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TUBA4A blocking peptide

Scan QR to view Datasheet Catalog #    MBS9219982 TUBA4A blocking peptide
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TUBA4A, Blocking Peptide

 Also Known As   

TUBA4A Antibody (C-term) Blocking peptide

 Product Synonym Names    Tubulin alpha-4A chain; Alpha-tubulin 1; Testis-specific alpha-tubulin; Tubulin H2-alpha; Tubulin alpha-1 chain; TUBA4A; TUBA1
 Product Gene Name   

TUBA4A blocking peptide

[Similar Products]
 Product Synonym Gene Name    TUBA1 [Similar Products]
 Antibody/Peptide Pairs    TUBA4A peptide (MBS9219982) is used for blocking the activity of TUBA4A antibody (MBS9212231)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    191110
 3D Structure    ModBase 3D Structure for P68366
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 Specificity    The synthetic peptide sequence used to generate the antibody was selected from the C-term region of TUBA4A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
 Form/Format    Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
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 Cellular Location    Cytoplasm, cytoskeleton.
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of TUBA4A blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TUBA4A blocking peptide

   Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
NCBI/Uniprot data below describe general gene information for TUBA4A. It may not necessarily be applicable to this product.
 NCBI GI #    55977476
 NCBI GeneID    7277
 NCBI Accession #    P68366.1 [Other Products]
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 UniProt Primary Accession #    P68366 [Other Products]
 UniProt Secondary Accession #    P05215; A8MUB1; B3KNQ6 [Other Products]
 UniProt Related Accession #    P68366 [Other Products]
 Molecular Weight    48,329 Da
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 NCBI Official Full Name    Tubulin alpha-4A chain
 NCBI Official Synonym Full Names    tubulin alpha 4a
 NCBI Official Symbol    TUBA4A [Similar Products]
 NCBI Official Synonym Symbols   
ALS22; TUBA1; H2-ALPHA
[Similar Products]
 NCBI Protein Information    tubulin alpha-4A chain
 UniProt Protein Name    Tubulin alpha-4A chain
 UniProt Synonym Protein Names   
Alpha-tubulin 1; Testis-specific alpha-tubulin; Tubulin H2-alpha; Tubulin alpha-1 chain
 Protein Family    Tubulin
 UniProt Gene Name    TUBA4A [Similar Products]
 UniProt Synonym Gene Names    TUBA1 [Similar Products]
 UniProt Entry Name    TBA4A_HUMAN
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 NCBI Summary for TUBA4A    Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
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 UniProt Comments for TUBA4A    TUBA4A: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. Belongs to the tubulin family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: cytosol; extracellular region; microtubule

Molecular Function: protein binding

Biological Process: G2/M transition of mitotic cell cycle; platelet degranulation

Disease: Amyotrophic Lateral Sclerosis 22 With Or Without Frontotemporal Dementia
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 Research Articles on TUBA4A    1. This study mutational screening revealed the presence of four novel heterozygous variants of TUBA4A mutation in four sporadic amyotrophic lateral sclerosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with TUBA4A blocking peptideDiseases associated with TUBA4A blocking peptide
 Products by Pathway  Pathway Diagram
 AURKA Activation By TPX2 Pathway antibodies  AURKA Activation By TPX2 Pathway Diagram
 Anchoring Of The Basal Body To The Plasma Membrane Pathway antibodies  Anchoring Of The Basal Body To The Plasma Membrane Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 Chaperonin-mediated Protein Folding Pathway antibodies  Chaperonin-mediated Protein Folding Pathway Diagram
 Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway antibodies  Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with TUBA4A and Nervous System Diseases
 Brain Diseases Antibodies  >2 publications with TUBA4A and Brain Diseases
 Ataxia Antibodies  >1 publications with TUBA4A and Ataxia
 Memory Disorders Antibodies  >1 publications with TUBA4A and Memory Disorders
Organs/Tissues associated with TUBA4A blocking peptide
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with TUBA4A and Brain
 Nerve Antibodies  >1 publications with TUBA4A and Nerve
 Blood Antibodies  >1 publications with TUBA4A and Blood
 Testis Antibodies  >1 publications with TUBA4A and Testis
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