NP_001123644.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37,507 Da
NCBI Official Full Name
transcriptional activator Myb isoform 3
NCBI Official Synonym Full Names
MYB proto-oncogene, transcription factor
NCBI Protein Information
transcriptional activator Myb
UniProt Protein Name
Transcriptional activator Myb
UniProt Synonym Protein Names
Proto-oncogene c-Myb
UniProt Entry Name
MYB_HUMAN
NCBI Summary for MYB
This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
UniProt Comments for MYB
Myb: Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 6q22-q23
Cellular Component: nucleus
Molecular Function: protein binding
Biological Process: chromatin remodeling; mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of histone H3-K4 methylation; positive regulation of histone H3-K9 methylation; positive regulation of T-helper cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent
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Products associated with MYB blocking peptide
Pathways associated with MYB blocking peptide
Diseases associated with MYB blocking peptide
Organs/Tissues associated with MYB blocking peptide
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