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WNK1 blocking peptide :: p65 Blocking Peptide

Scan QR to view Datasheet Catalog #    MBS8221722 WNK1 blocking peptide
Unit / Price
1 mg  /  $195 +1 FREE 8GB USB
5 mg  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

p65 (WNK1), Blocking Peptide

 Also Known As   

p65 (pT60) Blocking Peptide

 Product Synonym Names    HSN2; KDP; KIAA0344; PRKWNK1; Serine/threonine-protein kinase WNK1; Erythrocyte 65 kDa protein; p65; Kinase deficient protein; Protein kinase lysine-deficient 1; Protein kinase with no lysine 1; hWNK1
 Product Gene Name   

WNK1 blocking peptide

[Similar Products]
 Antibody/Peptide Pairs    p65 peptide (MBS8221722) is used for blocking the activity of p65 antibody (MBS8224397)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    201300
 3D Structure    ModBase 3D Structure for Q9H4A3
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 Host    Synthetic
 Species Reactivity    Human, Mouse, Rat, Porcine
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 Purity/Purification    >85%
 Form/Format    Lyophilized powder
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 Quality Control    The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
 Directions for Use    Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Other Notes    Small volumes of WNK1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for WNK1 blocking peptide

   The peptide is used to block Anti-p65 (pT60) Antibody reactivity.
 Applications Tested/Suitable for WNK1 blocking peptide   

Blocking (BL)

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NCBI/Uniprot data below describe general gene information for WNK1. It may not necessarily be applicable to this product.
 NCBI GI #    296939600
 NCBI GeneID    65125
 NCBI Accession #    NP_001171914.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001184985.1 [Other Products]
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 UniProt Primary Accession #    Q9H4A3 [Other Products]
 UniProt Secondary Accession #    O15052; P54963; Q4VBX9; Q6IFS5; Q86WL5; Q8N673; A1L4B0; C5HTZ5; C5HTZ6; C5HTZ7; H6WZW3 [Other Products]
 UniProt Related Accession #    Q9H4A3 [Other Products]
 Molecular Weight    299,725 Da
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 NCBI Official Full Name    serine/threonine-protein kinase WNK1 isoform 4
 NCBI Official Synonym Full Names    WNK lysine deficient protein kinase 1
 NCBI Official Symbol    WNK1 [Similar Products]
 NCBI Official Synonym Symbols   
KDP; PSK; p65; HSN2; HSAN2; PRKWNK1; PPP1R167
[Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase WNK1
 UniProt Protein Name    Serine/threonine-protein kinase WNK1
 UniProt Synonym Protein Names   
Erythrocyte 65 kDa protein; p65; Kinase deficient protein; Protein kinase lysine-deficient 1; Protein kinase with no lysine 1; hWNK1
 Protein Family    Probable serine/threonine-protein kinase
 UniProt Gene Name    WNK1 [Similar Products]
 UniProt Synonym Gene Names    HSN2; KDP; KIAA0344; PRKWNK1; p65; hWNK1 [Similar Products]
 UniProt Entry Name    WNK1_HUMAN
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 NCBI Summary for WNK1    This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]
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 UniProt Comments for WNK1    WNK1: a serine-threonine protein kinase that controls sodium and chloride ion transport. May regulate the activity of the thiazide-sensitive Na-Cl cotransporter SLC12A3 by phosphorylation. May also play a role in actin cytoskeletal reorganization.

Protein type: Protein kinase, Other; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Other group; Wnk family

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: cytoplasm

Molecular Function: protein serine/threonine kinase activity; protein binding; chloride channel inhibitor activity; protein kinase inhibitor activity; ATP binding; phosphatase binding

Biological Process: regulation of cellular process; peptidyl-threonine phosphorylation; negative regulation of protein kinase activity; neuron development; ion transport; protein amino acid phosphorylation

Disease: Pseudohypoaldosteronism, Type Iic; Neuropathy, Hereditary Sensory And Autonomic, Type Iia
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 Research Articles on WNK1    1. enhances BK channel function by reducing ERK1/2 signaling-mediated lysosomal degradation of the channel
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with WNK1 blocking peptidePathways associated with WNK1 blocking peptide
 Reference Product  PubMed Publications
 KLHL3 blocking peptide  >24 publications with WNK1 and KLHL3
 SLC12A3 blocking peptide  >20 publications with WNK1 and SLC12A3
 KCNJ1 blocking peptide  >17 publications with WNK1 and KCNJ1
 SCNN1A blocking peptide  >3 publications with WNK1 and SCNN1A
 SCNN1G blocking peptide  >3 publications with WNK1 and SCNN1G
 SCNN1B blocking peptide  >2 publications with WNK1 and SCNN1B
 SYT2 blocking peptide  >1 publications with WNK1 and SYT2
 Products by Pathway  Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Stimuli-sensing Channels Pathway antibodies  Stimuli-sensing Channels Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
Diseases associated with WNK1 blocking peptideOrgans/Tissues associated with WNK1 blocking peptide
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >171 publications with WNK1 and Hypertension
 Pseudohypoaldosteronism Antibodies  >94 publications with WNK1 and Pseudohypoaldosteronism
 Kidney Diseases Antibodies  >72 publications with WNK1 and Kidney Diseases
 Congenital Abnormalities Antibodies  >22 publications with WNK1 and Congenital Abnormalities
 Peripheral Nervous System Diseases Antibodies  >19 publications with WNK1 and Peripheral Nervous System Diseases
 Disease Models, Animal Antibodies  >19 publications with WNK1 and Disease Models, Animal
 Fibrosis Antibodies  >8 publications with WNK1 and Fibrosis
 Brain Diseases Antibodies  >5 publications with WNK1 and Brain Diseases
 Hyperplasia Antibodies  >2 publications with WNK1 and Hyperplasia
 Inflammation Antibodies  >2 publications with WNK1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >136 publications with WNK1 and Kidney
 Blood Antibodies  >102 publications with WNK1 and Blood
 Brain Antibodies  >28 publications with WNK1 and Brain
 Nerve Antibodies  >26 publications with WNK1 and Nerve
 Heart Antibodies  >18 publications with WNK1 and Heart
 Vascular Antibodies  >16 publications with WNK1 and Vascular
 Muscle Antibodies  >9 publications with WNK1 and Muscle
 Bone Antibodies  >6 publications with WNK1 and Bone
 Embryonic Tissue Antibodies  >5 publications with WNK1 and Embryonic Tissue
 Skin Antibodies  >5 publications with WNK1 and Skin
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