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TP53 blocking peptide :: p53 Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS8243686 TP53 blocking peptide
Unit / Price
1 mg  /  $195 +1 FREE 8GB USB
5 mg  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

p53 (TP53), Blocking Peptide

 Also Known As   

p53 (pS9) Blocking Peptide

 Product Synonym Names    P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53
 Product Gene Name   

TP53 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    p53 peptide (MBS8243686) is used for blocking the activity of p53 antibody (MBS8242642)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    133239
 3D Structure    ModBase 3D Structure for P04637
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 Host    Synthetic
 Species Reactivity    Human, Monkey
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 Purity/Purification    >85%
 Form/Format    Lyophilized Powder
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 Quality Control    The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Other Notes    Small volumes of TP53 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for TP53 blocking peptide

   The peptide is used to block Anti-p53 reactivity.
 Applications Tested/Suitable for TP53 blocking peptide   

Blocking (BL)

 Application Notes for TP53 blocking peptide    Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
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NCBI/Uniprot data below describe general gene information for TP53. It may not necessarily be applicable to this product.
 NCBI GI #    269849759
 NCBI GeneID    7157
 NCBI Accession #    P04637.4 [Other Products]
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 UniProt Primary Accession #    P04637 [Other Products]
 UniProt Secondary Accession #    Q15086; Q15087; Q15088; Q16535; Q16807; Q16808; Q16809; Q16810; Q16811; Q16848; Q2XN98 [Other Products]
 UniProt Related Accession #    P04637 [Other Products]
 Molecular Weight    24,401 Da
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 NCBI Official Full Name    Cellular tumor antigen p53
 NCBI Official Synonym Full Names    tumor protein p53
 NCBI Official Symbol    TP53 [Similar Products]
 NCBI Official Synonym Symbols   
P53; BCC7; LFS1; TRP53
[Similar Products]
 NCBI Protein Information    cellular tumor antigen p53
 UniProt Protein Name    Cellular tumor antigen p53
 UniProt Synonym Protein Names   
Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53
 Protein Family    p53 and DNA damage-regulated protein
 UniProt Gene Name    TP53 [Similar Products]
 UniProt Synonym Gene Names    P53 [Similar Products]
 UniProt Entry Name    P53_HUMAN
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 NCBI Summary for TP53    This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]
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 UniProt Comments for TP53    p53: a transcription factor and major tumor suppressor that plays a major role in regulating cellular responses to DNA damage and other genomic aberrations. Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis. More than 50 percent of human tumors contain a mutation or deletion of the TP53 gene. p53 is modified post-translationally at multiple sites. DNA damage induces phosphorylation of p53 at S15, S20 and S37, reducing its interaction with the oncoprotein MDM2. MDM2 inhibits p53 accumulation by targeting it for ubiquitination and proteasomal degradation. Phosphorylated by many kinases including Chk2 and Chk1 at S20, enhancing its tetramerization, stability and activity. The phosphorylation by CAK at S392 is increased in human tumors and has been reported to influence the growth suppressor function, DNA binding and transcriptional activation of p53. Phosphorylation of p53 at S46 regulates the ability of p53 to induce apoptosis. The acetylation of p53 appears to play a positive role in the accumulation of p53 during the stress response. Following DNA damage, p53 becomes acetylated at K382, enhancing its binding to DNA. Deacetylation of p53 can occur through interaction with SIRT1, a deacetylase that may be involved in cellular aging and the DNA damage response. p53 regulates the transcription of a set of genes encoding endosomal proteins that regulate endosomal functions. These include STEAP3 and CHMP4C, which enhance exosome production, and CAV1 and CHMP4C, which produce a more rapid endosomal clearance of the EGFR from the plasma membrane. DNA damage regulates a p53-mediated secretory pathway, increasing the secretion of some proteins such as Hsp90, SERPINE1, SERPINB5, NKEF-A, and CyPA, and inhibiting the secretion of others including CTSL and IGFBP-2. Two alternatively spliced human isoforms have been reported. Isoform 2 is expressed in quiescent lymphocytes. Seems to be non-functional. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Protein type: Transcription factor; Motility/polarity/chemotaxis; Activator; Tumor suppressor; DNA-binding; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; mitochondrial matrix; mitochondrion; nuclear body; nuclear chromatin; nuclear matrix; nucleolus; nucleoplasm; nucleus; PML body; protein complex; replication fork; transcription factor TFIID complex

Molecular Function: ATP binding; chaperone binding; chromatin binding; copper ion binding; damaged DNA binding; DNA binding; double-stranded DNA binding; enzyme binding; histone acetyltransferase binding; histone deacetylase regulator activity; identical protein binding; p53 binding; protease binding; protein binding; protein heterodimerization activity; protein kinase binding; protein N-terminus binding; protein phosphatase 2A binding; protein phosphatase binding; protein self-association; receptor tyrosine kinase binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding; ubiquitin protein ligase binding; zinc ion binding

