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ZEB1 blocking peptide

Scan QR to view Datasheet Catalog #    MBS151812 ZEB1 blocking peptide
Unit / Price
0.05 mg  /  $140 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ZEB1, Blocking Peptide

 Also Known As   

ZEB1 Peptide

 Product Synonym Names    BZP; TCF8; AREB6; FECD6; NIL2A; PPCD3; ZFHEP; ZFHX1A; DELTAEF1; Zinc finger E-box-binding homeobox 1; NIL-2-A zinc finger protein; TCF-8; zinc finger E-box binding homeobox 1
 Product Gene Name   

ZEB1 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    ZEB1 peptide (MBS151812) is used for blocking the activity of ZEB1 antibody (MBS151570)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Western Blot Protocol    Western Blot Peptide Blocking Protocol
 OMIM    phenotype 613270
 3D Structure    ModBase 3D Structure for P37275
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 Form/Format    Liquid
 Concentration    200 ug/mL (lot specific)
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 Species    Human
 Buffer    PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
 Location    15 amino acids near the center of human ZEB1.
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 Preparation and Storage    Store ZEB1 peptide at -20 degree C, stable for one year.
 Other Notes    Small volumes of ZEB1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for ZEB1 blocking peptide   

Blocking (BL)

 Application Notes for ZEB1 blocking peptide    ZEB1 peptide is used for blocking the activity of ZEB1 antibody.
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NCBI/Uniprot data below describe general gene information for ZEB1. It may not necessarily be applicable to this product.
 NCBI GI #    55957123
 NCBI GeneID    6935
 NCBI Accession #    CAI12550 [Other Products]
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 UniProt Primary Accession #    P37275 [Other Products]
 UniProt Secondary Accession #    Q12924; Q13800; Q2KJ05; Q5T968; Q5VZ84; Q8NB68; B4DJV0; B4DUW9; E9PCM7; F5H4I8 [Other Products]
 UniProt Related Accession #    P37275 [Other Products]
 Molecular Weight    122,084 Da
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 NCBI Official Synonym Full Names    zinc finger E-box binding homeobox 1
 NCBI Official Symbol    ZEB1 [Similar Products]
 NCBI Official Synonym Symbols   
BZP; TCF8; AREB6; FECD6; NIL2A; PPCD3; ZFHEP; ZFHX1A; DELTAEF1
[Similar Products]
 NCBI Protein Information    zinc finger E-box-binding homeobox 1
 UniProt Protein Name    Zinc finger E-box-binding homeobox 1
 UniProt Synonym Protein Names   
NIL-2-A zinc finger protein; Negative regulator of IL2; Transcription factor 8; TCF-8
 Protein Family    Zinc finger E-box-binding homeobox
 UniProt Gene Name    ZEB1 [Similar Products]
 UniProt Synonym Gene Names    AREB6; TCF8; TCF-8 [Similar Products]
 UniProt Entry Name    ZEB1_HUMAN
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 NCBI Summary for ZEB1    This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]
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 UniProt Comments for ZEB1    TCF8: Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Interacts (via N-terminus) with SMARCA4/BRG1. Colocalizes with SMARCA4/BRG1 in E-cadherin- negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas. Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas. Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

Protein type: DNA-binding; Transcription, coactivator/corepressor; C2H2-type zinc finger protein; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10p11.2

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus

Molecular Function: protein binding; zinc ion binding; transcription coactivator activity; double-stranded DNA binding; chromatin binding; transcription corepressor activity; transcription factor binding; transcription factor activity

Biological Process: response to nutrient levels; transcription, DNA-dependent; regulation of T cell differentiation in the thymus; semicircular canal morphogenesis; negative regulation of epithelial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; pattern specification process; embryonic skeletal morphogenesis; regulation of mesenchymal cell proliferation; regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; cell proliferation; regulation of transforming growth factor beta receptor signaling pathway; cartilage development; forebrain development; regulation of smooth muscle cell differentiation; immune response; positive regulation of transcription from RNA polymerase II promoter; embryonic camera-type eye morphogenesis; response to activity; positive regulation of neuron differentiation; negative regulation of transcription, DNA-dependent

Disease: Corneal Dystrophy, Posterior Polymorphous, 3; Corneal Dystrophy, Fuchs Endothelial, 6
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 Research Articles on ZEB1    1. Our results correlated ZEB1 with aggressive potentials of breast carcinoma and revealed a possibility for ZEB1 as a prognostic marker in breast carcinoma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ZEB1 blocking peptidePathways associated with ZEB1 blocking peptide
 Reference Product  PubMed Publications
 CDH1 blocking peptide  >53 publications with ZEB1 and CDH1
 VIM blocking peptide  >13 publications with ZEB1 and VIM
 STAT3 blocking peptide  >8 publications with ZEB1 and STAT3
 CDH2 blocking peptide  >8 publications with ZEB1 and CDH2
 ETS1 blocking peptide  >4 publications with ZEB1 and ETS1
 CTBP1 blocking peptide  >3 publications with ZEB1 and CTBP1
 CTBP2 blocking peptide  >3 publications with ZEB1 and CTBP2
 PKP3 blocking peptide  >1 publications with ZEB1 and PKP3
 PARP1 blocking peptide  >1 publications with ZEB1 and PARP1
 Products by Pathway  Pathway Diagram
 Hypertrophy Model Pathway antibodies  Hypertrophy Model Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
Diseases associated with ZEB1 blocking peptideOrgans/Tissues associated with ZEB1 blocking peptide
 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >142 publications with ZEB1 and Neoplasm Metastasis
 Neoplasm Invasiveness Antibodies  >122 publications with ZEB1 and Neoplasm Invasiveness
 Breast Neoplasms Antibodies  >107 publications with ZEB1 and Breast Neoplasms
 Skin Diseases Antibodies  >96 publications with ZEB1 and Skin Diseases
 Adenocarcinoma Antibodies  >86 publications with ZEB1 and Adenocarcinoma
 Disease Progression Antibodies  >76 publications with ZEB1 and Disease Progression
 Lung Neoplasms Antibodies  >61 publications with ZEB1 and Lung Neoplasms
 Lung Diseases Antibodies  >51 publications with ZEB1 and Lung Diseases
 Cell Transformation, Neoplastic Antibodies  >40 publications with ZEB1 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >33 publications with ZEB1 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >100 publications with ZEB1 and Lung
 Embryonic Tissue Antibodies  >50 publications with ZEB1 and Embryonic Tissue
 Blood Antibodies  >46 publications with ZEB1 and Blood
 Prostate Antibodies  >44 publications with ZEB1 and Prostate
 Liver Antibodies  >42 publications with ZEB1 and Liver
 Muscle Antibodies  >38 publications with ZEB1 and Muscle
 Eye Antibodies  >37 publications with ZEB1 and Eye
 Kidney Antibodies  >34 publications with ZEB1 and Kidney
 Lymph Node Antibodies  >33 publications with ZEB1 and Lymph Node
 Vascular Antibodies  >29 publications with ZEB1 and Vascular
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