Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Blocking Peptide rightarrow XPO5  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • myeloid differential protein-2 (MD-2) ELISA Kit
 • GADD45A cDNA Clone
 • Regenerating Islet Derived Protein 3 Alpha (REG3a) Antibody
 • CA3 Antibody
 • COX7A1 Antibody
 • Troponin I Antigen
 • CD11c Antibody
 • 14-3-3 protein zeta (ywhaz) Recombinant Protein
 • chemokine (C-X-C motif) ligand 10 (CXCL10) ELISA Kit
 • Hereditary hemochromatosis protein (HFE) Recombinant Protein
 • IgG Antibody
 • WWP1 cDNA Clone
 • ATP-binding cassette, sub-family B (MDR-TAP), member 7 (ABC... Antibody
 • GDF8 - Myostatin Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

XPO5 blocking peptide

Scan QR to view Datasheet Catalog #    MBS9221393 XPO5 blocking peptide
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

XPO5, Blocking Peptide

 Also Known As   

XPO5 Antibody (C-term) Blocking Peptide

 Product Synonym Names    Exportin-5; Exp5; Ran-binding protein 21; XPO5; KIAA1291; RANBP21
 Product Gene Name   

XPO5 blocking peptide

[Similar Products]
 Product Synonym Gene Name    KIAA1291; RANBP21 [Similar Products]
 Antibody/Peptide Pairs    XPO5 peptide (MBS9221393) is used for blocking the activity of XPO5 antibody (MBS9213268)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    607845
 3D Structure    ModBase 3D Structure for Q9HAV4
Section Bar
Section Bar
 Form/Format    Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Section Bar
 Cellular Location    Nucleus. Cytoplasm. Note: Shuttles between the nucleus and the cytoplasm
 Tissue Location    Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas
Section Bar
 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of XPO5 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for XPO5 blocking peptide

   Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner.
NCBI/Uniprot data below describe general gene information for XPO5. It may not necessarily be applicable to this product.
 NCBI GI #    74734245
 NCBI GeneID    57510
 NCBI Accession #    Q9HAV4.1 [Other Products]
Section Bar
 UniProt Primary Accession #    Q9HAV4 [Other Products]
 UniProt Secondary Accession #    Q5JTE6; Q96G48; Q96HN3; Q9BWM6; Q9BZV5; Q9H9M4; Q9NT89; Q9NW39; Q9ULC9 [Other Products]
 UniProt Related Accession #    Q9HAV4 [Other Products]
 Molecular Weight    136,311 Da
Table BarTOPTable Bar
 NCBI Official Full Name    Exportin-5
 NCBI Official Synonym Full Names    exportin 5
 NCBI Official Symbol    XPO5 [Similar Products]
 NCBI Official Synonym Symbols   
exp5
[Similar Products]
 NCBI Protein Information    exportin-5
 UniProt Protein Name    Exportin-5
 UniProt Synonym Protein Names   
Ran-binding protein 21
 Protein Family    Exportin
 UniProt Gene Name    XPO5 [Similar Products]
 UniProt Synonym Gene Names    KIAA1291; RANBP21; Exp5 [Similar Products]
 UniProt Entry Name    XPO5_HUMAN
Section Bar
 NCBI Summary for XPO5    This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011]
Section Bar
 UniProt Comments for XPO5    Exportin-5: mediates the nuclear export of proteins bearing double-stranded RNA binding domains and double-stranded RNA. Overexpression enhances RNA interference mediated by shRNAs and miRNAs. In the nucleus it binds cooperatively to its cargo and to Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. Exp5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear export; Karyopherin; Nuclear import; RNA-binding

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: mRNA binding; protein binding; Ran GTPase binding; RNA binding

Biological Process: pre-microRNA export from nucleus; protein export from nucleus; RNA-mediated gene silencing
Table BarTOPTable Bar
 Research Articles on XPO5    1. Variations in XPO5 rs11077 of Korean patients are significantly associated with their risk of colorectal cancer.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with XPO5 blocking peptidePathways associated with XPO5 blocking peptide
 Reference Product  PubMed Publications
 DROSHA blocking peptide  >37 publications with XPO5 and DROSHA
 RAN blocking peptide  >35 publications with XPO5 and RAN
 DICER1 blocking peptide  >23 publications with XPO5 and DICER1
 DGCR8 blocking peptide  >19 publications with XPO5 and DGCR8
 TARBP2 blocking peptide  >12 publications with XPO5 and TARBP2
 ILF3 blocking peptide  >5 publications with XPO5 and ILF3
 NUP153 blocking peptide  >1 publications with XPO5 and NUP153
 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Gene Silencing By RNA Pathway antibodies  Gene Silencing By RNA Pathway Diagram
 MicroRNA (miRNA) Biogenesis Pathway antibodies  MicroRNA (miRNA) Biogenesis Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
Diseases associated with XPO5 blocking peptideOrgans/Tissues associated with XPO5 blocking peptide
 Disease Name  Pubmed Publications
 Microsatellite Instability Antibodies  >6 publications with XPO5 and Microsatellite Instability
 Congenital, Hereditary, and Neonatal Diseases and Abnormalities Antibodies  >4 publications with XPO5 and Congenital, Hereditary, and Neonatal Diseases and Abnormalities
 Kidney Diseases Antibodies  >3 publications with XPO5 and Kidney Diseases
 Carcinoma, Squamous Cell Antibodies  >3 publications with XPO5 and Carcinoma, Squamous Cell
 Ovarian Diseases Antibodies  >2 publications with XPO5 and Ovarian Diseases
 Cell Transformation, Neoplastic Antibodies  >2 publications with XPO5 and Cell Transformation, Neoplastic
 Ovarian Neoplasms Antibodies  >2 publications with XPO5 and Ovarian Neoplasms
 Neoplasms, Experimental Antibodies  >2 publications with XPO5 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >1 publications with XPO5 and Disease Models, Animal
 Abnormalities, Multiple Antibodies  >1 publications with XPO5 and Abnormalities, Multiple
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >7 publications with XPO5 and Lung
 Liver Antibodies  >6 publications with XPO5 and Liver
 Blood Antibodies  >5 publications with XPO5 and Blood
 Brain Antibodies  >4 publications with XPO5 and Brain
 Kidney Antibodies  >3 publications with XPO5 and Kidney
 Embryonic Tissue Antibodies  >3 publications with XPO5 and Embryonic Tissue
 Placenta Antibodies  >2 publications with XPO5 and Placenta
 Thyroid Antibodies  >2 publications with XPO5 and Thyroid
 Muscle Antibodies  >2 publications with XPO5 and Muscle
 Stomach Antibodies  >2 publications with XPO5 and Stomach
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions