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ZEB2 blocking peptide

Scan QR to view Datasheet Catalog #    MBS152039 ZEB2 blocking peptide
Unit / Price
0.05 mg  /  $135 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ZEB2, Blocking Peptide

 Also Known As   

ZEB2 Peptide

 Product Synonym Names    SIP1; SIP-1; ZFHX1B; HSPC082; SMADIP1; KIAA0569; SIP1; ZFX1B; HRIHFB2411; Zinc finger E-box-binding homeobox 2; Smad-interacting protein 1; zinc finger E-box binding homeobox 2
 Product Gene Name   

ZEB2 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    ZEB2 peptide (MBS152039) is used for blocking the activity of ZEB2 antibody (MBS150898)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Western Blot Protocol    Western Blot Peptide Blocking Protocol
 OMIM    phenotype 605802
 3D Structure    ModBase 3D Structure for O60315
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 Form/Format    Liquid
 Concentration    200 ug/mL (lot specific)
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 Species    Human
 Buffer    PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
 Location    18 amino acids near the carboxy terminus of human ZEB2.
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 Preparation and Storage    Store ZEB2 peptide at -20 degree C, stable for one year.
 Other Notes    Small volumes of ZEB2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for ZEB2 blocking peptide   

Blocking (BL)

 Application Notes for ZEB2 blocking peptide    ZEB2 peptide is used for blocking the activity of ZEB2 antibody.
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NCBI/Uniprot data below describe general gene information for ZEB2. It may not necessarily be applicable to this product.
 NCBI GI #    117558786
 NCBI GeneID    9839
 NCBI Accession #    AAI27103 [Other Products]
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 UniProt Primary Accession #    O60315 [Other Products]
 UniProt Secondary Accession #    Q9UED1; A0JP09; B7Z2P2; F5H814 [Other Products]
 UniProt Related Accession #    O60315 [Other Products]
 Molecular Weight    133,806 Da
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 NCBI Official Full Name    Zinc finger E-box binding homeobox 2
 NCBI Official Synonym Full Names    zinc finger E-box binding homeobox 2
 NCBI Official Symbol    ZEB2 [Similar Products]
 NCBI Official Synonym Symbols   
SIP1; SIP-1; ZFHX1B; HSPC082; SMADIP1
[Similar Products]
 NCBI Protein Information    zinc finger E-box-binding homeobox 2; zinc finger homeobox 1b; SMAD interacting protein 1; Smad-interacting protein 1
 UniProt Protein Name    Zinc finger E-box-binding homeobox 2
 UniProt Synonym Protein Names   
Smad-interacting protein 1; SMADIP1; Zinc finger homeobox protein 1b
 Protein Family    Zinc finger E-box-binding homeobox
 UniProt Gene Name    ZEB2 [Similar Products]
 UniProt Synonym Gene Names    KIAA0569; SIP1; ZFHX1B; ZFX1B; SMADIP1 [Similar Products]
 UniProt Entry Name    ZEB2_HUMAN
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 NCBI Summary for ZEB2    The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]
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 UniProt Comments for ZEB2    ZEB2: Transcriptional inhibitor that binds to DNA sequence 5'- CACCT-3' in different promoters. Represses transcription of E- cadherin. Defects in ZEB2 are the cause of Mowat-Wilson syndrome (MWIS); also known as Hirschsprung disease-mental retardation syndrome. A complex developmental disorder characterized by mental retardation, delayed motor development, epilepsy, microcephaly and a wide spectrum of clinically heterogeneous features suggestive of neurocristopathies at the cephalic, cardiac, and vagal levels. Some patients manifest Hirschsprung disease. Affected patients show an easily recognizable facial appearance with deep set eyes and hypertelorism, medially divergent, broad eyebrows, prominent columella, pointed chin and uplifted, notched ear lobes. Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

Protein type: C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor; DNA-binding

Chromosomal Location of Human Ortholog: 2q22.3

Cellular Component: nucleus

Molecular Function: DNA binding; phosphatase regulator activity; metal ion binding

Biological Process: nervous system development; positive regulation of JNK activity; somitogenesis; transcription, DNA-dependent; cell proliferation in forebrain; pigmentation during development; hippocampus development; positive regulation of melanin biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of melanocyte differentiation; neural tube closure; positive regulation of transcription from RNA polymerase II promoter; positive regulation of Wnt receptor signaling pathway; neural crest cell migration

Disease: Mowat-wilson Syndrome
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 Research Articles on ZEB2    1. High ZEB2 expression is associated with epithelial-to-mesenchymal transition in prostate cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ZEB2 blocking peptidePathways associated with ZEB2 blocking peptide
 Reference Product  PubMed Publications
 CDH1 blocking peptide  >24 publications with ZEB2 and CDH1
 SMAD2 blocking peptide  >6 publications with ZEB2 and SMAD2
 SMAD3 blocking peptide  >5 publications with ZEB2 and SMAD3
 MEOX2 blocking peptide  >3 publications with ZEB2 and MEOX2
 CBX4 blocking peptide  >1 publications with ZEB2 and CBX4
 CTBP2 blocking peptide  >1 publications with ZEB2 and CTBP2
 SMAD5 blocking peptide  >1 publications with ZEB2 and SMAD5
 Products by Pathway  Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 TGF Beta Signaling Pathway antibodies  TGF Beta Signaling Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
Diseases associated with ZEB2 blocking peptideOrgans/Tissues associated with ZEB2 blocking peptide
 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >64 publications with ZEB2 and Neoplasm Metastasis
 Mowat-Wilson syndrome Antibodies  >63 publications with ZEB2 and Mowat-Wilson syndrome
 Neoplasm Invasiveness Antibodies  >60 publications with ZEB2 and Neoplasm Invasiveness
 Disease Progression Antibodies  >42 publications with ZEB2 and Disease Progression
 Breast Neoplasms Antibodies  >42 publications with ZEB2 and Breast Neoplasms
 Heart Defects, Congenital Antibodies  >22 publications with ZEB2 and Heart Defects, Congenital
 Cell Transformation, Neoplastic Antibodies  >22 publications with ZEB2 and Cell Transformation, Neoplastic
 Lung Diseases Antibodies  >20 publications with ZEB2 and Lung Diseases
 Kidney Diseases Antibodies  >20 publications with ZEB2 and Kidney Diseases
 Liver Neoplasms Antibodies  >19 publications with ZEB2 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >39 publications with ZEB2 and Lung
 Kidney Antibodies  >35 publications with ZEB2 and Kidney
 Embryonic Tissue Antibodies  >33 publications with ZEB2 and Embryonic Tissue
 Heart Antibodies  >32 publications with ZEB2 and Heart
 Liver Antibodies  >30 publications with ZEB2 and Liver
 Brain Antibodies  >26 publications with ZEB2 and Brain
 Nerve Antibodies  >22 publications with ZEB2 and Nerve
 Blood Antibodies  >21 publications with ZEB2 and Blood
 Eye Antibodies  >18 publications with ZEB2 and Eye
 Muscle Antibodies  >17 publications with ZEB2 and Muscle
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