
[Similar Products]
 NCBI Protein Information    tuberin; tuberous sclerosis 2 protein; protein phosphatase 1, regulatory subunit 160
 UniProt Protein Name    Tuberin
 UniProt Synonym Protein Names   
Tuberous sclerosis 2 protein
 Protein Family    Tuberin
 UniProt Gene Name    TSC2 [Similar Products]
 UniProt Synonym Gene Names    TSC4 [Similar Products]
 UniProt Entry Name    TSC2_HUMAN
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 NCBI Summary for TSC2    Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TSC2    TSC2: a product of the tumor suppressor gene TSC2. Tuberin and Hamartin (TSC1) form a tumor suppressor heterodimer that inhibits the mTOR nutrient signaling input. TSC1/TSC2 targets the small G protein Rheb, a novel mediator of the nutrient signaling input to mTOR. Functions as a Rheb GTPase activating protein (GAP). Four alternatively spliced isoforms have been described.

Protein type: Nuclear receptor co-regulator; Cell cycle regulation; GAPs, misc.; GAPs; Tumor suppressor

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: TSC1-TSC2 complex; Golgi apparatus; cytoskeleton; growth cone; membrane; cell soma; perinuclear region of cytoplasm; dendrite; cytoplasm; caveola; nucleus; cytosol

Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; GTPase activator activity; phosphatase binding

Biological Process: negative regulation of MAP kinase activity; phosphoinositide 3-kinase cascade; regulation of insulin receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; nerve growth factor receptor signaling pathway; regulation of cell cycle; protein heterooligomerization; heart development; negative regulation of insulin receptor signaling pathway; negative regulation of cell size; negative regulation of cell proliferation; protein localization; cell projection organization and biogenesis; positive chemotaxis; protein import into nucleus; regulation of endocytosis; acute-phase response; protein kinase B signaling cascade; cell cycle arrest; protein homooligomerization; negative regulation of epithelial cell proliferation; epidermal growth factor receptor signaling pathway; negative regulation of TOR signaling pathway; phosphoinositide-mediated signaling; negative regulation of protein kinase B signaling cascade; fibroblast growth factor receptor signaling pathway; endocytosis; vesicle-mediated transport; insulin-like growth factor receptor signaling pathway; glucose import; neural tube closure; response to hypoxia; insulin receptor signaling pathway; negative regulation of protein kinase activity; innate immune response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of phosphoinositide 3-kinase cascade

Disease: Lymphangioleiomyomatosis; Tuberous Sclerosis 2
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 Research Articles on TSC2    1. This work indicates a novel role for this TSC2 gene, which encodes an activator of cell proliferation in response to androgen stimulation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to TSC2 Peptide
 Catalog #  Product Name  Catalog #  Product Name
 MBS9214977  TSC22D2 Antibody (N-term)  MBS9209346  Phospho-TSC2 (S1387) Antibody
 MBS857700  Tsc2 (Phospho-Ser1254) Antibody  MBS7249703  Monkey TSC22 domain family protein 1 (TSC22D1) ELISA Kit
 MBS8512361  Tuberin/TSC2 Antibody  MBS9323109  Rat TSC22 domain family protein 3, TSC22D3 ELISA Kit
 MBS9230798  Phospho-mouse TSC2(S1421) Blocking Peptide  MBS1290678  Recombinant Human Protein TSC21 (TSC21)
 MBS241346  Rabbit Polyclonal to Human Tuberin / TSC2  MBS9221787  TSC22D2 Antibody (N-term) Blocking Peptide
Products associated with TSC2 blocking peptidePathways associated with TSC2 blocking peptide
 Reference Product  PubMed Publications
 TSC1 blocking peptide  >887 publications with TSC2 and TSC1
 MTOR blocking peptide  >637 publications with TSC2 and MTOR
 RHEB blocking peptide  >164 publications with TSC2 and RHEB
 AKT1 blocking peptide  >39 publications with TSC2 and AKT1
 MAPK1 blocking peptide  >11 publications with TSC2 and MAPK1
 RPS6KA1 blocking peptide  >7 publications with TSC2 and RPS6KA1
 YWHAB blocking peptide  >1 publications with TSC2 and YWHAB
 Products by Pathway  Pathway Diagram
 AKT Phosphorylates Targets In The Cytosol Pathway antibodies  AKT Phosphorylates Targets In The Cytosol Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Choline Metabolism In Cancer Pathway antibodies  Choline Metabolism In Cancer Pathway Diagram
 Choline Metabolism In Cancer Pathway antibodies  Choline Metabolism In Cancer Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
Diseases associated with TSC2 blocking peptideOrgans/Tissues associated with TSC2 blocking peptide
 Disease Name  Pubmed Publications
 Tuberous Sclerosis Antibodies  >1313 publications with TSC2 and Tuberous Sclerosis
 Kidney Diseases Antibodies  >209 publications with TSC2 and Kidney Diseases
 Kidney Neoplasms Antibodies  >165 publications with TSC2 and Kidney Neoplasms
 Epilepsy Antibodies  >160 publications with TSC2 and Epilepsy
 Brain Diseases Antibodies  >147 publications with TSC2 and Brain Diseases
 Lymphangioleiomyomatosis Antibodies  >144 publications with TSC2 and Lymphangioleiomyomatosis
 Seizures Antibodies  >112 publications with TSC2 and Seizures
 Tuberous Sclerosis 2 Antibodies  >80 publications with TSC2 and Tuberous Sclerosis 2
 Lung Neoplasms Antibodies  >76 publications with TSC2 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >72 publications with TSC2 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >359 publications with TSC2 and Brain
 Kidney Antibodies  >299 publications with TSC2 and Kidney
 Muscle Antibodies  >166 publications with TSC2 and Muscle
 Lung Antibodies  >154 publications with TSC2 and Lung
 Heart Antibodies  >123 publications with TSC2 and Heart
 Skin Antibodies  >119 publications with TSC2 and Skin
 Blood Antibodies  >106 publications with TSC2 and Blood
 Liver Antibodies  >79 publications with TSC2 and Liver
 Nerve Antibodies  >36 publications with TSC2 and Nerve
 Embryonic Tissue Antibodies  >31 publications with TSC2 and Embryonic Tissue
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