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ABCA 1 clia kit :: Rat ABCA1 (ATP Binding Cassette Transporter A1) CLIA Kit

Scan QR to view Datasheet Catalog #    MBS2532472
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $450 +1 FREE 8GB USB
96-Strip-Wells  /  $535 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,255 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,975 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABCA1 (ATP Binding Cassette Transporter A1) (ABCA 1), CLIA Kit

 Also Known As   

Rat ABCA1 (ATP Binding Cassette Transporter A1) CLIA Kit

 Product Gene Name   

ABCA 1 clia kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    205400
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 Species Reactivity    Rat
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 Specificity    This kit recognizes natural and recombinant ABCA 1. No significant cross-reactivity or interference between ABCA 1 and analogues was observed.
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 Assay Type    Sandwich
 Detection Range    31.25-2000pg/mL
 Sensitivity    Min: 18.75pg/mL; Max: 2000pg/mL
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our CLIA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ABCA 1 clia kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ABCA 1 clia kit

   Intended Uses: This CLIA kit applies to the in vitro quantitative determination of ABCA 1 concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This kit uses Sandwich-CLIA as the method. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to ABCA 1. Standards or samples are added to the appropriate micro CLIA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for ABCA 1 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain ABCA 1, biotinylated detection antibody and Avidin-HRP conjugate will appear fluorescence. The Relative light unit (RLU) value is measured spectrophotometrically by the Chemiluminescence immunoassay analyzer. The RLU value is positively associated with the concentration of ABCA 1. You can calculate the concentration of ABCA 1 in the samples by comparing the RLU value of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of ABCA 1 clia kit    ABCA 1 clia kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2532472. Click to request current manual
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NCBI/Uniprot data below describe general gene information for ABCA 1. It may not necessarily be applicable to this product.
 NCBI GI #    21536376
 NCBI GeneID    19
 NCBI Accession #    NP_005493.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005502.3 [Other Products]
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 UniProt Secondary Accession #    Q5VX33; Q96S56; Q96T85; Q9NQV4; Q9UN06; Q9UN07; Q9UN08; Q9UN09 [Other Products]
 UniProt Related Accession #    O95477 [Other Products]
 Molecular Weight    254,302 Da
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 NCBI Official Full Name    ATP-binding cassette sub-family A member 1
 NCBI Official Synonym Full Names    ATP-binding cassette, sub-family A (ABC1), member 1
 NCBI Official Symbol    ABCA1 [Similar Products]
 NCBI Official Synonym Symbols   
TGD; ABC1; CERP; ABC-1; HDLDT1
[Similar Products]
 NCBI Protein Information    ATP-binding cassette sub-family A member 1
 UniProt Protein Name    ATP-binding cassette sub-family A member 1
 UniProt Synonym Protein Names   
ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein
 UniProt Gene Name    ABCA1 [Similar Products]
 UniProt Synonym Gene Names    ABC1; CERP; ABC-1; ATP-binding cassette 1 [Similar Products]
 UniProt Entry Name    ABCA1_HUMAN
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 NCBI Summary for ABCA 1    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ABCA 1    ABCA1: an ATP-binding cassette (ABC) transporter that regulates cholesterol homeostasis and insulin secretion in beta-cells, and protects against cardiovascular disease. Inactivation of ABCA1 in beta-cells markedly impairs glucose tolerance and insulin secretion in mice. Rosiglitazone, an activator of the peroxisome proliferator-activated receptor-gamma, upregulates ABCA1 in beta-cells. ABCA1 expression in beta-cells is required for the beneficial effects of rosiglitazone on glucose tolerance. Mediates the transport of cholesterol and phospholipids from cells to HDL apolipoproteins, modulating HDL levels and atherogenesis. Induced by bacterial lipopolysaccharides (LPS) and repressed by ZNF202. Phosphorylation on Ser-2054 regulates phospholipid efflux. Unsaturated fatty acids destabilize ABCA1 by activating a PKC-delta pathway that phosphorylates ABCA1 serines. Defects in ABCA1 are a cause of high density lipoprotein deficiencies.

Protein type: Membrane protein, integral; Vesicle; Transporter, ABC family; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 9q31.1

Cellular Component: Golgi apparatus; perinuclear region of cytoplasm; endocytic vesicle; integral to plasma membrane; plasma membrane; phagocytic vesicle; external side of plasma membrane; lipid raft

Molecular Function: apolipoprotein A-I receptor activity; cholesterol binding; apolipoprotein binding; ATPase binding; apolipoprotein A-I binding; small GTPase binding; protein binding; phospholipid transporter activity; syntaxin binding; ATPase activity, coupled to transmembrane movement of substances; cholesterol transporter activity; anion transmembrane transporter activity; phospholipid binding; ATP binding; receptor binding

Biological Process: cholesterol metabolic process; regulation of Cdc42 protein signal transduction; lipoprotein metabolic process; cholesterol efflux; intracellular cholesterol transport; cellular lipid metabolic process; endosome transport; phospholipid translocation; G-protein coupled receptor protein signaling pathway; cholesterol homeostasis; reverse cholesterol transport; phospholipid efflux; platelet dense granule organization and biogenesis; lysosome organization and biogenesis; response to low density lipoprotein stimulus; positive regulation of cAMP biosynthetic process; protein amino acid lipidation; interleukin-1 beta secretion; phagocytosis, engulfment; transmembrane transport; phospholipid homeostasis; peptide secretion

Disease: Hypoalphalipoproteinemia, Primary; Tangier Disease; Hypercholesterolemia, Familial
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 Research Articles on ABCA 1    1. Hyperalphalipoproteinemics present a decrease in hsa-miR-33a and higher mRNA expression of ABCA1 and ABCG1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ABCA 1 clia kitPathways associated with ABCA 1 clia kit
 Reference Product  PubMed Publications
 APOE clia kit  >353 publications with ABCA 1 and APOE
 APOA1 clia kit  >143 publications with ABCA 1 and APOA1
 APOB clia kit  >89 publications with ABCA 1 and APOB
 PLTP clia kit  >32 publications with ABCA 1 and PLTP
 NR1H3 clia kit  >19 publications with ABCA 1 and NR1H3
 PPARA clia kit  >12 publications with ABCA 1 and PPARA
 NR1H2 clia kit  >10 publications with ABCA 1 and NR1H2
 SPTLC1 clia kit  >2 publications with ABCA 1 and SPTLC1
 CREBBP clia kit  >1 publications with ABCA 1 and CREBBP
 ARHGEF11 clia kit  >1 publications with ABCA 1 and ARHGEF11
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Folate Metabolism Pathway antibodies  Folate Metabolism Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
Organs/Tissues associated with ABCA 1 clia kit
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >918 publications with ABCA 1 and Liver
 Blood Antibodies  >815 publications with ABCA 1 and Blood
 Vascular Antibodies  >315 publications with ABCA 1 and Vascular
 Brain Antibodies  >189 publications with ABCA 1 and Brain
 Intestine Antibodies  >118 publications with ABCA 1 and Intestine
 Kidney Antibodies  >94 publications with ABCA 1 and Kidney
 Muscle Antibodies  >90 publications with ABCA 1 and Muscle
 Bone Antibodies  >85 publications with ABCA 1 and Bone
 Lung Antibodies  >80 publications with ABCA 1 and Lung
 Bone Marrow Antibodies  >76 publications with ABCA 1 and Bone Marrow
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