Biological Process: apoptosis; B cell lineage commitment; base-excision repair; blood coagulation; cell aging; cell cycle arrest; cell differentiation; cell proliferation; cellular response to glucose starvation; cerebellum development; chromatin assembly; chromosome breakage; circadian behavior; determination of adult life span; DNA damage response, signal transduction by p53 class mediator; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA repair; DNA strand renaturation; double-strand break repair; embryonic organ development; entrainment of circadian clock by photoperiod; ER overload response; G1 DNA damage checkpoint; gastrulation; gene expression; in utero embryonic development; mitochondrial DNA repair; multicellular organism growth; multicellular organismal development; negative regulation of apoptosis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of fibroblast proliferation; negative regulation of helicase activity; negative regulation of neuroblast proliferation; negative regulation of proteolysis; negative regulation of telomerase activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway; neuron apoptosis; Notch signaling pathway; nucleotide-excision repair; positive regulation of apoptosis; positive regulation of histone deacetylation; positive regulation of neuron apoptosis; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein oligomerization; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; programmed cell death; protein complex assembly; protein import into nucleus, translocation; protein localization; protein tetramerization; Ras protein signal transduction; regulation of apoptosis; regulation of mitochondrial membrane permeability; regulation of tissue remodeling; regulation of transcription, DNA-dependent; release of cytochrome c from mitochondria; response to antibiotic; response to DNA damage stimulus; response to gamma radiation; response to salt stress; response to X-ray; rRNA transcription; somitogenesis; T cell differentiation in the thymus; T cell lineage commitment; T cell proliferation during immune response; transcription initiation from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; viral reproduction

Disease: Adrenocortical Carcinoma, Hereditary; Basal Cell Carcinoma, Susceptibility To, 7; Breast Cancer; Colorectal Cancer; Glioma Susceptibility 1; Hepatocellular Carcinoma; Li-fraumeni Syndrome 1; Nasopharyngeal Carcinoma; Osteogenic Sarcoma; Pancreatic Cancer; Papilloma Of Choroid Plexus
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 Research Articles on TP53    1. Parkinson disease induction increased the expression of the apoptotic mediators p53 and active caspase-3 in gastrocnemius muscle.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TP53 blocking peptidePathways associated with TP53 blocking peptide
 Reference Product  PubMed Publications
 MDM2 blocking peptide  >1048 publications with TP53 and MDM2
 CDKN1A blocking peptide  >794 publications with TP53 and CDKN1A
 CDKN2A blocking peptide  >782 publications with TP53 and CDKN2A
 ATM blocking peptide  >532 publications with TP53 and ATM
 BRCA1 blocking peptide  >524 publications with TP53 and BRCA1
 SIRT1 blocking peptide  >82 publications with TP53 and SIRT1
 EP300 blocking peptide  >40 publications with TP53 and EP300
 CREBBP blocking peptide  >29 publications with TP53 and CREBBP
 MAPK8 blocking peptide  >8 publications with TP53 and MAPK8
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Activation Of NOXA And Translocation To Mitochondria Pathway antibodies  Activation Of NOXA And Translocation To Mitochondria Pathway Diagram
 Activation Of PUMA And Translocation To Mitochondria Pathway antibodies  Activation Of PUMA And Translocation To Mitochondria Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
Diseases associated with TP53 blocking peptideOrgans/Tissues associated with TP53 blocking peptide
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >3395 publications with TP53 and Carcinoma
 Breast Neoplasms Antibodies  >1288 publications with TP53 and Breast Neoplasms
 Colorectal Neoplasms Antibodies  >841 publications with TP53 and Colorectal Neoplasms
 Carcinoma, Squamous Cell Antibodies  >789 publications with TP53 and Carcinoma, Squamous Cell
 Glioma Antibodies  >665 publications with TP53 and Glioma
 Central Nervous System Neoplasms Antibodies  >582 publications with TP53 and Central Nervous System Neoplasms
 Neoplasm Metastasis Antibodies  >495 publications with TP53 and Neoplasm Metastasis
 Cell Transformation, Neoplastic Antibodies  >465 publications with TP53 and Cell Transformation, Neoplastic
 Sarcoma Antibodies  >432 publications with TP53 and Sarcoma
 Liver Neoplasms Antibodies  >421 publications with TP53 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1107 publications with TP53 and Blood
 Lung Antibodies  >979 publications with TP53 and Lung
 Brain Antibodies  >725 publications with TP53 and Brain
 Liver Antibodies  >537 publications with TP53 and Liver
 Bone Antibodies  >416 publications with TP53 and Bone
 Skin Antibodies  >373 publications with TP53 and Skin
 Lymph Node Antibodies  >367 publications with TP53 and Lymph Node
 Lymph Antibodies  >358 publications with TP53 and Lymph
 Bladder Antibodies  >323 publications with TP53 and Bladder
 Prostate Antibodies  >277 publications with TP53 and Prostate
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